Recent publications

Animal models of virus infection

  1. Scull MA, Shi C, de Jong YP, Gerold G, Ries M, von Schaewen M, Donovan BM, Labitt RN, Horwitz JA, Gaska JM, Hrebikova G, Xiao JW, Flatley B, Fung C, Chiriboga L, Walker CM, Evans DT, Rice CM, Ploss A. Hepatitis C virus infects rhesus macaque hepatocytes and simianized mice. Hepatology. 2015 Mar 26. doi: 10.1002/hep.27773. [Epub ahead of print]
  2. Billerbeck E, Labitt RN, Vega K, Frias-Staheli N, Dorner M, Xiao JW, Rice CM, Ploss A. Insufficient interleukin-12 signalling favours differentiation of human CD4(+) and CD8(+) T cells into GATA3(+) and GATA3(+)Tbet(+) subsets in humanized mice. Immunology. 2014 Oct;143(2):202-18.
  3. Vercauteren K, Van Den Eede N, Mesalam A, Belouzard S,  Catanese MT, Wong-Staal F, Dubuisson J, Rice CM, Pietschmann T, Leroux-Roels G, Nicosia A, Meuleman P.  Successful anti-SR-B1 mAb therapy in humanized mice after challenge with HCV variants with in vitro resistance to SR-B1-targeting agents. 2014 Hepatology, May 3. [Epub ahead of print].
  4. Billerbeck E, Labitt RN, Vega K, Frias-Staheli N, Dorner M, Xiao J, Rice CM, Ploss A. Insufficient IL-12 signaling favors differentiation of human CD4+ and CD8+ T cells into GATA-3+ and GATA-3+ T-bet+ subsets in humanized mice. 2014 Immunology Apr 25. [Epub ahead of print.]
  5. Frias-Staheli N, Dorner M, Marukian S, Billerbeck E, Labitt RN, Rice CM, Ploss A. Utility of humanized BLT mice for analysis of dengue virus infection and antiviral drug testing. 2014 J Virol. Feb;88:2205-18. Epub 2013 Dec 11.
  6. Horwitz JA, Halper-Stromberg A, Mouquet H, Gitlin AD, Tretiakova A, Eisenreich TR, Malbec M, Gravemann S, Billerbeck E, Dorner M, Buning H, Schwartz O, Knops E, Kaiser R, Seaman MS, Wilson JM, Rice CM, Ploss A, Bjorkman PJ, Klein F, Nussenzweig MC. HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice. 2013 Proc Natl Acad Sci USA Oct;110:16538-43. Epub 2013 Sep 16.
  7. Billerbeck E, Horwitz JA, Labitt R, Vega K, Budell WC, Friling T, Koo GC, Rice CM, Ploss A. Characterization of human antiviral adaptive immune responses during hepatotropic virus infection in HLA-transgenic human immune system mice. 2013 J Immunol. Aug;19:1753-64. Epub 2013 Jul 5.
  8. Dorner M, Horwitz JA, Donovan BM, Labitt RN, Budell WC, Friling T, Vogt A, Catanese MT, Taniguchi T, Satoh T, Kawai T, Akira S, Law M, Rice CM, Ploss A. Completion of the entire hepatitis C virus life-cycle in genetically humanized mice. 2013 Nature Sep;501:237-41. Epub 2013 Jul 31.
  9. Vogt A, Scull MA, Friling T, Horwitz JA, Donovan BM, Dorner M, Gerold G, Labitt RN, Rice CM, Ploss A. Recapitulation of the hepatitis C virus life-cycle in engineered murine cell lines. 2013 Virology Sep;444:1-11.  Epub 2013 Jun 16.
  10. Kapoor A, Simmonds P, Scheel T, Hjelle B, Cullen J, Burbelo P, Chauhan L, Duraisamy R, Leon MS, Jain K, Vandegrift KJ, Calisher C, Rice CM, Lipkin WI. Identification of rodent homologs of hepatitis C virus and pegiviruses. 2013 mBio Apr;4:e00216-13.
  11. Dorner M, Horwitz JA, Robbins JB, Barry WT, Feng Q, Mu K, Jones CT, Schoggins JW, Catanese MT, Burton DR, Law M, Rice CM, Ploss A. A genetically humanized mouse model for hepatitis C virus infection. 2011 Nature Jun;474:208-11.
  12. Washburn ML, Bility MT, Zhang L, Kovalev GI, Buntzman A, Frelinger JA, Barry W, Ploss A, Rice CM, Su L. A humanized mouse model to study hepatitis C virus infection, immune response, and liver disease. 2011 Gastroenterology Apr;140:1334-44. Epub 2011 Jan 13.
  13. Billerbeck E, Barry WT, Mu K, Dorner M, Rice CM, Ploss, A. Development of human CD4+FoxP3+ regulatory T cells in human stem cell factor, GM-CSF and interleukin 3 expressing NOD SCID IL2RgNULL humanized mice. 2011 Blood Mar;17:3076-86. Epub 2011 Jan 20. 
  14. Strowig T, Gurer C, Ploss A, Liu YF, Arrey F, Sashihara J, Koo G, Rice CM, Young JW, Chadburn A, Cohen JI, Münz C. Priming of protective and tumor specific T cell responses in mice with human immune system components. 2009 J Exp Med. Jun;206:1409-22. Epub 2009 Jun 1.
Animal models of virus infectionScull MA, Shi C, de Jong YP, Gerold G, Ries M, von Schaewen M, Donovan BM, Labitt RN, Horwitz JA, Gaska JM, Hrebikova G, Xiao JW, Flatley B, Fung C, Chiriboga L, Wa