Selected Publications (2000-present)

  1. Allis, C.D., Jenuwein, T., Reinberg, D. (eds.), Caparros, M.L. (assoc. ed.) Epigenetics Cold Spring Harbor Laboratory Press. Cold Spring Harbor, NY, 2006
  2. Strahl, B.D. and Allis, C.D. (2000) The language of covalent histone modifications. Nature 403, 41-45
  3. Cheung, P., Allis, C.D. and Sassone-Corsi, P. (2000) Signaling to chromatin through histone modifications. Cell 103, 263-271
  4. Jenuwein, T. and Allis, C.D. (2001) Translating the histone code. Science 293, 1074-1080
  5. Wysocka, J., Swigut, T., Xiao, H., Landry, J., Kauer, M., Tackett, A., Chait, B., Brivanlou, A.H., Wu, C. and Allis, C.D. (2006) A PHD finger in the largest subunit of NURF couples histone H3 K4 trimethylation with chromatin remodeling. Nature 442, 86-90
  6. Taverna, S.D., Ilin, S., Rogers, R.S., Tanny, J.C., Lavender, H., Li, H., Baker, L., Boyle, J., Blair, L.P., Chait, B.T., Patel, D.J., Aitchison, J.D., Tackett, A.J. and Allis, C.D. (2006) Yng1 PHD finger binding to histone H3 trimethylated at lysine 4 targets lysine 14 specific NuA3 HAT activity to a subset of promoters for transcriptional activation. Mol. Cell 24, 1-12
  7. Li, H., Ilin, S., Wang, W.-K., Wysocka, J., Allis, C.D. and Patel, D.J. (2006) Molecular basis for site/state-specific readout of histone lysine-methylation marks by the PHD domain of BPTF. Nature 442, 91-95
  8. Ruthenburg, A., Allis, C.D., Wysocka, J. (2007a) Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark. Mol. Cell. 25, 15-37.
  9. Ruthenburg, A.J., Li, H., Patel, D.J., Allis, C.D. (2007b) Multivalent engagement of chromatin modifications by linked binding modules. Nat Rev Mol Cell Biol, 12: 983-994
  10. Taverna, S.D., Li, H., Ruthenburg, A.J., Allis, C.D., Patel, D.J. (2007) How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers. Nat Struct Mol Biol, 14: 1025-1040
  11. Baker, L.A., Allis, C.D. and Wang, G.G. (2008) PHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks. Mutat. Res. 647, 3-12
  12. Fischle, W., Wang, Y. and Allis, C.D. (2003) Binary switches and modification cassettes in histone biology and beyond. Nature 425, 475-479
  13. Fischle, W., Tseng, B.S., Dormann, H., Ueberheide, B.M., Garcia, B.A., Shabanowitz, J., Hunt, D.F., Funabiki, H. and Allis, C.D. (2005) Regulation of HP1-chromatin binding by histone H3 methylation and phosphorylation. Nature 438, 1116-1122
  14. Cheung, W.L., Ajiro, K., Kloc, M., Cheung P., Mizzen, C.A., Beeser, A., Etkin, L.D., Chernoff, J. and Allis, C.D. (2003) Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. Cell 16, 507-517 (featured article)
  15. Ahn, S.-H., Cheung, W.L., Hsu, J.-Y., Smith, M.M. and Allis, C.D. (2005) Sterile 20 kinase phosphorylates histone H2B at serine10 during hydrogen peroxide-induced apoptosis in S. cerevisiae. Cell 120, 25-36
  16. Ahn, S., Diaz, R.L., Grunstein, M., Allis, C.D. (2006) Histone H2B deacetylation at lysine 11 is required for yeast apoptosis induced by phosphorylation of H2B at serine 10. H2B. Mol. Cell 24, 211-220
  17. Wang, G.G., Allis, C.D., Chi, P. (2007a) Chromatin remodeling and cancer: part I - covalent histone modifications. Trends in Molecular Medicine 13, 363-372
  18. Wang, G.G., Allis, C.D., Chi, P. (2007b) Chromatin remodeling and cancer: part II - ATP-dependent chromatin remodeling. Trends in Molecular Medicine 13, 373-380
  19. Sun, Z.-W. and Allis, C.D. (2002) Ubiquitylation of histone H2B regulates H3 methylation and gene silencing in yeast. Nature 418, 104-108
  20. Briggs, S.D., Xiao, T., Sun, Z.-W., Caldwell, J.A., Shabanowitz, J., Hunt, D.F., Strahl, B.D. and Allis, C.D. (2002) Gene silencing: trans-histone regulatory pathway in chromatin. Nature 418, 498
  21. Hake S.B. and Allis, C.D. (2006) Histone H3 variants and their potential role in indexing mammalian genomes: The "H3 barcode hypothesis" Proc. Natl. Acad. Sci. USA 103, 6428-6435
  22. Shechter, D., Nicklay, J., Chitta, R., Shabanowitz, J., Hunt, D.F., Allis, C.D. (2009) Analysis of histones in Xenopus laevis, Part I: A distinct index of enriched variants and modifications exists in each cell type and is remodeled during developmental transitions. J Biol Chem 284, 1064-1074
  23. Duncan, E.M., Muratore-Shroeder, T.L., Cook, R.G., Shabanowitz, J., Hunt, D.F., Allis, C.D. (2008) Cathepsin L proteolytically processes histone H3 during mouse embryonic stem cell differentiation. Cell 135, 284-294
  24. Goldberg, A.D., Allis, C.D., Bernstein, E. (2007) Epigenetics: a landscape takes shape. Cell 128, 635-638
  25. Borrelli, E., Nestler, E. Allis, C.D., Sassone-Corsi, P. (2008) Decoding the epigenetic language of neuronal plasticity. Neuron 60, 961-974
  26. Xiao, A., Li, H., Shechter, D., Ahn, S.H., Fabrizio, L.A., Erdjument-Bromage, H., Murakami-Ishibe, S., Wang, B., Tempst, P., Hofmann, K., Patel, D.J., Elledge, S.J., Allis, C.D. (2009) WSTF regulates the DNA damage response of H2A.X via a novel tyrosine kinase activity. Nature 457, 57-62
  27. Wang, G.W., Song, J., Wang, Z., Dormann, H., Casadio, F., Li, H., Patel, D. and Allis, C.D. (2009) Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger. Nature, in press
  28. Milne, T., Kim, J., Wang, G.G., Basrur, V., Whitcomb, S., Wang, Z., Ruthenburg, A., Elenitoba-Johnson, K., Roeder, R.G. and Allis, C.D. (2010) Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis. Mol. Cell 38, 853-863
  29. Chi, P., Allis, C.D. and Wang, G. (2010) Covalent histone modifications -- mis-written, mis-interpreted and mis-erased in human cancers. Nature Reviews Cancer 10, 457-469
  30. Chi, P., Chen, Y., Zhang, L., Betley, N., Wongvipat, J., Shamu, T., Fletcher, J., Maki, R., Jessell, T., Antonescu, C., Allis, C.D. and Sawyers, C. (2010) ETV1 is a lineage-specific survival factor in gastrointestinal stromal tumours. Nature 467, 849-853
  31. Lewis, P.W., Elsaesser, S. J., Noh, K. M., Stadler, S.C. and Allis, C.D. (2010) Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telemoreres. Proc. Natl. Acad. Sci. USA 107, 14075-14080
  32. Elsaesser, S.J. and Allis, C.D. (2010) HIRA and Daxx constitute two independent histone H3.3-containing predeposition complexes. Cold Spring Harbor Symposium Quantitative Biology 75, 27-34
  33. Banaszynski, L.A., Allis, C.D. and Lewis, P.W. (2010) Histone variants in metazoan development. Dev. Cell 19, 662-674
  34. Allis, C.D. and Muir, T.W. (2011) Spreading chromatin into chemical biology. ChemBioChem. 12, 264-279
  35. Gardner K.E., Allis C.D. and Strahl B.D. (2011) OPERating ON chromatin, a colorful language where context matters. J. Mol. Biol. 409, 36-46
  36. Elsaesser, S.J., Allis, C.D. and Lewis, P.W. (2011) New epigenetic drivers of cancer. Science 331, 1145-1146
  37. Ruthenburg, A., Li, H., Milne, T., Dou, Y., McGinty, R., Yuen, M., Ueberheide, B., Muir, T., Patel, D. and Allis, C.D. (2011) Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions. Cell 145, 692-706