Astrotactin Provides A Neuron-Glial Ligand For Movement Along The Glial Fiber
To provide an assay for cell surface receptor systems that function in neuronal migration, low power views are used to track the movement of a large population of cerebellar granule cells. In the first sequence, neurons are seen migrating along glial fibers. The addition of antibodies against the neuronal protein astrotactin (ASTN1) (flash across the top of the screen) results in rapid arrest of neuronal movement. As migration ceases, the long glial processes "sway" across the field. From Fishell G, Hatten, ME. 1991. Astrotactin provides a receptor system for CNS neuronal migration. Development 113:755-65.
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