Karol Fiedorczuk, Ph.D.
Karol received his MS degree in Biotechnology from the University of Maria Curie-Sklodowska in Poland. His studies investigated interactions in the glioma microenvironment, conducted at the Nencki Institute of Experimental Biology in Warsaw. Later he spent one and a half years learning X-ray crystallography and cryo-EM techniques in the labs of Matthias Wilmanns (EMBL-Hamburg) and Venki Ramakrishnan (MRC-LMB). After that he pursued his PhD at MRC-MBU and IST Austria under the supervision of Leonid Sazanov. He defended his PhD thesis, "Cryo-EM studies of mammalian mitochondrial complex I," at the University of Cambridge, UK, in the summer of 2017, and joined the Chen Lab in November 2017.
Zachary Johnson, Ph.D.
Zach received his BS in Chemistry from the University of Florida in 2009. He completed his doctoral work in Biochemistry at Duke University in 2015 under the guidance of Seok-Yong Lee. During his time at Duke, he studied the structure and function of concentrative nucleoside transporters (CNTs), elucidating the first three-dimensional structure of a member of the CNT family and examining the molecular origins of nucleoside and drug selectivity of CNTs. Following the completion of his graduate work, he joined the Chen lab in 2015.
Vincent received a B.S. in Biology at Massachusetts Institute of Technology in 2015. He joined the Chen lab in 2016.
Youngjin Kim, Ph.D.
Youngjin received a BS degree in chemistry from Sungkyunkwan University in South Korea in 2003. From 2003 to 2014, she carried out her M.S., Ph.D., and postdoctoral studies at the Korea Advanced Institute of Science and Technology (KAIST), where she was advised by Dr. Jie-oh Lee. During the course of her Ph.D. program and postdoctoral work, she focused on structural studies of immune receptors and determined the structures of the CD40-CD154 complex and Lipolysaccharide Binding Protein (LBP). In 2014, she joined the Chen lab to study ABC transporters.
Fangyu received her B.S. in Immunology from McGill University, Canada in 2015.
Sarah McCarry is a writer and editor. She joined the Chen Lab in 2014.
Lwin Kyaw Myo, Ph.D.
Lwin received his bachelor degree (1st Hons) in 2008 from University of Bradford (UK) in Singapore. After graduation, Lwin joined the Oi Lian Kon lab at the National Cancer Center Singapore (NCCS). Leong Siew Hong (a PhD student) and Lwin characterized recurrent chromosomal breakpoints in primary gastric tumors. From 2012 to 2017, Lwin pursued his doctoral dissertation on "Kinesin-related Smy1 involvement in Myo2-dependent secretory vesicle transport" in budding yeast under the supervision of Prof. Anthony Bretscher at Cornell University. Lwin also discovered a new Rho GAP protein that has a positive regulatory role in Myo2-dependent vesicle transport. He named the protein, GYM1 (GAP with Yeast Myo2). He joined the Chen lab in 2017.
Michael Oldham, Ph.D.
Senior Research Associate
Michael received his Bachelors degrees in Biochemistry (BS) and Biology (BA) at Indiana University. He pursued his Ph.D. from Vanderbilt University under the guidance of Dr. Marcia Newcomer, where he studied the structure and function of eicosanoid biosynthesis in soft coral. As a postdoc in the Chen Lab at Purdue, he determined the structure of the E. coli maltose transporter in several conformational states. At Rockefeller University, Michael plans to focus his study on eukaryotic ABC transporters.
Ben received his B.S. in Biochemistry from Tufts University (2018), where he also completed a minor in Studio Art. At Tufts, he worked in the Kritzer Lab designing cyclic peptide inhibitors of the Eps15 - stonin2 interaction. He joined the Chen Lab in 2018 as a Research Assistant.
Ana-Maria received her B.S. in Medical Lab Science and Masters in Biology with Specialization in Biotechnology from Hunter College. She has previously done research in the Laboratory of Bacterial Pathogenesis and Immunology (Fischetti Lab) at Rockefeller University while she was an undergraduate student at Hunter College. There, under the close mentorship of Dr. Assaf Raz, she studied the bacteria which causes strep throat called Streptococcus pyogenes and performed a series of experiments in which inhibition of sortase by small-molecule inhibitors lead to rapid elimination of the bacterium. These inhibitors are possible anti-bacterial agents since they work by preventing the anchoring of virulence factors to the cell wall of the bacterium and reduce the pathogenicity of S. pyogenes. She joined the Chen Lab as a Research Assistant in 2016. Ana-Maria is currently the Lab Coordinator and Cell Culture guru.
Zhe Zhang, Ph.D.
Zhe received a B.S. in Biotechnology from Shandong University, China in 2008. In 2015, he received a Ph.D. degree in Biochemistry and Molecular Biology from the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences. His Ph.D. studies focused on the endocytosis process, specifically structural and functional studies of the Rab GTPases in complex with their GEF and effector proteins. He showed the molecular mechanism for the regulation of the Rabex-5 GEF activity and the binding specificity of Rab9A with RUTBC2. He joined the Chen lab in 2015.
Hongtu Zhao, Ph.D.
Hongtu received a B.S. in Biology from Lanzhou University, China in 2010. He did his graduate work at the Institute of Biophysics, Chinese Academy of Sciences, and received a Ph.D. degree in Biochemistry and Molecular Biology. His doctoral work focused on structural studies of the Cascade complex in the CRISPR-Cas immune system and provided a detailed explanation for Cascade assembly and target DNA recognition. He joined the Chen lab in 2016.