Leonard Wagner Laboratory of Molecular Genetics and Immunology

 

The lab’s research has made ground-breaking discoveries on the mechanisms by which antibodies mediate anti-tumor responses and/or immune modulation in vivo. Our goal has been to design and conduct research studies that work to resolve the long-standing paradox of how antibodies can mediate and regulate diverse effector activities by defining the distinct Fc receptor pathways they engage. These studies have established the general foundation of antibody-mediated immunotherapy and resulted in the development and approval of novel antibody therapeutics.

The Fc domain of IgG, showing the complex, biantennary glycan linked at Asn 297 In contrast to other glycoproteins, the Fc glycan is a highly ordered structure occupying the groove formed by the A and B chains of the Fc dimer.
Leonard Wagner Laboratory of Molecular Genetics and Immunology
1230 York Avenue
New York, NY 10065
Tel: 212-327-7323
Fax: 212-327-7319
 The lab’s research has made ground-breaking discoveries on the mechanisms by which antibodies mediate anti-tumor responses and/or immune modulation in vivo. Our goal has been to design a