Laboratory of Virology and Infectious Disease
Flaviviridae and Togaviridae genomes are positive-sense RNA molecules, meaning that they resemble cellular messenger RNAs. They are translated into long polyproteins, which are then cleaved into individual proteins. Structural proteins make up the virus particles and are labeled in yellow. Nonstructural proteins are involved in RNA replication and assembly, and are labeled in green. Roll over the gene name with your mouse to see what is known about the proteinÂ’s function.
Hepacivirus (~9600 bases)
eg. hepatitis C virus
Flavivirus (~11000 bases)
eg. yellow fever virus, West Nile virus, dengue virus
Pestivirus (~12300 bases)
eg. bovine viral diarrhea virus, classical swine fever virus
Alphavirus (~11000 bases)
eg. Sindbis virus, Semiliki Forest virus
Viral Life Cycles
Click here to watch a video of the life cycle of hepatitis C virus, an example of the family Flaviviridae.
Click here to learn more about the life cycles of the Togaviridae.