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B. Bosch, M.A. DeJesus, N.C. Poulton, W. Zhang, C.A. Engelhart, A. Zaveri, S. Lavalette, N. Ruecker, C. Trujillo, J.B. Wallach, S. Li, S. Ehrt, B.T. Chait, D. Schnappinger, J.M. Rock. “Genome-wide gene expression tuning reveals diverse vulnerabilities of M. tuberculosis”, Cell. 2021 Jul 16. [Epub ahead of print] [PMID: 34297925]

B. Malone, J. Chen, Q. Wang, E. Llewellyn, Y.J. Choi, P.D.B. Olinares, X. Cao, C. Hernandez, E.T. Eng, B.T. Chait, D.E. Shaw, R. Landick, S.A. Darst, E.A. Campbell. “Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex”, Proc Natl Acad Sci U S A. 2021 May 11. [PMID: 33883267]

F.D. Mast, P.C. Fridy, N.E. Ketaren, J. Wang, E.Y. Jacobs, J.P. Olivier, T. Sanyal, K.R. Molloy, F. Schmidt, M. Rutkowska, Y. Weisblum, L.M. Rich, E.R. Vanderwall, N. Dambrauskas, V. Vigdorovich, S. Keegan, J.B. Jiler, M.E. Stein, P.D.B. Olinares, T. Hatziioannou, D.N. Sather, J.S. Debley, D. Fenyö, A. Sali, P.D. Bieniasz, J.D. Aitchison, B.T. Chait, M.P. Rout. “Nanobody Repertoires for Exposing Vulnerabilities of SARS-CoV-2”, bioRxiv. 2021 Apr 10. [PMID: 33851164]

M. Wieczorek, S.C. Ti, L. Urnavicius, K.R. Molloy, A. Aher, B.T. Chait, T.M. Kapoor. "Biochemical reconstitutions reveal principles of human γ-TuRC assembly and function.", J Cell Biol. 2021 Mar 1;220(3):e202009146. [PMID: 33496729]

J. Merkenschlager, S. Finkin, V. Ramos, J. Kraft, M. Cipolla, C.R. Nowosad, H. Hartweger, W. Zhang, P.D.B. Olinares, A. Gazumyan, T.Y. Oliveira, B.T. Chait, M.C. Nussenzweig. “Dynamic regulation of TFHselection during the germinal centre reaction.”, Nature. 2021 Feb 3. doi: 10.1038/s41586-021-03187-x. [PMID: 33536617]

J.Y. Kang, E. Llewellyn, J. Chen, P.D.B. Olinares, J. Brewer, B.T. Chait, E.A. Campbell, S.A. Darst. “Structural basis for transcription complex disruption by the Mfd translocase.”, Elife. 2021 Jan 22;10:e62117. [PMID: 33480355]

J. Xu, X. Zhao, F. Mao, V. Basrur, B. Ueberheide, B.T. Chait, C.D. Allis, S.D. Taverna, S. Gao, W. Wang, Y. Liu. “A Polycomb repressive complex is required for RNAi-mediated heterochromatin formation and dynamic distribution of nuclear bodies.”, Nucleic Acids Res. 2021 Jan 8:gkaa1262. [PMID: 33412588]

M.A. Schureck, J.E. Darling, A. Merk, J. Shao, G. Daggupati, P. Srinivasan, P.D.B. Olinares, M.P. Rout, B.T. Chait, K. Wollenberg, S. Subramaniam, S.A. Desai. “Malaria parasites use a soluble RhopH complex for erythrocyte invasion and an integral form for nutrient uptake.”, Elife. 2021 Jan 4;10:e65282. [PMID: 33393463]


Z. Hakhverdyan, K.R. Molloy, S. Keegan, T. Herricks, D.M. Lepore, M. Munson, R.I. Subbotin, D. Fenyö, J.D. Aitchison, J. Fernandez-Martinez, B.T. Chait, M.P. Rout. Dissecting the structural dynamics of the nuclear pore complex.” Mol Cell. 2020 Dec 8:S1097-2765(20)30832-7. [PMID: 33333016]

P.D.B. Olinares, J.Y. Kang, E. Llewellyn, C. Chiu, J. Chen, B. Malone, R.M. Saecker, E.A. Campbell, S.A. Darst, B.T. Chait. “Native mass spectrometry-based screening for optimal sample preparation in single-particle cryo-EM.” Structure. 2020 Nov 17:S0969-2126(20)30413-5. [PMID: 33217329]

F.D. Mast, A.T. Navare, A.M. van der Sloot, J. Coulombe-Huntington, M.P. Rout, N.S. Baliga, A. Kaushansky, B.T. Chait, A. Aderem, C.M. Rice, A. Sali, M. Tyers, J.D. Aitchison. "Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality", J Cell Biol. 2020 Oct 5. 219 (10): e202006159. [PMID: 32785687]

Y. Dou, S. Kalmykova, M. Pashkova, M. Oghbaie, H. Jiang, K.R. Molloy, B.T. Chait, M.P. Rout, D. Fenyö, T.H. Jensen, I. Altukhov, J. LaCava. "Affinity proteomic dissection of the human nuclear cap-binding complex interactome", Nucleic Acids Res. 2020 Sep 22:gkaa743. [PMID: 32960270]

J. Chen, B. Malone, E. Llewellyn, M. Grasso, P.M.M. Shelton, P.D.B. Olinares, K. Maruthi, E. Eng, H. Vatandaslar, B.T. Chait, T. Kapoor, S.A. Darst, E.A. Campbell. “Structural basis for helicase-polymerase coupling in the SARS-CoV-2 replication-transcription complex”, Cell. 2020 Sep 17;182(6):1560-1573.e13. [PMID: 32783916]

K.J. Mickolajczyk, P.D.B. Olinares, Y. Niu, N. Chen, S.E. Warrington, Y. Sasaki, T. Walz, B.T. Chait, T.M. Kapoor. “Long-range intramolecular allostery and regulation in the dynein-like AAA protein Mdn1”, Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18459-18469. [PMID: 32694211]

J.M. Manning, L.R. Manning, A. Dumoulin, J.C. Padovan, B.T. Chait. “Embryonic and fetal human hemoglobins: structures, oxygen binding, and physiological roles”, Subcell Biochem. 2020;94:275-296. [PMID: 32189304]

J. Kagan, R.L. Moritz, R. Mazurchuk, J.H. Lee, P.V. Kharchenko, O. Rozenblatt-Rosen, E. Ruppin, F. Edfors, F. Ginty, Y. Goltsev, J.A. Wells, J. LaCava, J.L. Riesterer, R.N. Germain, T. Shi, M.S. Chee, B.A. Budnik, J.R. Yates 3rd, B.T. Chait, J.R. Moffitt, R.D. Smith, S. Srivastava . “National Cancer Institute Think-Tank Meeting Report on proteomic cartography and biomarkers at the single-cell level: interrogation of premalignant lesions”, J Proteome Res. 2020 May 1;19(5):1900-1912. [PMID: 32163288]

S.J. Ganesan, M.J. Feyder, I.E. Chemmama, F. Fang, M.P. Rout, B.T. Chait, Y. Shi, M. Munson, A. Sali. “Integrative structure and function of the yeast exocyst complex”, Protein Sci. 2020 Jun;29(6):1486-1501. [PMID: 32239688]

J. Chen, C. Chiu, S. Gopalkrishnan, A.Y. Chen, P.D.B. Olinares, R.M. Saecker, J.T. Winkelman, M.F. Maloney, B.T. Chait, W. Ross, R.L. Gourse, E.A. Campbell, S.A. Darst. “Stepwise Promoter Melting by Bacterial RNA Polymerase”, Mol Cell. 2020 Mar 2. [Epub ahead of print] [PMID: 32160514]

V. Kieuvongngam, P.D.B. Olinares, A. Palillo, M.L. Oldham, B.T. Chait, J. Chen. “Structural basis of substrate recognition by a polypeptide processing and secretion transporter”, Elife. 2020 Jan 14. [PMID: 31934861]

P.D.B. Olinares, B.T. Chait. “Native Mass Spectrometry Analysis of Affinity-Captured Endogenous Yeast RNA Exosome Complexes”, Methods Mol Biol. 2062 (2020) 357-382. [PMID: 31768985]


D. Ardeljan, X. Wang, M. Oghbaie, M.S. Taylor, D. Husband, V. Deshpande, J.P. Steranka, M. Gorbounov, W.R. Yang, B. Sie, H.B. Larman, H. Jiang, K.R. Molloy, I. Altukhov, Z. Li, W. McKerrow, D. Fenyö, K.H. Burns, J. LaCava. “LINE-1 ORF2p expression is nearly imperceptible in human cancers”, Mob DNA. 2019 Dec 31. [PMID: 31892958]

M. Wieczorek, L. Urnavicius, S.C. Ti, K.R. Molloy, B.T. Chait, T.M. Kapoor. “Asymmetric Molecular Architecture of the Human γ-Tubulin Ring Complex”, Cell. 2019 Dec 13. [PMID: 31862189] [Epub ahead of print]

S. Presslee, G.J. Slater, F. Pujos, A.M. Forasiepi, R. Fischer, K. Molloy, M. Mackie, J.V. Olsen, A. Kramarz, M. Taglioretti, F. Scaglia, M. Lezcano, J. L. Lanata, J. Southon, R. Feranec, J. Bloch, A. Hajduk, F.M. Martin, R. Salas Gismondi, M. Reguero, C. de Muizon, A. Greenwood, B.T. Chait, K. Penkman, M. Collins, R.D.E. MacPhee. “Palaeoproteomics resolves sloth relationships”, Nat Ecol Evol. 2019 Jun 6. [Epub ahead of print] [PMID: 31171860]

R. Hayama, M. Sorci, J.J. Keating IV, L.M. Hecht, J.L. Plawsky, G. Belfort, B.T. Chait, M.P. Rout. “Interactions of nuclear transport factors and surface-conjugated FG nucleoporins: Insights and limitations”, PLoS One. 2019 Jun 6. e0217897. [PMID: 31170242]

H. Jiang, M.S. Taylor, K.R. Molloy, I. Altukhov, J. LaCava. “Identification of RNase-sensitive LINE-1 Ribonucleoprotein Interactions by Differential Affinity Immobilization”, Bio Protoc. 2019 Apr 5. [PMID: 31106238]








































Protein kinase A directly phosphorylates metabotropic glutamate receptor 5 to modulate its function.

2021B. Bosch, M.A. DeJesus, N.C. Poulton, W. Zhang, C.A. Engelhart, A. Zaveri, S. Lavalette, N. Ruecker, C. Trujillo, J.B. Wallach, S. Li, S. Ehrt, B.T. Chait, D. Schnappinger, J.M. Rock. “Gen