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Laboratory of Biochemical Genetics and Metabolism

Atherosclerotic disease, the hardening of the arteries that underlies coronary heart disease, stroke and peripheral vascular disease, is responsible for about 40 percent of the deaths in the United States each year. It is a complex genetic disease involving multiple genes and important gene-environment interactions. Dr. Breslow's laboratory explores the genetic basis of atherosclerosis, working to determine what makes certain individuals more or less susceptible to this disease, and pioneers novel therapies to fight it.