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Selected Publications

For a full list of Steller Lab Publications please see the Rockefeller University Library database

Hermann Steller, Ph.D.

Sandu, C., Chandramouli, N., Glickman, F.J., Molina, H., Kuo, C.L., Kukushkin, N., Goldberg, A.L., and Steller, H. (2015). Thiostrepton interacts covalently with Rpt subunits of the 19S proteasome and proteasome substrates. J. Cell. Mol. Medicine May 30. doi: 10.1111/jcmm.12602.

Fuchs, Y., and Steller, H. (2015). Live to die another way: modes of programmed cell death and the signals emanating from dying cells. Nat. Rev. Cell Mol. Biology 16, 329-344.

Liu K, Ding L, Li Y, Yang H, Zhao C, Lei Y, Han S, Tao W, Miao D, Steller H, Welsh MJ, and Liu L (2014). Neuronal necrosis is regulated by a conserved chromatin-modifying cascade. Proc Natl Acad Sci U S A 111(38):13960-5.

Sandu C, Ngounou Wetie AG, Darie CC, and Steller H. (2014). Thiostrepton, a natural compound that triggers heat shock response and apoptosis in human cancer cells: a proteomics investigation. Adv Exp Med Biol. 806:443-5.

Perez-Garijo, A., and Steller, H. (2014). The benefits of aging: cellular senescence in normal development. EMBO J. 33, 99-100.

Guarner, A., Manjón, C., Edwards, K., Steller, H., Suzanne, M., and Sánchez-Herrero, E. (2014). The zinc finger homeodomain-2 gene of Drosophila controls notch targets and regulates apoptosis in the tarsal segments. Developmental Biology 385, 350-65. doi: 10.1016/j.ydbio.2013.10.011. Epub 2013 Oct 19.

Perez-Garijo, A., Fuchs, F., and Steller, H. (2013). Apoptotic cells can induce non-autonomous apoptosis through the TNF pathway. eLife 2:e01004.

Fuchs, Y., Brown, S., Gorenc, T., Rodriguez, J., Fuchs, E., and Steller, H. (2013). Sept4/ARTS regulates stem-cell cell apoptosis and skin regeneration. Science 341, 286-289.

Cho-Park, P., and Steller, H. (2013). Proteasome regulation by ADP-ribosylation. Cell, 153, 614–627.

Maor, G., Rencus-Lazar, S., Filocamo, M., Steller, H., Segal, D., and Horowitz, M. (2013). Unfolded protein response in Gaucher disease: from human to Drosophila. Orphanet Journal of Rare Diseases 8, 140.

Suzanne, M., Steller, H. (2013). Shaping organisms with apoptosis. Cell Death & Differentiation, 20, 669-675.

Mollereau, B., Perez-Garijo, A., Bergmann, A., Miura, M., Gerlitz, O., Ryoo, H.D., Steller, H. and Morata, G. (2013). Compensatory proliferation and apoptosis-induced proliferation: a need for clarification. Cell Death & Differentiation. 20, 181.

Fuchs, Y., and Steller, H. (2011). Programmed cell death in animal development. Cell 147, 742-58.

Gafuik, C., and Steller, H. (2011). A gain-of-function germline mutation in Drosophila ras1 affects apoptosis and cell fate during development. Plos One. 6(8): e23535.

Fuchs, Y., Brown, B., Gorenc, T., Rodriguez, J., Fuchs, E., and Steller, H. (2013). Sept4/ARTS Regulates Stem Cell Apoptosis and Skin Regeneration. Science –in press.

Fuchs, Y., and Steller, H. (2011). Programmed cell death in animal development. Cell 147, 742-58.

Bader, M., Benjamin, S., Wapinski, O., David M. Smith, D.M., Goldberg, A.L., and Steller, H. (2011). A conserved F-box-regulatory complex controls proteasome activity in Drosophila. Cell, 145, 1-12.

Gambis A, Dourlen P., Steller H., and Mollerau B. (2011). Two-color in vivo imaging of photoreceptor apoptosis and development in Drosophila. Development Biology. 351, 128-34.

Benjamin S., and Steller H. (2010). Another Tier for Caspase Regulation: IAPs as NEDD8 E3 Ligases. Development Cell. 19, 791-2.

Bergmann A, Steller H. (2010). Apoptosis, Stem Cells, and Tissue Regeneration. Science Signaling. 3, 145.

Garcia-Fernandez M, Kissel H, Brown S, Gorenc T, Shile AJ, Rafii S, Larisch S, and Steller H. (2010). Sept4/ARTS is required for stem cell apoptosis and tumor suppression. Genes Dev. 24, 2282-93.

Sandu, C., Ryoo, H.D., and Steller, H. (2010). Drosophila IAP antagonists form multimeric complexes to promote cell death. J Cell Biol. 190(6): 1039-52.

Suzanne M, Petzoldt AG, Speder P, Coutelis JB, Steller H, Noselli S. (2010). Coupling of Apoptosis and L/R Patterning Controls Stepwise Organ Looping. Current Biology 20, 1773-1776.

Bader, M., Arama, E., and Steller, H. (2010). A novel F-box protein is required for caspase activation during Drosophila sperm differentiation. Development. 137, 1679-1688.

Fan, Y., Lee, T.V., Xu, D., Chen, Z., Lamblin, A.F., Steller, H., and Bergmann, A. (2009). Dual roles of Drosophila p53 in cell death and cell differentiation. Cell Death Diff. 10, 1038.

Bader, M., and Steller, H. (2009). Regulation of cell death by the ubiquitin-proteasome system. Current Opinion Cell Biol. 21, 1-7.

Suzanne, M. and Steller, H. (2009). Letting Go: Modification of Cell Adhesion during Apoptosis. J. Biology 8, 49.1-49.4.

Mendes, C., Levet, C., Chatelain, G., Dourlen, P., Fouillet, A., Dichtel-Danjoy, M., Gambis, A., Ryoo, H.D., Steller, H., and Mollereau, B. (2009). ER stress protects from retinal degeneration. EMBO J. Apr 2. [Epub ahead of print].

Betz A., Ryoo H.D., Steller H., and Darnell, J.E. (2008). STAT92E is a positive regulator of Drosophila inhibitor of apoptosis 1 (DIAP/1) and protects against radiation-induced apoptosis. Proc Natl Acad Sci U S A 105, 13805-10.

Schile, A.J, García-Fernández, M., and Steller, H. (2008). Regulation of Apoptosis by XIAP Ubiquitin-Ligase Activity. Genes Dev. 22, 2256-66.

Steller, H. (2008). Regulation of apoptosis in Drosophila. Cell Death Diff. 15, 1132-1138.

Arama, E., Bader, M., Gabrielle E. Rieckhof , G.E., and Steller, H. (2007). A Ubiquitin Ligase Complex Regulates Caspase Activation During Sperm Differentiation in Drosophila. PLoS Biol. 11, e251.

Arama, E., Bader, M., Gabrielle E. Rieckhof , G.E., and Steller, H. (2007). A Ubiquitin Ligase Complex Regulates Caspase Activation During Sperm Differentiation in Drosophila. PLoS Biol. 11, e251.

Ryoo, H.D., Domingos, P.M., and Steller, H. (2007). The Unfolded Protein Response is activated as a Protective Mechanism in a Drosophila Model for Autosomal Dominant Retinitis Pigmentosa, EMBO J. 26, 242-52.

Arama, E., Bader, M., Srivastava, M., Bergmann, A., and Steller, H. (2006). The two Drosophila cytochrome C proteins can function in both respiration and caspase activation. EMBO J. 25, 232-243. Abstract PDF

Kissel, H., Hunnicut, G., Georgescu, M., Larisch, S., and Steller, H. (2005). The Sept4 Septin Locus is Required for Sperm Terminal Differentiation in Mice. Developmental Cell 8, 353-364. Abstract PDF

Domingos, P.M., Mloczik, M., Mendes, C.S., Brown, S., Steller, H., and Mollereau, B. (2004). Spalt transcription factors are required for R3/R4 specification and establishment of planar cell polarity in the Drosophila eye. Development 131, 5695-5702. Abstract PDF

Ryoo, H.D., Gorenc, T., and Steller, H. (2004). Apoptotic Cells can induce Compensatory Cell Proliferation through the JNK and the wingless signaling pathways. Developmental Cell 7, 491-501. Abstract PDF

Gottfried, Y., Zivony, Y., Steller, H., and Larisch, S. (2004). The mitochondrial ARTS protein promotes apoptosis through targeting XIAP. EMBO J. 23, 1627-1635. Abstract PDF

Zachariou, A., Tenev, T., Goyal, L., Agapite, J., Steller, H., and Meier, P. (2004). IAP-antagonists exhibit non-redundant modes of action through differential DIAP1 binding. EMBO J. 22, 6642-6652. Abstract PDF

Domingos, P.M., Brown, S., Barrio, R., Ratnakumar, K., Frankfort, B.J., Mardon, G., Steller, H., and Mollereau, B. (2004). Regulation of R7 and R8 differentiation by the spalt genes. Developmental Biology 273, 121-33. Abstract PDF

Arama, E., Agapite, J., and Steller, H. (2003). Caspase Activity and a Specific Cytochrome C are Required for Sperm Differentiation in Drosophila. Developmental Cell 4, 687-697. Abstract PDF

Zhou, L., and Steller, H. (2003). Distinct Pathways Mediate UV-induced Apoptosis in Drosophila Embryos. Developmental Cell 4, 599-605. Abstract PDF

Wilson, R., Goyal, L., Ditzel, M., Zachariou, A., Baker, D.A., Agapite, J., Steller, H., and Meier, P. (2002). The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis. Nature Cell Biology 4, 445-450. Abstract PDF

Ryoo, H.D., Bergmann, A., Gonen, H., Ciechanover, A., and Steller, H. (2002). Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1. Nature Cell Biology 4, 432-438. Abstract PDF

Bergmann, A., Tugentman, M., Shilo, B-Z., and Steller, H. (2002). Regulation of Cell Number by MAPK-Dependent Control of Apoptosis: A Mechanism for Trophic Survial Signaling. Developmental Cell 2, 1-12. Abstract PDF

Jiang, C., Lamblin, A.F., Steller, H., and Thummel, C.S. (2000). A steroid-triggered transcriptional hierarchy controls salivary gland cell death during Drosophila metamorphosis. Molecular Cell 5, 445-455. Abstract PDF

Goyal, L., McCall, K., Agapite, J., Hartwieg, E. and Steller, H. (2000). Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function. EMBO J. 19, 589-597. Abstract PDF

Song, Z., and Steller, H. (1999). Death by Design: Mechanism and Control of Apoptosis. TiBS/TIG/TCB joint millenium issue, M49-M52. Abstract PDF

Zhou, L.,Song, Z., Tittel, J., and Steller, H. (1999). HAC-1, a Drosophila homolog of APAF-1 and CED-4, functions in developmental and radiation-induced apoptosis. Molecular Cell 4, 745-755. Abstract PDF

Haining, N., Newcomb-Carboy, C., Wei, C.-L., and Steller, H. (1999). The Pro-apoptotic Function of Drosophila Hid is Conserved in Mammalian Cells. Proc. Natl. Acad. Sci. USA 96, 4936-4941. Abstract PDF

Bergmann, A., Agapite, J., McCall, K.A., and Steller, H. (1998). The Drosophila hid gene is a direct molecular target of Ras-dependent survival signaling. Cell 95, 331-341. Abstract PDF

Davidson, F.F., and Steller, H. (1998). Blocking Apoptosis Prevents Blindness in Drosophila Retinal Degeneration Mutants. Nature 391, 587-591. Abstract PDF

Song, Z., McCall, K.A., and Steller, H. (1996). DCP-1, a Drosophila Cell Death Protease essential for Development, Science 275, 536-540. Abstract PDF

White, K., Tahaoglu, E., and Steller, H. (1996). Cell killing by Drosophila reaper. Science 271, 805-807. Abstract

Steller, H. (1995). Mechanisms and Genes of Cellular Suicide, Science 267, 1445-1449. Abstract

Grether, M.E., Abrams, J.M., Agapite, J., White, K., and Steller, H. (1995). The head involution defective gene of Drosophila melanogaster functions in Programmed Cell Death, Genes & Development 9, 1694-1708. Abstract

White, K., Grether, M., Abrams, J., Young, L., Farrell, K., and Steller, H. (1994). Genetic Control of Programmed Cell Death in Drosophila. Science 264, 677-683. Abstract

Abrams, J., White, K., Fessler, L., and Steller, H. (1993). Programmed Cell Death During Drosophila Embryogenesis. Development 117, 29-43. Abstract

For a full list of Steller Lab Publications please see the Rockefeller University Library databaseHermann Steller, Ph.D.Sandu, C., Chandramouli, N., Glickman, F.J., Molina, H., Kuo, C.L., Kuk