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G. Suidan, P.K. Singh, S. Patel-Hett, Z.L. Chen, D. Volfson, H. Yamomoto-Imoto, E.H. Norris, R. Bell, S. Strickland. "Abnormal clotting of the intrinsic/contact pathway in Alzheimer’s disease patients is related to cognitive ability." Blood Advances (2018) In Press. 

P.K. Singh, M. Kawasaki, H. Berk-Rauch, G. Nishida, T. Yamasaki, M. Foley, E.H. Norris, S. Strickland, K. Aso, H.J. Ahn. "Aminopyrimidine class aggregation inhibitor effectively blocks AΒ-fibrinogen interaction and AΒ-induced contact system activation."  Biochemistry (2018), 57, 1399-1409. 

S. Strickland. "Blood will out: Vascular contributions to Alzheimer's disease." J Clin Invest (2018), 128, 556-563.

E.H. Norris and S. Strickland. "Fibrinogen in the Nervous System: Glia Beware." Neuron (2017), 96, 951-953.

H.J. Ahn, Z.L. Chen, D. Zamolodchikov, E.H. Norris, S. Strickland. "Interactions of beta-amyloid peptide with fibrinogen and coagulation factor XII may contribute to Alzheimer's disease."Curr Opin Hematol (2017), 24, 427-431. 

Z.L Chen, A.S Revenko, P. Singh, A.R. MacLeod, E.H. Norris, S. Strickland. "Depletion of coagulation factor XII ameliorates brain pathology and cognitive impairment in Alzheimer's disease mice." Blood (2017), 129, 2547-2556.

D. Zamolodchikov, H.E. Berk-Rauch, D.A. Oren, D.S. Stor, P.K. Singh, M. Kawasaki, K. Aso, S. Strickland, H.J. Ahn. "Biochemical and structural analysis of the interaction between beta-amyloid and fibrinogen." Blood. (2016), 128, 1144-1151.

Y.C. Chung, A. Kruyer, Y. Yao, E. Feierman, A. Richards, S. Strickland, E.H. Norris. "Hyperhomocysteinemia exacerbates Alzheimer’s disease pathology by way of the Aβ-fibrinogen interaction." J Thromb Haemost. (2016), 14, 1442-1452. 

Y. Yao, E.H. Norris, C. Mason, S. Strickland. "Laminin regulates PDGFRβ+ cell stemness and muscle development." Nat Comm, (2016), 7, 11415.

D. Zamolodchikov, T. Renne, S. Strickland. "The Alzheimer’s disease peptide Aβ promotes thrombin generation through activation of coagulation factor XII." J Thromb Haemost, 13 (2015) 1-13. 

A. Kruyer, N. Soplop, S. Strickland, E.H. Norris. "Chronic hypertension leads to neurodegeneration in the TgSwDI mouse model of Alzheimer's disease." Hypertension, 66 (2015) 175-182. 

D. Zamolodchikov, Z.L. Chen, B.A. Conti, T. Renne, S. Strickland. "Activation of the factor XII-driven contact system in Alzheimer's disease patient and mouse model plasma." Proc. Natl. Acad. Sci., 112 (2015) 4068-4073. 

M. Cortes-Canteli, L. Mattei, A.T. Richards, E.H. Norris, S. Strickland. "Fibrin deposited in the Alzheimer's disease brain promotes neuronal degeneration." Neurobiol Aging, 36 (2015) 608-617.

Y. Yao, E.H. Norris, S. Strickland. "The cellular origin of laminin determines its role in blood pressure regulation." Cell Mol Life Sci, 72 (2015) 999-1008. 

H.J. Ahn, J.F. Glickman, K.L. Poon, D. Zamolodchikov, O.C. Jno-Charles, E.H. Norris, S. Strickland. "A novel Abeta-fibrinogen interaction inhibitor rescues altered thrombosis and cognitive decline in Alzheimer's disease mice." J Ex Med, 211 (2014) 1049-1062.

K. Hultman, M. Cortes-Canteli, A. Bounoutas, A. Richards, S. Strickland, E.H. Norris. "Plasmin deficiency leads to fibrin accumulation and a compromised inflammatory response in the mouse brain." J Thromb Haemost, 12 (2014) 701-712.  

Y. Yao, Z.L. Chen, E.H. Norris, S. Strickland. "Astrocytic laminin regulates pericyte differentiation and maintains blood brain barrier integrity." Nat Comm, 5 (2014) 3413.

Z.L. Chen, Y. Yao, E.H. Noris, A. Kruyer, O. Jno-Charles, A. Akhmerov, S. Strickland. "Ablation of astrocytic laminin impairs vascular smooth muscle cell function and leads to hemorrhagic stroke."  J Cell Biol, 202 (2013) 381-395.

K. Hultman, S. Strickland, E.H. Norris. "The APOE ε4/ε4 genotype potentiates vascular fibrin(ogen) deposition in amyloid-laden vessels in the brains of Alzheimer’s disease patients." J Cereb Blood Flow Metab, 33 (2013) 1251-1258.

E.R. Lowry, A. Kruyer, E.H. Norris, C.R. Cederroth, S. Strickland. "The GLUK4 kainate receptor subunit regulates memory, mood, and excitotoxic neurodegeneration." Neurosci, 235 (2013) 215-225. 

M. Cortes-Canteli, D. Zamolodchikov, H.J. Ahn, S. Strickland, E.H. Norris. "Fibrinogen and altered hemostasis in Alzheimer's disease." J Alz Dis, 32 (2012) 59-608.

D. Zamolodchikov & S. Strickland. "Beta-amyloid delays fibrin clot lysis by altering fibrin structure and attenuating plasminogen binding to fibrin." Blood, 119 (2012) 3342-3351.

M. Noel, E.H. Norris, S. Strickland. "Tissue plasminogen activator is required for the development of fetal alcohol syndrome in mice." Proc. Natl. Acad. Sci., 108 (2011) 5069-5074.

H.J. Ahn, D. Zamolodchikov, M. Cortes-Canteli, E.H. Norris, J.F. Glickman, S. Strickland. "The Alzheimer's disease peptide beta-amyloid interacts with fibrinogen and induces its oligomerization." Proc. Natl. Acad. Sci., 107 (2010) 21812-21817.

K. Carlson, P. Singh, M. Feaster, A. Ramnarain, C. Pavlides, Z.-L. Chen, W.-M. Yu, M.L. Feltri, S. Strickland. "Mesenchymal stem cells facilitate axon sorting, myelination, and functional recovery in paralyzed mice deficient in Schwann-cell derived laminin." Glia, 59 (2011) 267-277.

M. Cortes-Canteli, J. Paul, E.H. Norris, R. Bronstein, H.J. Ahn, D. Zamolodchikov, S. Bhuvanendran, K.M. Fenz, S. Strickland. "Fibrinogen and beta-amyloid association alters thrombosis and fibrinolysis: a possible contributing factor to Alzheimer's disease." Neuron, 66 (2010) 695-709.

Y. Zhou, R. Maiya, E.H. Norris, M.J. Kreek, S. Strickland. "Involvement of tissue plasminogen activator in stress responsivity during acute cocaine withdrawal in mice." Stress, 13 (2010) 481-490.

P.S. Dhadialla, I.E. Ohiorhenuan, A. Cohen, S. Strickland. "Maximum-entropy network analysis reveals a role for tumor necrosis factor in peripheral nerve development and function." Proc Natl Acad Sci USA, 106 (2009) 12494-12499.

M. Cortes-Canteli & S. Strickland. "Fibrinogen, a possible key player in Alzheimer's disease." J Thromb Haemost, 7 (2009) 146-150.

A.E. Skrzypiec, R. Maiya, R. Pawlak, S. Strickland. "Plasmin-Mediated Degradation of Laminin gamma-1 Is Critical for Ethanol-Induced Neurodegeneration." Biol Psychiatry, 66 (2009) 785-794.

W.M. Yu, Z.L. Chen, A.J. North, S. Strickland. "Laminin is required for Schwann cell morphogenesis." J Cell Sci, 122 (2009) 929-936.

R. Maiya, E.H. Norris, M.J. Kreek, S. Strickland. "Tissue plasminogen activator modulates the cellular and behavioral response to cocaine." Proc Natl Acad Sci USA, 106 (2009) 1983-1988.

Z.L. Chen, V. Haegeli, H. Yu, S. Strickland. "Cortical deficiency of laminin gamma1 impairs the AKT/GSK-3beta signaling pathway and leads to defects in neurite outgrowth and neuronal migration." Dev Biol., 327 (2009) 158-168.

W.M. Yu, H. Yu, Z.L. Chen, S. Strickland. "Disruption of laminin in the peripheral nervous system impedes nonmyelinating Schwann cell development and impairs nociceptive sensory function." Glia., 57 (2009) 850-859.

Z.L. Chen, H. Yu, W.M. Yu, R. Pawlak, S. Strickland. "Proteolytic fragments of laminin promote excitotoxic neurodegeneration by up-regulation of the KA1 subunit of the kainate receptor." J Cell Biol., 183 (2008) 1299-1313.

M.A. Chernousov, W.M. Yu, Z.L. Chen, D.J. Carey, S. Strickland. "Regulation of Schwann cell function by the extracellular matrix." Glia, 56 (2008) 1498-1507.

L. Park, E.F. Gallo, J. Anrather, G. Wang, E.H. Norris, J. Paul, S. Strickland, C. Iadecola. "Key role of tissue plasminogen activator in neurovascular coupling." Proc Natl Acad Sci, 105 (2008) 1073-1078.

J. Paul, S. Strickland, J.P. Melchor. "Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease." J Exp Med, 204 (2007) 1999-2008.

E.H. Norris & S. Strickland. "Modulation of NR2B-regulated contextual fear in the hippocampus by the tissue plasminogen activator system." Proc Natl Acad Sci, 104 (2007) 13473-13478.

U. Schaefer, S. Vorlova, T. Machida, J.P. Melchor, S. Strickland, R. Levi. "Modulation of sympathetic activity by tissue plasminogen activator is independent of plasminogen and urokinase." J Pharmacol Exp Ther, 322 (2007) 265-273.

Z.L. Chen, W.M. Yu, S. Strickland. "Peripheral regeneration." Annu Rev Neurosci, 30 (2007) 209-233.

S. Bennur, B.S.S. Rao, R. Pawlak, S. Strickland, B.S. McEwen, S. Chattarji. "Stress-induced spine loss in the medial amygdala is mediated by tissue-plasminogen activator." Neurosci, 144 (2007) 8-16.

C. Ling, T. Zou, Y. Hsiao, X. Tao, Z.L. Chen, S. Strickland, H. Song. "Disruption of tissue plasminogen activator gene reduces macrophage migration." Biochem Biophys Res Commun, 349 (2006) 906-912.

U. Schaefer, T. Machida, S. Vorlova, S. Strickland, R. Levi. "The plasminogen activator system modulates sympathetic nerve function." J Exp Med 203 (2006) 2191-2200.

T. Zou, C. Ling, Y. Xiao, X. Tao, M. Da, Z.L. Chen, S. Strickland, H. Song. "Exogenous tissue plasminogen activator enhances peripheral nerve regeneration and functional recovery after injury in mice." J Neuropath Exp Neurol, 65 (2006) 78-86.

R. Pawlak, B.S.S. Rao, J.P. Melchor, S. Chattarji, B. McEwen, S. Strickland. "Tissue plasminogen activator and plasminogen mediate stress-induced decline of neuronal and cognitive functions in the mouse hippocampus." Proc Natl Acad Sci 102 (2005) 18201-18206.

S. Occhi, D. Zambroni, U. Del Carro, S. Amadio, E.E. Sirkowski, S.S.Scherer, K.P. Campbell, S.A. Moore, Z.L. Chen, S. Strickland, A. Di Muzio, A. Uncini, L. Wrabetz, M.L. Feltri. "Both laminin and Schwann cell dystroglycan are necessary for proper clustering of sodium channels at nodes of Ranvier." J Neurosci, 25 (2005) 9418-9427.

W.M. Yu, M.L. Feltri, L. Wrabetz, S. Strickland, Z.L. Chen. "Schwann cell-specific gamma1 causes apoptosis and prevents proliferation." J Neurosci, 25 (2005) 4463-4472.

J.P. Melchor & S. Strickland. "Tissue plasminogen activator in central nervous system physiology and pathology." Thromb Haemost, 93 (2005) 655-660.

R. Pawlak, J.P. Melchor, T. Matys, A.E. Skrzypiec, S. Strickland. "Ethanol-withdrawal seizures are controlled by tissue plasminogen activator via modulation of NR2B-containing NMDA receptors." Proc Natl Acad Sci, 102 (2005) 443-448.

T. Matys, R. Pawlak, E. Matys, C. Pavlides, B.S. McEwen, S. Strickland. "Tissue plasminogen activator promotes the effects of corticotrophin-releasing factor on the amygdala and anxiety-like behavior." Proc Natl Acad Sci, 101 (2004) 16345-16350.

K. Akassoglou, R. Adams, J. Bauer, P. Mercado, V. Tseveleki, H. Lassmann, L. Probert, S. Strickland. "Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis." Proc Natl Acad Sci, 17 (2004) 6698-6703.

Z.L. Chen & S. Strickland. "Laminin gamma1 is critical for Schwann cell differentiation, axon myelination and regeneration in the peripheral nerve." J Cell Biol, 163 (2003) 889-899.

J.P. Melchor, R. Pawlak, S. Strickland. "The tPA/plasminogen proteolytic cascade accelerates Aß degradation and inhibits Aß-induced neurodegeneration." J Neurosci, 23 (2003) 8867-8871.

J.P. Melchor, R. Pawlak, Z.L. Chen, S. Strickland. "The possible role of tissue-type plasminogen activator (tPA) and tPA blockers in the pathogenesis and treatment of Alzheimer's disease." J Mol Neurosci, 20 (2003) 287-289.

Z.L. Chen, J.A. Indyk, S. Strickland. "The hippocampal laminin matrix is dynamic and critical for neuronal survival." Mol Biol Cell, 14 (2003) 2665-2676.

J.A. Indyk, Z.L. Chen, S.E. Tsirka, S. Strickland. "Laminin chain expression suggests that laminin-10 is a major isoform in the mouse hippocampus and is degraded by the tPA/plasmin protease cascade during excitotoxic injury." Neuroscience, 116 (2003) 359-371.

T. Matys & S. Strickland. "Tissue plasminogen activator and NMDA receptor cleavage." Nature Med, 9 (2003) 371-372.

K. Akassoglou, P. Akpinar, S. Murray, S. Strickland. "Fibrin is a regulator of Schwann cell migration after sciatic nerve injury in mice." Neurosci Lett 338 (2003) 185-188.

R. Pawlak, A.M. Magarinos, J. Melchor, B.S. McEwen, S. Strickland. "Tissue plasminogen activator in the amygdala is critical for stress-induced anxiety-like behavior." Nature Neurosci 6 (2003) 168-174.

K. Akassoglou, W.M. Yu, P. Akpinar, S. Strickland. "Fibrin inhibits peripheral nerve remyelination by regulating Schwann cell differentiation." Neuron, 33 (2002) 861-875.

F. Sallés & S. Strickland. "Localization and regulation of the tissue plasminogen activator/plasmin system in the hippocampus." J Neurosci, 22 (2002) 2125-2134.

E. Harms, T. Chu, G. Henrion, S. Strickland. "The only function of grauzone required for Drosophila oocyte meiosis is transcriptional activation of the cortex gene." Genetics, 155 (2000) 1831-1839.

K. Akassoglou, K. Kombrinck, J.L. Degen, S. Strickland. "Tissue plasminogen activator-mediated fibrinolysis protects against axonal degeneration and demyelination after sciatic nerve injury." J Cell Biol, 149 (2000) 1157-1166.

B. Chen, E. Harms, T. Chu, G. Henrion, S. Strickland. "Completion of meiosis in Drosophila oocytes requires transcriptional control by grauzone, a new zinc finger protein." Development, 127 (2000) 1243-1251.

Z.L. Chen, J.A. Indyk, K.W. Kombrinck, J.L. Degen, S. Strickland. "Neuronal death and blood-brain barrier breakdown after excitotoxic injury are independent processes." J Neurosci, 19 (1999) 9813-9820.

B. Chen, T. Chu, E. Harms, J.P. Gergen, S. Strickland. "Mapping of Drosophila mutations using site-specific male recombination." Genetics, 149 (1998) 157-163.

Y.F. Wang, S.E. Tsirka, S. Strickland, P.E. Stieg, S.G. Soriano, S.A. Lipton. "Tissue plasminogen activator (tPA) increases neuronal damage after focal ischemia in wild-type and tPA-deficient mice." Nature Med, 4 (1998) 228-231.

Z.L. Chen & S. Strickland. "Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of laminin." Cell, 91 (1997) 917-925.

S.E. Tsirka, A.D. Rogove, T.H. Bugge, J.L. Degen, S. Strickland. "An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus." J Neurosci, 17 (1997) 543-552.

S.E. Tsirka, A.D. Rogove, S. Strickland. "Neuronal death and tissue plasminogen activator." Nature, 384 (1996) 123-124.

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G. Suidan, P.K. Singh, S. Patel-Hett, Z.L. Chen, D. Volfson, H. Yamomoto-Imoto, E.H. Norris, R. Bell, S. Strickland. "Abnormal clotting of the intrinsic/contact pathway in Alzheimer’s disease p