Lab Publications
Conserved Spatial Organization of FG Domains in the Nuclear Pore Complex
Claire E. Atkinson, Alexa L. Mattheyses, Martin Kampmann, and Sanford M. Simon
Biophys J. 2013 Jan 8;104(1):37-50
Dynamics of clathrin-mediated endocytosis and its requirement for organelle biogenesis in Dictyostelium
Laura Macro, Jyoti K. Jaiswal, and Sanford M. Simon
J Cell Sci. 2012 Dec 1;125(Pt 23):5721-32
Total Internal Reflection Fluorescence (TIRF) Microscopy Illuminator for Improved Imaging of Cell Surface Events
Daniel S. Johnson, Jyoti K. Jaiswall, and Sanford Simon
Curr Protoc Cytom. 2012 Jul;Chapter 12:Unit 12.29
Imaging single endocytic events reveals diversity in clathrin, dynamin and vesicle dynamics
Alexa L. Mattheyses, Claire E. Atkinson, and Sanford M. Simon
Traffic. 2011 Oct;12(10):1394-406
Simulations of nuclear pore transport yield mechanistic insights and quantitative predictions
Joshua S. Mincer, and Sanford M. Simon
Proc Natl Acad Sci U S A. 2011 Aug 2
Visualizing HIV-1 Assembly
Nolwenn Jouvenet, Sanford M. Simon, and Paul D. Bieniasz
J Mol Biol. 2011 Jul 22;410(4):501-11
Mapping the orientation of nuclear pore proteins in living cells with polarized fluorescence microscopy
Martin Kampmann, Claire E. Atkinson, Alexa L. Mattheyses, and Sanford M. Simon
Nat Struct Mol Biol. 2011 Jun;18(6):643-9
Dynamics of ESCRT protein recruitment during retroviral assembly
Nolwenn Jouvenet, Maria Zhadina, Paul D. Bieniasz, and Sanford M. Simon
NATURE CELL BIOLOGY VOLUME 13 NUMBER 4 APRIL 2011
Fluorescence Anisotropy Reveals Order and Disorder of Protein Domains
Alexa L. Mattheyses, Martin Kampmann, Claire E. Atkinson, and Sanford M. Simon
Biophysical Journal Volume 99 September 2010 1706–1717
Imaging with total internal reflection fluorescence
Alexa L. Mattheyses1, Sanford M. Simon and Joshua Z. Rappoport
Journal of Cell Science 123, 3621-3628 2010.
Viral Houseguests Undertake Interior Redesign
Nolwenn Jouvenet and Sanford M. Simon
DOI 10.1016/j.cell.2010.05.012
Spatial and Temporal Dynamics of Mitochondrial Membrane Permeability Waves during Apoptosis
Patrick D. Bhola, Alexa L. Mattheyses, and Sanford M. Simon
Biophysical Journal Volume 97 October 2009 2222–2231
Partial internal reflections on total internal reflection fluorescent microscopy
Sanford M. Simon
Trends in Cell Biology 2009 Vol.19 No.11
Imaging the interaction of HIV-1 genomes and Gag during assembly of individual viral particles
Nolwenn Jouveneta, Sanford M. Simon, and Paul D. Bieniasza
19114–19119 PNAS November 10, 2009 vol. 106 no. 45
Endocytic trafficking of activated EGFR is AP-2 dependent and occurs through preformed clathrin spots
Joshua Z. Rappoport and Sanford M. Simon
Accepted 16 January 2009 Journal of Cell Science 122, 1301-1305
Exocytosis of Post-Golgi Vesicles Is Regulated by Components of the Endocytic Machinery
Jyoti K. Jaiswal, Victor M. Rivera, and Sanford M. Simon
DOI 10.1016/j.cell.2009.04.064
Determinism and divergence of apoptosis susceptibility in mammalian cells
Patrick D. Bhola and Sanford M. Simon
Accepted 15 September 2009 Journal of Cell Science 122, 4296-4302
Dynamics of Dynamin during Clathrin Mediated Endocytosis in PC12 Cells
Joshua Z. Rappoport, Katherine P. Heyman, Shahrnaz Kemal, Sanford M. Simon
June 2008 | Volume 3 | Issue 6 | e2416
Imaging the biogenesis of individual HIV-1 virions in live cells
Nolwenn Jouvenet, Paul D. Bieniasz & Sanford M. Simon
Vol 454| 10 July 2008| doi:10.1038/nature06998
A Functional GFP Fusion for Imaging Clathrin-Mediated Endocytosis
Joshua Z. Rappoport and Sanford M. Simon
Traffic 2008; 9: 1250–1255
The conserved isoleucine-valine-phenylalanine motif couples activation state and endocytic functions of beta-arrestins
Anne Burtey, Eva M. Schmid, Marijn G. J. Ford, Joshua Z. Rappoport, Mark G. H. Scott, Stefano Marullo, Sanford M. Simon, Harvey T. McMahon and Alexandre Benmerah
Traffic 2007; 8: 914–931
Patients with a non-dysferlin Miyoshi myopathy have a novel membrane repair defect
Jyoti K. Jaiswal1, Gareth Marlow, Gillian Summerill, Ibrahim Mahjneh, Sebastian Mueller, Maria Hill, Katsuya Miyake, Hannelore Haase, Louise V. B. Anderson, Isabelle Richard, Sari Kiuru-Enari, Paul L. McNeil, Sanford M. Simon and Rumaisa Bashir
Traffic 2007; 8: 77–88
Dynamic Interaction of HIV-1 Nef with the Clathrin-Mediated Endocytic Pathway at the Plasma Membrane
Anne Burtey, Joshua Z. Rappoport, Jerome Bouchet, Stephane Basmaciogullari, John Guatelli, Sanford M. Simon, Serge Benichou, and Alexandre Benmerah
Traffic 2007; 8: 61–76
Imaging single events at the cell membrane
Jyoti K Jaiswal & Sanford M Simon
VOLUME 3 NUMBER 2 FEBRUARY 2007 NATURE CHEMICAL BIOLOGY
Resolving vesicle fusion from lysis to monitor calcium-triggered lysosomal exocytosis in astrocytes
Jyoti K. Jaiswal, Marina Fix, Takahiro Takano, Maiken Nedergaard, and Sanford M. Simon
PNAS August 28, 2007 vol. 104 no. 35 14151–14156
Studying Individual Events in Biology
Stefan Wennmalm and Sanford M. Simon
Annu. Rev. Biochem. 2007. 76:419–46
Dynamics of clathrin and adaptor proteins during endocytosis
Joshua Z. Rappoport, Shahrnaz Kemal, Alexandre Benmerah and Sanford M. Simon
Am J Physiol Cell Physiol 291:C1072-C1081, 2006.
Plasma Membrane Is the Site of Productive HIV-1 Particle Assembly
Nolwenn Jouvenet, Stuart J. D. Neil, Cameron Bess, Marc C. Johnson, Cesar A. Virgen, Sanford M. Simon, Paul D. Bieniasz
December 2006 | Volume 4 | Issue 12 | e435 PLOS BIOL
Receptor-mediated glutamate release from volume sensitive channels in astrocytes
Takahiro Takano, Jian Kang, Jyoti K. Jaiswal, Sanford M. Simon, Jane H.-C. Lin, Yufei Yu, Yuxing Li, Jay Yang, Gerald Dienel, H. Ronald Zielke, and Maiken Nedergaard
16466–16471 PNAS November 8, 2005 vol. 102 no. 45
Synthesis of compact multidentate ligands to prepare stable hydrophilic quantum dot fluorophores
H. Tetsuo Uyeda, Igor L. Medintz, Jyoti K. Jaiswal, Sanford M. Simon, and Hedi Mattoussi
J. AM. CHEM. SOC. 2005, 127, 3870-3878
Analysis of the AP-2 adaptor complex and cargo during clathrin-mediated endocytosis
Joshua Z. Rappoport, Alexandre Benmerah, and Sanford M. Simon,
Traffic. 2005 July ; 6(7): 539–547.
Potentials and pitfalls of fluorescent quantum dots for biological imaging
Jyoti K. Jaiswal and Sanford M. Simon
TRENDS in Cell Biology Vol.14 No.9 September 2004
Tracking metastatic tumor cell extravasation with quantum dot nanocrystals and fluorescence emission-scanning microscopy
Evelyn B Voura, Jyoti K Jaiswal, Hedi Mattoussi & Sanford M Simon
NATURE MEDICINE VOLUME 10 | NUMBER 9 | SEPTEMBER 2004
Use of quantum dots for live cell imaging
Jyoti K Jaiswal, Ellen R Goldman, Hedi Mattoussi & Sanford M Simon
NATURE METHODS | VOL.1 NO.1 | OCTOBER 2004
Understanding living clathrin-coated pits
Joshua Z. Rappoport, Sanford M. Simon and Alexandre Benmerah
Traffic 2004; 5: 327–337
Imaging single membrane fusion events mediated by SNARE proteins
Marina Fix, Thomas J. Melia, Jyoti K. Jaiswal, Joshua Z. Rappoport, Daoqi You, Thomas H. Sollner, James E. Rothman, and Sanford M. Simon
PNAS May 11, 2004 vol. 101 no. 19 7311–7316
Signal sequence cleavage of peptidyl-tRNA prior to release from the ribosome and translocon
Michael S. Wollenberg and Sanford M. Simon
THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 279, No. 24, Issue of June 11, pp. 24919–24922, 2004
Synaptotagmin VII restricts fusion pore expansion during lysosomal exocytosis
Jyoti K. Jaiswal, Sabyasachi Chakrabarti, Norma W. Andrews, Sanford M. Simon
August 2004 | Volume 2 | Issue 8 | e233
Migrating fibroblasts perform polarized microtubule-dependent exocytosis towards the leading edge
Jan Schmoranzer, Geri Kreitzer and Sanford M. Simon
Journal of Cell Science 116, 4513-4519 2003
The AP-2 complex is excluded from the dynamic population of plasma membrane-associated clathrin
Joshua Z. Rappoport, Bushra W. Taha, Simone Lemeer, Alexandre Benmerah, and Sanford M. Simon
THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 278, No. 48, Issue of November 28, pp. 47357–47360, 2003
Co-translational Targeting and Translocation of the Amino Terminus of Opsin across the Endoplasmic Membrane Requires GTP but Not ATP
Elliott M. Kanner, Martin Friedlander, and Sanford M. Simon
THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 278, No. 10, Issue of March 7, pp. 7920–7926, 2003
Movement of plasma-membrane-associated clathrin spots along the microtubule cytoskeleton
Joshua Z. Rappoport, Bushra W. Taha and Sanford M. Simon
Traffic 2003; 4: 460–467
Long-term multiple color imaging of live cells using quantum dot bioconjugates
Jyoti K. Jaiswal, Hedi Mattoussi, J. Matthew Mauro, and Sanford M. Simon
JANUARY 2003 • VOLUME 21 • nature biotechnology
Three-dimensional analysis of post-Golgi carrier exocytosis in epithelial cells
Geri Kreitzer, Jan Schmoranzer, Seng Hui Low, Xin Li, Yunbo Gan, Thomas Weimbs, Sanford M Simon and Enrique Rodriguez-Boulan
NAT CELL BIOL 27 January 2003; DOI: 10.1038/ncb917
Subcellular localization and activity of multidrug resistance proteins
Asha Rajagopal and Sanford M. Simon
Molecular Biology of the Cell Vol. 14, 3389–3399, August 2003
Role of microtubules in fusion of post-Golgi vesicles to the plasma membrane
Jan Schmoranzer and Sanford M. Simon
Molecular Biology of the Cell Vol. 14, 1558–1569, April 2003
Glycosylation affects the rate of traffic of the shaker potassium channel through the secretory pathway
Natalie F. de Souza and Sanford M. Simon
Biochemistry 2002, 41, 11351-11361
Real-time analysis of clathrin-mediated endocytosis during cell migration
Joshua Z. Rappoport and Sanford M. Simon
Accepted 22 November 2002 Journal of Cell Science 116, 847-855
Membrane proximal lysosomes are the major vesicles responsible for calcium-dependent exocytosis in nonsecretory cells
Jyoti K. Jaiswal, Norma W. Andrews, and Sanford M. Simon
The Journal of Cell Biology, Volume 159, Number 4, November 25, 2002 625–635
The amino terminus of opsin translocates 'posttranslationally' as efficiently as cotranslationally
Elliott M. Kanner, Irene K. Klein, Martin Friedlander, and Sanford M. Simon
Biochemistry 2002, 41, 7707-7715
Post-golgi carrier exocytosis in epithelial cells
Geri Kreitzer, Jan Schmoranzer, Seng Hui Low, Xin Li, Yunbo Gan, Thomas Weimbs, Sanford M Simon and Enrique Rodriguez-Boulan
NATURE CELL BIOL 126 OGY VOL 5 FEBRUARY 2003
In vivo analysis of human multidrug resistance protein 1 (MRP1) activity using transient expression of fluorescently tagged MRP1
Asha Rajagopal, Alok C. Pant, Sanford M. Simon, and Yu Chen
CANCER RESEARCH 62, 391–396, January 15, 2002
Insulin-regulated release from the endosomal recycling compartment is regulated by budding of specialized vesicles
Michael A. Lampson, Jan Schmoranzer, Anja Zeigerer, Sanford M. Simon, and Timothy E. McGraw
Molecular Biology of the Cell Vol. 12, 3489–3501, November 2001
P-glycoprotein does not reduce substrate concentration from the extracellular leaflet of the plasma membrane in living cells
Yu Chen, Alok C. Pant, and Sanford M. Simon
CANCER RESEARCH 61, 7763–7769, November 1, 2001
Assembling filamentous phage occlude pIV channels
Denise K. Marciano, Marjorie Russel, and Sanford M. Simon
PNAS u July 31, 2001 u vol. 98 u no. 16 u 9359–9364
Staphylococcus aureus RN6390 replicates and induces apoptosis in a pulmonary epithelial cell line
BARBARA C. KAHL, MARK GOULIAN, WILLEM VAN WAMEL, MATHIAS HERRMANN, SANFORD M. SIMON, GILLA KAPLAN, GEORG PETERS, AND AMBROSE L. CHEUNG
INFECTION AND IMMUNITY, Sept. 2000, p. 5385–5392
Tracking single proteins within cells
Mark Goulian and Sanford M. Simon
Biophysical Journal Volume 79 October 2000 2188–2198
In situ biochemical demonstration that P-glycoprotein is a drug efflux pump with broad specificity
Yu Chen and Sanford M. Simon
The Journal of Cell Biology, Volume 148, Number 5, March 6, 2000 863–870
Imaging constitutive exocytosis with total internal reflection fluorescence microscopy
Jan Schmoranzer, Mark Goulian, Dan Axelrod, and Sanford M. Simon
The Journal of Cell Biology, Volume 149, Number 1, April 3, 2000 23–31
An aqueous channel for filamentous phage export
Denise K. Marciano, Marjorie Russel, Sanford M. Simon
28 MAY 1999 VOL 284 SCIENCE
A mechanism for tamoxifen-mediated inhibition of acidification
Yu Chen, Melvin Schindler, and Sanford M. Simon
THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 274, No. 26, Issue of June 25, pp. 18364–18373, 1999
Tamoxifen inhibits acidification in cells independent of the estrogen receptor
NIHAL ALTAN, YU CHEN, MELVIN SCHINDLER, AND SANFORD M. SIMON
Proc. Natl. Acad. Sci. USA Vol. 96, pp. 4432–4437, April 1999
Defective acidification in human breast tumor cells and implications for chemotherapy
Nihal Altan, Yu Chen, Melvin Schindler, and Sanford M. Simon
J. Exp. Med Volume 187, Number 10, May 18, 1998 1583–1598
Cellular probes on the move
Sanford M. Simon
1996 - Nat. Biotechnol Vol 14
Biogenesis of polytopic membrane proteins- Membrane segments assemble within translocation channels prior to membrane integration
Angela C. Borel and Sanford M. Simon
Cell, Vol. 85, 379–389, May 3, 1996
Defective pH regulation of acidic compartments in human breast cancer cells (MCF-7) is normalized in adriamycin-resistant cells (MCF-7adr)
Melvin Schindler, Sharon Grabski, Ed Hoff, and Sanford M. Simon
Biochemistry, Vol. 35, No. 9, 1996
Biogenesis of polytopic membrane proteins- Membrane segments of p-glycoprotein sequentially translocate to span the ER membrane
Angela C. Borel and Sanford M. Simon
Biochemistry, Vol. 35, No. 33, 1996
Protein-conducting channels for the translocation of proteins into and across membranes
Sanford M. Simon
Cold Spring Harbor Symposia on Quantitative Biology, Volume LX. 1995
Enter the 'swinging gate'
Sanford M. Simon
NATURE VOL 371 8 September 1994
Intracellular pH and the control of multidrug resistance
SANFORD SIMON, DEBORSHI RoY, AND MELVIN SCHINDLER
Proc. Nati. Acad. Sci. USA Vol. 91, pp. 1128-1132, February 1994
Cell biological mechanisms of multidrug resistance in tumors
Sanford M. Simon and Melvin Schindler
Proc. Nati. Acad. Sci. USA Vol. 91, pp. 3497-3504, April 1994
What drives the translocation of proteins
SANFORD M. SIMON, CHARLES S. PESKIN, AND GEORGE F. OSTER
Proc. Nati. Acad. Sci. USA Vol. 89, pp. 3770-3774, May 1992
Myristoylation of proteins in the yeast secretory pathway
Sanford M. Simon and Alan Aderem
THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 267, No. 6, Issue of February 25, pp. 3922-3931, 1992
Signal peptides open protein-conducting channels in Escherichia coli
Sanford M. Simon and Gunter Blobel
Cell, Vol. 69, 677-664, May 15, 1992
A protein-conducting channel in the endoplasmic reticulum
Sanford M. Simon and Gunter Blobel
Cell, Vol. 65, 371-360, May 3, 1991
Large aqueous channels in membrane vesicles derived from the rough endoplasmic reticulum of canine pancreas or the plasma membrane of Escherichia coli
SANFORD M. SIMON, GUNTER BLOBEL, AND JOSHUA ZIMMERBERG
Proc. Nati. Acad. Sci. USA Vol. 86, pp. 6176-6180, August 1989 Cell Biology
Compartmentalization of the submembrane calcium activity during calcium influx and its significance in transmitter release
SANFORD M. SIMON AND RODOLFO R. LLINAS
BIOPHYS. J. Volume 48 September 1985 485-498
Transmission by presynaptic spike-like depolarization in the squid giant synapse
R. LLINAS, M. SUGIMORI, AND S. M. SIMON
Proc. Nati Acad. Sci. USA Vol. 79, pp. 2415-2419, April 1982 Neurobiology
A quantitative rotational model for studying serotonergic function in the rat
BARRY L. JACOBS, SANFORD M. SIMON, DANIEL D. RUIMY and MICHAEL E.TRULSON
Brain Research, 124 (1977) 271-281
