Selected Publications (2000-present)

  1. Strahl, B.D. and Allis, C.D. (2000) The language of covalent histone modifications. Nature 403, 41-45
  2. Cheung, P., Allis, C.D. and Sassone-Corsi, P. (2000) Signaling to chromatin through histone modifications. Cell 103, 263-271
  3. Jenuwein, T. and Allis, C.D. (2001) Translating the histone code. Science 293, 1074-1080
  4. Sun, Z.-W. and Allis, C.D. (2002) Ubiquitylation of histone H2B regulates H3 methylation and gene silencing in yeast. Nature 418, 104-108
  5. Briggs, S.D., Xiao, T., Sun, Z.-W., Caldwell, J.A., Shabanowitz, J., Hunt, D.F., Strahl, B.D. and Allis, C.D. (2002) Gene silencing: trans-histone regulatory pathway in chromatin. Nature 418, 498
  6. Fischle, W., Wang, Y. and Allis, C.D. (2003) Binary switches and modification cassettes in histone biology and beyond. Nature 425, 475-479
  7. Cheung, W.L., Ajiro, K., Kloc, M., Cheung P., Mizzen, C.A., Beeser, A., Etkin, L.D., Chernoff, J. and Allis, C.D. (2003) Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. Cell 16, 507-517 (featured article)
  8. Fischle, W., Tseng, B.S., Dormann, H., Ueberheide, B.M., Garcia, B.A., Shabanowitz, J., Hunt, D.F., Funabiki, H. and Allis, C.D. (2005) Regulation of HP1-chromatin binding by histone H3 methylation and phosphorylation. Nature 438, 1116-1122
  9. Ahn, S.-H., Cheung, W.L., Hsu, J.-Y., Smith, M.M. and Allis, C.D. (2005) Sterile 20 kinase phosphorylates histone H2B at serine10 during hydrogen peroxide-induced apoptosis in S. cerevisiae. Cell 120, 25-36
  10. Ahn, S., Diaz, R.L., Grunstein, M., Allis, C.D. (2006) Histone H2B deacetylation at lysine 11 is required for yeast apoptosis induced by phosphorylation of H2B at serine 10. H2B. Mol. Cell 24, 211-220
  11. Wysocka, J., Swigut, T., Xiao, H., Landry, J., Kauer, M., Tackett, A., Chait, B., Brivanlou, A.H., Wu, C. and Allis, C.D. (2006) A PHD finger in the largest subunit of NURF couples histone H3 K4 trimethylation with chromatin remodeling. Nature 442, 86-90
  12. Taverna, S.D., Ilin, S., Rogers, R.S., Tanny, J.C., Lavender, H., Li, H., Baker, L., Boyle, J., Blair, L.P., Chait, B.T., Patel, D.J., Aitchison, J.D., Tackett, A.J. and Allis, C.D. (2006) Yng1 PHD finger binding to histone H3 trimethylated at lysine 4 targets lysine 14 specific NuA3 HAT activity to a subset of promoters for transcriptional activation. Mol. Cell 24, 1-12
  13. Ruthenburg, A., Allis, C.D., Wysocka, J. (2007) Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark. Mol. Cell. 25, 15-37.
  14. Ruthenburg, A.J., Li, H., Patel, D.J., Allis, C.D. (2007) Multivalent engagement of chromatin modifications by linked binding modules. Nat Rev Mol Cell Biol, 12: 983-994
  15. Taverna, S.D., Li, H., Ruthenburg, A.J., Allis, C.D., Patel, D.J. (2007) How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers. Nat Struct Mol Biol, 14: 1025-1040 
  16. Goldberg, A.D., Allis, C.D., Bernstein, E. (2007) Epigenetics: a landscape takes shape. Cell 128, 635-638
  17. Wang, G.G., Allis, C.D., Chi, P. (2007) Chromatin remodeling and cancer: part II - ATP-dependent chromatin remodeling. Trends in Molecular Medicine 13, 373-380
  18. Baker, L.A., Allis, C.D. and Wang, G.G. (2008) PHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks. Mutat. Res. 647, 3-12
  19. Duncan, E.M., Muratore-Shroeder, T.L., Cook, R.G., Shabanowitz, J., Hunt, D.F., Allis, C.D. (2008) Cathepsin L proteolytically processes histone H3 during mouse embryonic stem cell differentiation. Cell 135, 284-294
  20. Borrelli, E., Nestler, E. Allis, C.D., Sassone-Corsi, P. (2008) Decoding the epigenetic language of neuronal plasticity. Neuron 60, 961-974
  21. Xiao, A., Li, H., Shechter, D., Ahn, S.H., Fabrizio, L.A., Erdjument-Bromage, H., Murakami-Ishibe, S., Wang, B., Tempst, P., Hofmann, K., Patel, D.J., Elledge, S.J., Allis, C.D. (2009) WSTF regulates the DNA damage response of H2A.X via a novel tyrosine kinase activity. Nature 457, 57-62
  22. Wang, G.W., Song, J., Wang, Z., Dormann, H., Casadio, F., Li, H., Patel, D. and Allis, C.D. (2009) Engaging histone H3 Lys4 methylation marks by aberrant PHD fingers perturbs cellular identities and initiates tumorigenesis. (2009) Nature 459, 847-851   
  23. Goldberg A.D., Banaszynski L.A., Noh K.M., Lewis P.W., Elsässer S.J.,Stadler S., Dewell S., Law M., Guo X., Li X., Wen D., Chapgier A., DeKelver, R.C., Miller J.C., Lee Y.L., Boydston E.A., Holmes M.C., Gregory P.D., Greally J.M., Rafii S., Yang C., Scambler P.J., Garrick D., Gibbons R.J., Higgs D.R.,Cristea I.M., Urnov F.D., Zheng D., Allis C.D. (2010) Distinct factors controlhistone variant H3.3 localization at specific genomic regions. Cell 140, 678-691 
  24. Allis, C.D. and Muir, T.W. (2011) Spreading chromatin into chemical biology. ChemBioChem. 12, 264-279
  25. Elsässer, S.J., Huang, H., Lewis, P.W., Allis, C.D. and Patel, D.J. (2012) DAXX envelops a histone H3.3-H4 dimer for H3.3 specific recognition.  Nature 491, 560-565
  26.  Kim, J., Kim, J.A., McGinty, R.K., Nguyen, U.T.T., Muir, T.W., Allis, C.D. and Roeder,R.G. (2013) The n-SET domain of Set1 regulates H2B ubiquitylation-dependent H3K4 methylation. Mol. Cell, February 26 (Epub ahead of print)
  27. Lewis, P.W., Mueller, M.M., Koletsky, M.S., Cordero, F., Lin, S., Banaszynski, L.A.,Garcia, B.A., Muir, T.W., Becher, O.J. and Allis C.D. (2013) Inhibition of PRC2 activity by gain-of-function mutations in pediatric glioblastoma. Science, Mar 28. (Epub ahead of print)
  28. Nacev, B.A., Feng, L., Lemiesz, A.E., Bagert, J.D., Muir, T.W. and Allis, C.D. (2019) The expanding landscape of ‘oncohistone’ mutations in human cancers. Nature 567, 473-478
  29. Weinberg, D.N., Papillion-Cavanagh, S., Chen, H., Chen, X., Rajagopalan, K.N., Horth, C., Yue, Y., Nikbakht, H., Lemiesz, A.E., Marchione, D.M., Bareke, E., Djedid, A., Harutyunyan, A.S., Jadado, N., Garcia, B.A., Li, H., Allis, C.D., Majewski, J., and Lu, C. (2019) H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape. Nature 573, 281-286
  30. Wan, L., Chong S., Liang, A., Xuan, F., Cui, X., Gates, L., Carrol, T.S., Li, Y., Chen, G., Wang, S.P., Ortiz, M.V., Daley, S., Feng, L., Wang, X., Kentsis, A., Muir, T.W., Roeder, R.G., Li, H., Li, W., Tijan, R., Wen, H., and C.D. Allis (2020) Impaired cell fate through gain-of-function mutations in a chromatin reader. Nature 577, 121-126
  31. Armache, A., Yang, S., Robbins, L., Durmaz, C., Daman, A., Gyu-Cheung, J., Martinez de Paz, A., Ravishankar, A., Radic, T., Lin, S., Garcia, B.A., Hake, S., Li, H., Allis, C.D., and Josefowicz, S.Z. (2020) Variant-specific phosphorylation of the ancestral histone H3.3 amplifies stimulation-induced transcription. Nature, 583 852–857

    Textbooks

    Allis, C.D., Jenuwein, T., Reinberg, D. (eds.), Caparros, M.L. (assoc. ed.) Epigenetics Cold Spring Harbor Laboratory Press. Cold Spring Harbor, NY, 2006

Strahl, B.D. and Allis, C.D. (2000) The language of covalent histone modifications. Nature 403, 41-45Cheung, P., Allis, C.D. and Sassone-Corsi, P. (2000) Signaling to chromatin through histone mod