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Laboratory of Virology and Infectious Disease

Viral Genomes

Flaviviridae and Togaviridae genomes are positive-sense RNA molecules, meaning that they resemble cellular messenger RNAs. They are translated into long polyproteins, which are then cleaved into individual proteins. Structural proteins make up the virus particles and are labeled in yellow. Nonstructural proteins are involved in RNA replication and assembly, and are labeled in green. Roll over the gene name with your mouse to see what is known about the proteinÂ’s function.


Hepacivirus (~9600 bases)
eg. hepatitis C virus

Core E1 E2 p7 NS2 NS3 NS4A NS4B NS5A NS5B

Flavivirus (~11000 bases)
eg. yellow fever virus, West Nile virus, dengue virus

Capsid prM E NS1 NS2A NS2B NS3 NS4A NS4B NS5

Pestivirus (~12300 bases)

eg. bovine viral diarrhea virus, classical swine fever virus


Npro Core Erns E1 E2 p7 NS2 NS3 NS4A NS4B NS5A NS5B


Alphavirus (~11000 bases)
eg. Sindbis virus, Semiliki Forest virus

nsP1 nsP2 nsP3 nsP4 Capsid E3 E2 6K E1

Viral Life Cycles

Click here to watch a video of the life cycle of hepatitis C virus, an example of the family Flaviviridae.

Click here to learn more about the life cycles of the Togaviridae.