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  103. Jiang, Y., MacKinnon, R. (2000). The barium site in a potassium channel by x-ray crystallography. J Gen Physiol, 115(3), 269-272. PMID: 10694255; PMCID: 2217209. Full Text:
  104. Imredy, J.P., MacKinnon, R. (2000). Energetic and structural interactions between d-dendrotoxin and voltage-gated potassium channel. J Mol Biology, 296(5), 1283-1294. PMID: 10698633. Full Text:
  105. Morrill, J.A., MacKinnon, R. (1999). Isolation of a single carboxyl-carboxylate proton binding site in the pore of a cyclic nucleotide-gated channel.  J Gen. Physiol, 114(1), 71-84. PMID: 10398693; PMCID: 2229637.
  106. Roux, B., MacKinnon, R. (1999). The cavity and pore helices in the KcsA K+ channel: electrostatic stabilization of monovalent cations.  Science, 285(5424), 100-102. PMID: 10390357.
  107. Gulbis, J.M., Mann, S., MacKinnon, R. (1999). Structure of a voltage-dependent K+ channel ß subunit. Cell, 97(7), 943-952. PMID: 10399921.
  108. Morais Cabral, J.H., Lee, A., Cohen, S.L., Chait, B.T., Li, M., MacKinnon, R. (1998). Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain. Cell, 95(5), 649-655. PMID: 9845367.
  109. Imredy, J., Chen, C., MacKinnon, R. (1998). A snake toxin inhibitor of inward rectifier potassium channel ROMK1. Biochemistry, 37(42), 14867-14874. PMID: 9778362.
  110. MacKinnon, R., Cohen, S.L., Kuo, A., Lee, A., Chait, B.T. (1998). Structural conservation in prokaryotic and eukaryotic potassium channels. Science, 280(5360), 106-109. PMID: 9525854.
  111. Doyle, D.A., Cabral, J.M., Pfuetzner, R.A., Kuo, A., Gulbis, J.M., Cohen, S.L., Chait, B.T., MacKinnon, R. (1998). The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science, 280(5360): 69-77. PMID: 9525859.  Full Text:
  112. Lu, Z., MacKinnon, R. (1997). Purification, characterization, and synthesis of an inward-rectifier K+ channel inhibitor from scorpion venom.  Biochemistry, 36(23), 6936-6940. PMID: 9188688.
  113. Swartz, K.J., MacKinnon, R. (1997). Mapping the receptor site for Hanatoxin, a gating modifier of voltage-dependent K+ channels. Neuron, 18(4), 675-682. PMID: 9136775.
  114. Swartz, K.J., MacKinnon, R. (1997). Hanatoxin modifies the gating of a voltage-dependent K+ channel through multiple binding sites. Neuron, 18(4), 665-673. PMID: 9136774.
  115. Doyle, D.A., Lee, A., Lewis, J., Kim, E., Sheng, M., MacKinnon, R. (1996). Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ. Cell, 85(7), 1067-1076. PMID: 8674113.
  116. Aggarwal, S.K., MacKinnon, R. (1996). Contribution of the S4 segment to gating charge in the Shaker K+ channel. Neuron, 16(6), 1169-1177. PMID: 8663993.
  117. Gross, A., MacKinnon, R. (1996). Agitoxin footprinting the Shaker potassium channel pore. Neuron, 16(2), 399-406. PMID: 8789954.
  118. Ranganathan, R., Lewis, J., MacKinnon, R. (1996). Spatial localization of the K+ channel selectivity filter by mutant cycle-based structure analysis. Neuron, 16(1), 131-139. PMID: 8562077.
  119. Park, C.S., MacKinnon, R. (1995). Divalent cation selectivity in a cyclic nucleotide-gated ion channel. Biochemistry, 34(41). 13328-13333. PMID: 7577917.
  120. Lu, Z., MacKinnon, R. (1995). Probing a potassium channel pore with an engineered protonatable site. Biochemistry, 34(40), 13133-13138. PMID: 7548074.
  121. Swartz, K., MacKinnon, R. (1995). An Inhibitor of the Kv2.1 potassium channel isolated from the venom of a Chilean tarantula. Neuron, 15(4), 941-949. PMID: 7576642.
  122. Krezel, A., Khasibhatla, C., Hidalgo, P., MacKinnon, R., Wagner, G. (1995). Solution structure of the potassium channel inhibitor agitoxin 2:  Caliper for probing channel geometry. Protein Science, 4(8), 1478-1489. PMID: 8520473.
  123. Hidalgo, P., MacKinnon, R. (1995). Revealing the architecture of a K+ channel pore through mutant cycles with a peptide inhibitor. Science, 268(5208), 307-310. PMID: 7716527.
  124. Gross, A., Abramson, T., MacKinnon, R. (1994). Transfer of the scorpion toxin receptor to an insensitive potassium channel. Neuron, 13(4), 961-966. PMID: 7946339.
  125. Lu, Z., MacKinnon, R. (1994). Electrostatic tuning of Mg2+ affinity in an inward-rectifier K+ channel. Nature, 371(6494), 243-246. PMID: 7915826.
  126. Root, M.J., MacKinnon, R. (1994). Two identical noninteracting sites in an ion channel revealed by proton transfer. Science, 265(5180), 1852-1856. PMID: 7522344.
  127. Lu, Z., MacKinnon, R. (1994). A conductance maximum observed in an inward-rectifier potassium channel. J Gen Physiol, 104(3), 477-486. PMID: 7807057.
  128. Garcia, M.L., Garcia-Calvo, M., Hidalgo, P., Lee, A., MacKinnon, R. (1994). Purification and characterization of three inhibitors of voltage-dependent K+ channels from Leiurus Quinquestriatus var. Hebraeus venom.  Biochemistry, 33(22), 6834-6839. PMID: 8204618.
  129. Heginbotham, L., Lu, Z., Abramson, T., MacKinnon, R. (1994). Mutations in the K+ channel signature sequence. Biophysical J, 66(4), 1061-1067. PMID: 8038378.
  130. MacKinnon, R., Aldrich, R.W., Lee, A.W. (1993). Functional stoichiometry of Shaker potassium channel inactivation. Science, 262(5134), 757-759. PMID: 7694359.
  131. Heginbotham, L., MacKinnon, R. (1993). Conduction properties of the cloned Shaker K+ channel. Biophysical J, 65(5), 2089-2096. PMID: 8298038.
  132. Root, M., MacKinnon, R. (1993). Identification of an external divalent cation-binding site in the pore of a cGMP-activated channel. Neuron, 11(3), 459-466. PMID: 7691102.
  133. Perozo, E., MacKinnon, R., Bezanilla, F., Stefani, E. (1993). Gating currents from a nonconducting mutant reveal open-closed conformations in Shaker K+ channels.  Neuron, 11(2), 353-358. PMID: 8352943.
  134. Escobar, L., Root, M., MacKinnon, R. (1993). Influence of protein surface charge on the bimolecular kinetics of a potassium channel peptide inhibitor. Biochemistry, 32(27), 6982-6987. PMID: 7687466.
  135. Heginbotham, L., Abramson, T., MacKinnon, R. (1992). A functional connection between the pores of distantly related ion channels as revealed by mutant K+ channels. Science, 258(5085), 1152-1155. PMID: 1279807.
  136. Heginbotham, L., MacKinnon, R. (1992). The aromatic binding site for tetraethylammonium ion on potassium channels. Neuron, 8(3), 483-491. PMID: 1550673.
  137. MacKinnon, R. (1991). Determination of the subunit stoichiometry of a voltage-activated potassium channel. Nature, 350(6315), 232-235. PMID: 1706481.
  138. Yellen, G., Jurman, M., Abramson, T., MacKinnon, R. (1991). Mutations affecting internal TEA blockade identify the probable pore-forming region of a K+ channel. Science, 251(4996), 939-942. PMID: 2000494.
  139. MacKinnon, R., Yellen, G. (1990). Mutations affecting TEA blockade and ion permeation in voltage-activated K+ channels. Science, 250(4978), 276-279. PMID: 2218530.
  140. MacKinnon, R., Heginbotham, L., Abramson, T. (1990). Mapping the receptor site for charybdotoxin, a pore-blocking potassium channel inhibitor. Neuron, 5(6): 767-771. PMID: 1702643.
  141. Schumaker, M., MacKinnon, R. (1990). A simple model for multi-ion permeation:  single-vacancy conduction in a simple pore model. Biophysical J, 58(4), 975-984. PMID: 1701102.
  142. MacKinnon, R., Miller, C. (1989). Mutant potassium channels with altered binding of charybdotoxin, a pore-blocking peptide inhibitor. Science, 245(4924), 1382-1385. PMID: 2476850.
  143. MacKinnon, R., Latorre R, Miller, C. (1989). Role of surface electrostatics in the operation of a high-conductance Ca2+-activated K+ channel.  Biochemistry, 28(20), 8092-8099. PMID: 2605175.
  144. MacKinnon, R., Miller, C. (1989). Functional modification of Ca2+-activated K+ channel by trimethyloxonium. Biochemistry, 28(20), 8087-8092. PMID: 2481495.
  145. MacKinnon, R., Reinhart, P., White, M. (1988). Charybdotoxin block of Shaker K+ channels suggests that different types of K+ channels share common structural features.  Neuron, 1(10), 997-1001. PMID: 2483094.
  146. MacKinnon, R., Miller, C. (1988). Mechanism of charybdotoxin block of the high-conductance Ca2+-activated K+ channel. J Gen Physiol, 91(3), 335-349. PMID: 2454283.
  147. Anderson, C.S., MacKinnon, R., Smith, C., Miller, C. (1988). Charybdotoxin block of single Ca2+- activated K+ channels: Effects of channel gating, voltage, and ionic strength. J Gen Physiol, 91(3), 317-333. PMID: 2454282.
  148. MacKinnon, R., Gwathmey, J., Allen, P., Briggs, M., Morgan, J.P. (1988). Modulation by the thyroid state of intracellular calcium and contractility in ferret ventricular muscle. Circ Res, 63(6), 1080-1089. PMID: 3197273.
  149. MacKinnon, R., Gwathmey, J., Morgan, J.P. (1987). Differential effects of reoxygenation on intracellular calcium and isometric tension. Pflugers Arch, 409(4-5), 448-453. PMID: 3627961.
  150. Gwathmey JK, Copelas L, MacKinnon R, Schoen FJ, Feldman MD, Grossman W, Morgan JP. Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure. Circ Res. 1987 Jul;61(1):70-6. PMID: 3608112.
  151. MacKinnon, R., Morgan, J.P. (1986). Influence of the thyroid state on the calcium transient in ventricular muscle. Pflugers Arch, 407(2), 142-144. PMID: 2428004.

 Review Articles:

  1. Gouaux, E., MacKinnon, R. (2005). Principles of selective ion transport in channels and pumps. Science, 310(5753), 1461-1465. PMID: 16322449.
  2. MacKinnon, R. (2005). Membrane protein insertion and stability. Science, 307(5714), 1425-1426. PMID: 15746418.
  3. MacKinnon, R. (2004). Voltage sensor meets lipid membrane. Science, 306(5700), 1304-1305. PMID: 15550651.
  4. MacKinnon, R. (2004). Potassium channels and the atomic basis of selective ion conduction (Nobel Lecture). Angew Chem Int Ed Engl, 43(33), 4265-4277. PMID: 15368373.
  5. MacKinnon, R. (2003). Potassium channels. FEBS Letter 555(1), 62-65. PMID: 14630320.
  6. MacKinnon, R. (1995). Pore loops: an emerging theme in ion channel structure. Neuron, May; 14(5), 889-92. PMID: 7538310.
Falzone M., MacKinnon R. (2023) The mechanism of Gαq regulation of PLCβ3-catalyzed PIP2 hydrolysis. PNAS, Nov 28;120(48):e2315011120. doi: 10.1073/pnas.2315011120. PMID: 37991948. Epub 20