Recent Publications

 

Host response to pathogens

  1. Yao H, Dittmann M, Peisley A, Hoffmann HH, Gilmore RH, Schmidt T, Schmid-Burgk JL, Hornung V, Rice CM, Hur S. ATP-Dependent Effector-like Functions of RIG-I-like Receptors. Mol Cell. 2015 Apr 16. pii: S1097-2765(15)00179-3. doi: 10.1016/j.molcel.2015.03.014. [Epub ahead of print].
  2. Luna JM, Scheel TK, Danino T, Shaw KS, Mele A, Fak JJ, Nishiuchi E, Takacs CN, Catanese MT, de Jong YP, Jacobson IM, Rice CM, Darnell RB. Hepatitis C virus RNA functionally sequesters miR-122. Cell. 2015 Mar 12;160(6):1099-110. doi: 10.1016/j.cell.2015.02.025.

  3. Dittmann M, Hoffmann HH, Scull MA, Gilmore RH, Bell KL, Ciancanelli M, Wilson SJ, Crotta S, Yu Y, Flatley B, Xiao JW, Casanova JL, Wack A, Bieniasz PD, Rice CM. A serpin shapes the extracellular environment to prevent influenza A virus maturation. Cell. 2015 Feb 12;160(4):631-43. doi: 10.1016/j.cell.2015.01.040.

  4. Shlomai A, Schwartz RE, Ramanan V, Bhatta A, de Jong YP, Bhatia SN, Rice CM. Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems. Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12193-8. doi: 10.1073/pnas.1412631111. Epub 2014 Aug 4.

  5. Billerbeck E, Labitt RN, Vega K, Frias-Staheli N, Dorner M, Xiao JW, Rice CM, Ploss A. Insufficient interleukin-12 signalling favours differentiation of human CD4(+) and CD8(+) T cells into GATA3(+) and GATA3(+)Tbet(+) subsets in humanized mice. Immunology. 2014 Oct;143(2):202-18.

  6. de Jong YP, Dorner M, Mommersteeg MC, Xiao JW, Balazs AB, Robbins JB, Winer BY, Gerges S, Vega K, Labitt RN, Donovan BM, Giang E, Krishnan A, Chiriboga L, Charlton MR, Burton DR, Baltimore D, Law M, Rice CM, Ploss A. Broadly neutralizing antibodies abrogate established hepatitis C virus infection.  Sci Transl Med. 2014 Sep 17;6(254):254ra129.
  7. Hoffmann F, Schmidt A, Dittmann Chevillotte M, Wisskirchen C, Hellmuth JC, Willms S, Gilmore RH, Glas J, Folwaczny M, Müller T, Berg T, Spengler U, Fitzmaurice K, Kelleher D, Reisch N, Rice CM, Endres S, Rothenfusser S.  Polymorphisms in MDA-5 link protein function to clearance of hepatitis C virus. Hepatology. 2014 Jul 30. [Epub ahead of print]

  8. Levin D, Schneider WM, Hoffmann HH, Yarden G, Busetto AG, Manor O, Sharma N, Rice CM, Schreiber G. Multifaceted activities of type 1 interferon are revealed by a receptor antagonist. Sci Signal. 2014 May 27;7(327):ra50.

  9. Sheahan TP, Imanaka N, Marukian S, Dorner M, Liu P, Ploss A, Rice CM.  Interferon lambda alleles predict innate antiviral immune responses and hepatitis C virus permissiveness. 2014 Cell Host Microbe Feb;15:190-202.
  10. Schoggins JW, MacDuff DA, Imanaka N, Gainey M, Shrestha B, Eitson J, Mar KB, Richardson B, Ratushny A, Litvak V, Dabelic R, Manicassamy B, Aitchison J, Aderem A, Elliott RM, Garcia-Sastre A, Racaniello V, Snijder E, Yokoyama W, Diamond MS, Virgin HW, Rice CM. Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity. 2014 Nature Jan;505:691-5. Epub 2013 Nov 27.
  11. Kane M, Yadav S, Bitzegeio J, Kutluay SB, Zang T, Wilson S, Schoggins JW, Rice CM, Yamashita M, Hatziioannou T, Bieniasz PD.  Mx2 is an interferon-induced inhibitor of HIV-1 infection. 2013 Nature Oct;502:563-6. Epub 2013 Oct 13. 
  12. Cheon H, Hovey-Bate E, Schoggins JW, Rice CM, Foster S, Stark GR.  IFN-alpha-dependent Increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage. 2013 EMBO Oct;32:2751-63. Epub 2013 Sep 24.
  13. Guermonprez, P, Helft J, Claser C, Deroubaix S, Karanje H, Gazumyan A, Darasse-Jèze G, Telerman SB, Breton G, Schreiber HA, Frias-Staheli N, Billerbeck E, Dorner M, Rice CM, Ploss A, Klein F, Swiecki M, Colonna M, Kamphorst AO, Meredith M, Niec R, Takacs C, Mikhail F, Hari A, Bosque D, Eisenreich T, Merad M, Shi Y, Ginhoux F, Rénia L, Urban BC, Nussenzweig MC.  Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection. 2013 Nature Med. Jun;19:730-8. Epub 2013 May 19.
  14. Billerbeck E, Horwitz JA, Labitt R, Vega K, Budell WC, Friling T, Koo GC, Rice CM, Ploss A. Characterization of human antiviral adaptive immune responses during hepatotropic virus infection in HLA-transgenic human immune system mice. 2013 J Immunol. Aug;19:1753-64. Epub 2013 Jul 5. 
  15. Charron G, Li MM, MacDonald MR, Hang HC.  Prenylome profiling reveals S-farnesylation is crucial for membrane targeting and antiviral activity of ZAP long isoform.  2013 Proc Natl Acad Sci USA Jul;110:11085-90. Epub 2013 Jun 17.
  16. Law JL, Chen C, Wong J, Hockman D, Santer DM, Frey SE, Belshe RB, Wakita T, Bukh J, Jones CT, Rice CM, Abrignani S, Tyrrell DL, Houghton M.  A Hepatitis C Virus (HCV) Vaccine Comprising Envelope Glycoproteins gpE1/gpE2 Derived from a Single Isolate Elicits Broad Cross-Genotype Neutralizing Antibodies in Humans. 2013 PLoS One 8:e59776. Epub 2013 Mar 19.
  17. Shin EC, Park SH, Nascimbeni M, Major M, Caggiari L, de Re V, Feinstone SM, Rice CM, Rehermann B. The frequency of CD127+ HCV-specific T cells but not the expression of exhaustion markers predict the outcome of acute hepatitis C virus infection. 2013 J Virol. Apr;87:4772-7. Epub 2013 Feb 6.
  18. Schoggins JW, Dorner M, Feulner M, Imanaka N, Murphy MY, Ploss A, and Rice CM.  Dengue reporter viruses reveal viral dynamics in interferon receptor deficient mice and sensitivity to interferon effectors in vitro. 2012 Proc Natl Acad Sci USA Sep;109:14610-5. Epub 2012 Aug 20.
  19. Karki S, Li MM, Schoggins JW, Tian S. Rice CM, MacDonald MR.  Multiple interferon stimulated genes synergize with the zinc finger antiviral protein to mediate anti-alphavirus activity. 2012 PlosONE 7:e37398. Epub 2012 May 16.
  20. Bogunovic D, Byun M, Durfee LA, Abhyankar A, Sanal O, Mansouri D, Salem S, Radovanovic I, Grant AV, Adimi P, Mansouri N, Okada S, Bryant VL, Kong X-F, Kreins A, Boisson B, Khalilzadeh S, Ozcelik U, Darazam IA, Schoggins JW, Rice CM, Al-Muhsen S, Vogt G, Puel A, Bustamante J, Gros P, Huibregtse JM, Abel L, Boisson-Dupuis S, and Casanova JL.  Impaired IFN-g immunity and mycobacterial disease in humans with inherited ISG15 deficiency. 2012 Science Sep;337:1684-8. Epub 2012 Aug 2. 
  21. Wilson SJ, Schoggins JW, Kutluay S, Jouvenet N, Zang T, Alim M, Liberatore R, Rice CM, Bieniasz PD. Inhibition of HIV-1 particle assembly by 2’, 3’-cylic-nucleotide 3’ phosphodiesterase. 2012 Cell Host Microbe Oct;12:585-97. 
  22. Fang TC, Schaefer U, Mecklenbrauker I, Stienen A, Dewell S, Chen MS, Rioja I, Parravicini V, Prinjha RK, Chandwani R, MacDonald MR, Lee K, Rice CM, and Tarakhovsky A. Histone H3 lysine 9 di-methylation as an epigenetic signature of the interferon response. 2012 J Exp Med. Apr;209:661-9. Epub 2012 Mar 12.
  23. Giang E, Dorner M, Prentoe JC, Dreux M, Evans MJ, Bukh J, Rice CM, Ploss A, Burton DR, Law M. Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus. Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6205-10. 
  24. Meng X, Schoggins JW, Rose L, Cao J, Ploss A, Rice CM, and Xiang Y. C7L family of poxvirus host-range genes inhibit antiviral activities induced by type I interferons and interferon regulatory factor 1. 2012 J Virol. Apr;86:4538-47. Epub 2012 Feb 15.
  25. Marukian S, Andrus L, Sheahan TP, Charles ED, Ploss A, Rice CM, Dustin LB. Hepatitis C virus induces interferon-λ and interferon-stimulated genes in primary liver cultures. 2011 Hepatology Dec;54:1913-23.
  26. Shin E-C, Park S-H, Nascimbeni M, DeMino M, Mihalik K, Major M, Veerapu NS, Heller T, Feinstone SM, Rice CM, and Rehermann B.  Delayed induction, not impaired recruitment of specific CD8 T cells causes the late onset of acute hepatitis C. 2011 Gastroenterology Aug;141:686-95. Epub 2011 May 18.
  27. Charles ED, Brunetti C, Marukian S, Ritola KD, Talal AH, Marks K, Jacobson IM, Rice CM, Dustin LB.  Clonal B cells in patients with hepatitis C virus-associated mixed cryoglobulinemia contain an expanded anergic CD21low B-cell subset. 2011 Blood May;17:5425-37. Epub 2011 Mar 18.
  28. Schoggins JW, Wilson SJ, Panis M, Murphy MY, Jones CT, Bieniasz P, Rice CM. A diverse range of gene products are effectors of the type I interferon antiviral response. 2011 Nature Apr;472:481-5. Epub 2011 Apr 10. 
  29. Yi Z, Sperzel L, Nürnberger C, Bredenbeek PJ, Lubick KJ, Best SM, Stoyanov CT, Law LMJ, Yuan Z, Rice CM, MacDonald MR. Identification and characterization of the host protein DNAJC14 as a broadly active flavivirus replication modulator. 2011 PLoS Pathogens Jan;7:e1001255.
  30. Cristea IM, Rozjabek H, Molloy KR, White LL, Rice CM, Rout MP, Chait BT, MacDonald MR. Host factors associated with the Sindbis virus RNA-dependent RNA polymerase: a role for G3BP1 and G3BP2 in virus replication.  2010 J Virol. Jul;84:6720-32. Epub 2010 Apr 14.
  31. Law LMJ, Albin OR, Carroll J-WN, Jones CT, Rice CM, MacDonald MR. Identification of a dominant negative inhibitor of human zinc-finger antiviral protein (ZAP) reveals a functional endogenous pool and critical homotypic interactions. 2010 J Virol. May;84:4504-12. Epub 2010 Feb 24.
 Host response to pathogensYao H, Dittmann M, Peisley A, Hoffmann HH, Gilmore RH, Schmidt T, Schmid-Burgk JL, Hornung V, Rice CM, Hur S. ATP-Dependent Effector-like Functions of RIG-I-