Publications

Mutations of the SLX4 gene in Fanconi anemia.
Kim Y, Lach FP, Desetty R, Hanenberg H, Auerbach AD, Smogorzewska A.
Nat Genet. 2011 Jan 16. [Epub ahead of print]

A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair.
Smogorzewska A, Desetty R, Saito TT, Schlabach M, Lach FP, Sowa ME, Clark AB, Kunkel TA, Harper JW, Colaiácovo MP, Elledge SJ.
Mol Cell. 2010 Jul 9;39(1):36-47.

The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair.
Knipscheer P, Räschle M, Smogorzewska A, Enoiu M, Ho TV, Schärer OD, Elledge SJ, Walter JC.
Science. 2009 Dec 18;326(5960):1698-701. Epub 2009 Nov 12.

Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.
Svendsen JM, Smogorzewska A, Sowa ME, O'Connell BC, Gygi SP, Elledge SJ, Harper JW.
Cell. 2009 Jul 10;138(1):63-77.

FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway.
Ishiai M, Kitao H, Smogorzewska A, Tomida J, Kinomura A, Uchida E, Saberi A, Kinoshita E, Kinoshita-Kikuta E, Koike T, Tashiro S, Elledge SJ, Takata M.
Nat Struct Mol Biol. 2008 Nov;15(11):1138-46. Epub 2008 Oct 19.

Cancer proliferation gene discovery through functional genomics.
Schlabach MR, Luo J, Solimini NL, Hu G, Xu Q, Li MZ, Zhao Z, Smogorzewska A, Sowa ME, Ang XL, Westbrook TF, Liang AC, Chang K, Hackett JA, Harper JW, Hannon GJ, Elledge SJ.
Science. 2008 Feb 1;319(5863):620-4. Erratum in: Science.2008 Apr 18;320(5874):316.

Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response.
Wang B, Matsuoka S, Ballif BA, Zhang D, Smogorzewska A, Gygi SP, Elledge SJ.
Science. 2007 May 25;316(5828):1194-8.

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER 3rd, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ.
Science. 2007 May 25;316(5828):1160-6.

Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair.
Smogorzewska A, Matsuoka S, Vinciguerra P, McDonald ER 3rd, Hurov KE, Luo J, Ballif BA, Gygi SP, Hofmann K, D'Andrea AD, Elledge SJ.
Cell. 2007 Apr 20;129(2):289-301. Epub 2007 Apr 5.