Selected Publications

  1. Wang, W., Whorton, M.R., MacKinnon, R. (2014). Quantitative analysis of mammalian GIRK2 channel regulation by G proteins, the signaling lipid PIP2 and Na+ in a reconstituted system. eLife 2014;3:e03671. DOI: 10.7554/eLife.03671. PubMed PMID#: 25049222.
  2. Brohawn, S.G., Su, Z., MacKinnon, R. (2014). Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K+ channels. PNAS, published ahead of print. PubMED PMID: 24550493; PubMed Central PMCID: 3948252.

  3. Whorton, M.R., MacKinnon, R. (2013). X-ray structure of the mammalian GIRK2-βγ G-protein complex. Nature, published online June 5. PubMED PMID: 23739333.
  4. Banerjee, A., Lee, A., Campbell, E., MacKinnon, R. (2013). Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K+ channel. Elife 2013; e00594. PubMED PMID: 23705070; PubMed Central PMCID: 3360741.
  5. Brohawn, S.G., Campbell, E.B., MacKinnon, R. (2013). Domain-swapped chain connectivity and gated membrane access in a Fab-mediated crystal of the human TRAAK K+ channel. PNAS, 110(6). PubMED PMID: 23341632; PubMed Central PMCID: 358379.
  6. Leonetti, M.D., Yuan, P., Hsiung, Y., MacKinnon, R. (2012). Functional and structural analysis of the human SLO3 pH- and voltage-gated K+ channel. PNAS, 109(47), 19274-279. PubMED PMID: 23129643- in process; PubMed Central PMCID: 3511096.
  7. Feng, L., Campbell, E.B., MacKinnon, R. (2012). Molecular mechanism of proton transport in CLC Cl-/H+ exchange transporters. PNAS, 109(29), 11699-704. PubMed PMID: 22753511; PubMed Central PMCID: 3406864.
  8. Schmidt, D., del Marmol, J., MacKinnon, R. (2012). Mechanistic basis for low threshold mechanosensitivity in voltage-dependent K+ channels. PNAS, 109(26), 10352-7. PubMed PMID: 22675122; PubMed Central PMCID: 3387069.
  9. Brohawn, S.G., del Mármol, J., MacKinnon, R. (2012). Crystal Structure of the Human K2P TRAAK, a Lipid- and Mechano-Sensitive K+ Ion Channel. Science, 335 (6067), 436-441. PubMed PMID: 22282805; PubMed Central PMCID: 367931.
  10. Yuan P., Leonetti M.D., Hsiung, Y., MacKinnon, R. (2011) Open structure of the Ca2+ gating ring in the high-conductance Ca2+-activated K+ channel. Nature, 481 (7379), 94-97PubMed PMID: 22139424; PubMed Central PMCID: 3319005.
  11. Whorton, M.R., MacKinnon, R. (2011). Crystal structure of the mammalian GIRK2 K+ channel and gating regulation by G proteins, PIP(2), and sodium. Cell, 147(1), 199-208. PubMed PMID: 21962516; PubMed Central PMCID: 3243363.
  12. Hansen, S.B., Tao, X., MacKinnon, R. (2011). Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2. Nature, 477(7365), 495-8. PubMed PMID: 21874019; PubMed Central PMCID: 3324908.
  13. Liang, F., Campbell, E.B., Hsiung, Y.C., MacKinnon, R. (2010). Structure of a eukaryotic CLC transporter defines an intermediate state in the transport cycle. Science, 330(6004), 635-41. PubMed PMID: 20929736; PubMed Central PMCID: 3079386.
  14. Butterwick, J.A., MacKinnon, R. (2010). Solution structure and phospholipid interactions of the isolated voltage-sensor domain from KvAP. J Mol Biology, 403(4), 591-606. PubMed PMID: 20851706; PubMed Central PMCID: 2971526.
  15. Yuan, P., Leonetti, M., Pico, A.R., Hsiung, Y.C., MacKinnon, R. (2010). Structure of the human BK channel Ca2+-activation apparatus at 3.0 Å resolution. Science, 329(5988), 182-6. PubMed PMID: 20508092; PubMed Central PMCID: 3022345.
  16. Tao, X., Lee, A., Limapichat, W., Dougherty, D.A., MacKinnon, R. (2010). A gating charge transfer center in voltage sensors. Science, 328(5974), 67-73. PubMed PMID: 20360102; PubMed Central PMCID: 2869078.
  17. Tao, X., Avalos, J.L., Chen, J., MacKinnon, R. (2009). Crystal structure of the eukaryotic strong inward-rectifier K+ channel Kir2.2 at 3.1 Å resolution. Science, 326(5960), 1668-74. PubMed PMID: 20019282; PubMed Central PMCID: 2819303.
  18. Endeward, B., Butterwick, J.A., MacKinnon, R., Prisner, T.F. (2009). Pulsed electron-electron double-resonance determination of spin-label distances and orientations on the tetrameric potassium ion channel KcsA. J Am Chem Soc, 131(42), 15246-50. PubMed PMID: 19919160; PubMed Central PMCID: 2779547.
  19. Schmidt, D., Cross, S.R., MacKinnon, R. (2009). A gating model for the archeal voltage-dependent K+ channel KvAP in DPhPC and POPE: POPG decane lipid bilayers. J Mol Biology, 390(5), 902-12. PubMed PMID: 19481093; PubMed Central PMCID: 2778279.
  20. Lee, S.Y., Letts, J.A., MacKinnon, R. (2009). Functional reconstitution of purified human Hv1 H+ Channels. J Mol Biology, 387(5), 1055-60. PubMed PMID: 19233200; PubMed Central PMCID: 2778278.
  21. Lee, S.Y., Banerjee, A., MacKinnon, R. (2009). Two separate interfaces between the voltage sensor and pore are required for the function of voltage-dependent K+ Channels. PLoS Biology, 7(3), e47. PubMed PMID: 19260762; PubMed Central PMCID: 2650729.
  22. Schmidt, D., MacKinnon, R. (2008). Voltage-dependent K+ channel gating and voltage sensor toxin sensitivity depend on the mechanical state of the lipid membrane. PNAS, 105(49), 19276-19281. PubMed PMID: 19080073; PubMed Central PMCID: 2614752.
  23. Tao, X., MacKinnon, R. (2008). Functional analysis of Kv1.2 and paddle chimera Kv channels in planar lipid bilayers. J Mol Biology, 382(1), 24-33. Epub 2008 Jul 7. PubMed PMID: 18638484; PubMed Central PMCID: 2614752. 
  24. Banerjee, A., MacKinnon, R. (2008). Inferred motions of the S3a helix during voltage-dependent K+ channel gating. J Mol Biology, 381(3), 569-80. Epub 2008 Jun 10. PubMed PMID: 18632115; PubMed Central PMCID: 2819426.
  25. Lee, S.Y., Letts, J.A., MacKinnon, R. (2008). Dimeric subunit stoichiometry of the human voltage-dependent proton channel Hv1. PNAS, 105(22), 7692-7695. PubMed PMID: 18509058; PubMed Central PMCID: 2409406.
  26. Nishida, M., Cadene, M., Chait, B.T., MacKinnon, R. (2007). Crystal structure of a Kir3.1-prokaryotic Kir channel chimera. EMBO J, 26(17), 4005-4015. PubMed PMID: 17703190; PubMed Central PMCID: 1994128.
  27. Long, S.B., Tao X., Campbell, E.B., MacKinnon, R. (2007). Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment. Nature, 450(7168), 376-382. PubMed PMID: 18004376.
  28. Lockless, S.W., Zhou, M., MacKinnon, R. (2007). Structural and thermodynamic properties of selective ion binding in a K+ channel. PLoS Biology, 5(5), e121. PubMed PMID: 17472437; PubMed Central PMCID: 1858713.
  29. Schmidt, D., Jiang, Q.X., MacKinnon, R. (2006). Phospholipids and the origin of cationic gating charges in voltage sensors. Nature, 444(7120), 775-779. PubMed PMID: 17136096.
  30. Valiyaveetil, F.I., Leonetti, M., Muir, T.W., MacKinnon, R. (2006). Ion selectivity in a semisynthetic K+ channel locked in the conductive conformation. Science, 314(5801), 1004-1007. PubMed PMID: 17095703.
  31. Valiyaveetil, F.I., Sekedat, M., MacKinnon, R., Muir, T.W. (2006). Structural and functional consequences of an amide-to-ester substitution in the selectivity filter of a potassium channel. J Am Chem Soc, 128(35), 11591-11599. PubMed PMID: 16939283; PubMed Central PMCID: 2546570.
  32. Lee, S.Y., Lee, A., Chen, J.Y., MacKinnon, R. (2005). Structure of the KvAP voltage-dependent K+ channel and its dependence on the lipid membrane. PNAS, 102(43): 15441-15446. PubMed PMID: 16223877; PubMed Central PMCID: 1253646.
  33. Ruta, V., Chen, J.Y., MacKinnon, R. (2005). Calibrated measurement of gating charge arginine displacement in the KvAP voltage-dependent K+ channel. Cell, 123(3), 463-475. PubMed PMID: 16269337.
  34. Long, S.B., Campbell, E.B., MacKinnon, R. (2005). Voltage sensor of Kv1.2: structural basis of electromechanical coupling. Science, 309(5736), 903-908. PubMed PMID: 16002579.
  35. Long, S.B., Campbell, E.B., MacKinnon R. (2005). Crystal structure of a mammalian voltage-dependent Shaker family K+ channel. Science, 309(5736), 897-903. PubMed PMID: 16002581.
  36. Ohndorf, U.M., MacKinnon, R. (2005). Construction of a cyclic nucleotide-gated KcsA K+ channel. J Mol Biol, 350(5), 857-865. PubMed PMID: 15979092.
  37. Ruta, V., MacKinnon, R. (2004). Localization of the voltage-sensor toxin receptor on KvAP. Biochemistry, 43(31), 10071-10079. PubMed PMID: 15287735.
  38. Valiyaveetil, F.I., Sekedat, M., Muir, T.W., MacKinnon, R. (2004). Glycine as a D-amino acid surrogate in the K+-selectivity filter. PNAS, 101(49), 17045-17049. PubMed PMID: 15563591; PubMed Central PMCID: 535378.
  39. Jiang, Q.X., Wang, D.N., MacKinnon, R. (2004). Electron microscopic analysis of KvAP voltage-dependent K+ channels in an open conformation. Nature, 430(7001), 806-810. PubMed PMID: 15306816.
  40. Lee, S.Y., MacKinnon, R. (2004). A membrane-access mechanism of ion channel inhibition by voltage sensor toxins from spider venom. Nature, 430(6996), 232-235. PubMed PMID: 15241419.
  41. Valiyaveetil, F.I., Sekedat, M., Muir, T.W., MacKinnon, R. (2004). Semisynthesis of a functional K+ channel. Angew Chem Int Ed Engl, 43(19), 2504-2507. PubMed PMID: 15127436.
  42. Zhou, M., MacKinnon, R. (2004). A mutant KcsA K+ channel with altered conduction properties and selectivity filter ion distribution. J Mol Biol, 338(4), 839-846. PubMed PMID: 15099749.
  43. Zhou, Y., MacKinnon, R. (2004). Ion binding affinity in the cavity of the KcsA potassium channel. Biochemistry, 43(17), 4978-4982. PubMed PMID: 15109256.
  44. Zhou, Y., MacKinnon, R. (2003). The occupancy of ions in the K+ selectivity filter: charge balance and coupling of ion binding to a protein conformational change underlie high conduction rates. J Mol Biol, 333(5), 965-975. PubMed PMID: 14583193.
  45. Jiang, Y., Ruta,V., Chen, J., Lee, A., MacKinnon, R. (2003). The principle of gating charge movement in a voltage-dependent K+ channel. Nature, 423(6935), 42-48. PubMed PMID: 12721619.
  46. Jiang, Y., Lee, A., Chen, J., Ruta, V., Cadene, M., Chait, B.T., MacKinnon, R. (2003). X-ray structure of a voltage-dependent K+ channel. Nature, 423(6935), 33-41. PubMed PMID: 12721618.
  47. Dutzler, R., Campbell, E.B., MacKinnon, R. (2003). Gating the selectivity filter in ClC chloride channels. Science, 300(5616), 108-112. PubMed PMID: 12649487.
  48. Ruta V, Jiang Y, Lee A, Chen J, MacKinnon R. (2003). Functional analysis of an archaebacterial voltage-dependent K+ channel. Nature, 422(6928), 180-185. PubMed PMID: 12629550.
  49. Nishida, M., MacKinnon, R. (2002). Structural basis of inward rectification: Cytoplasmic pore of the G protein-gated inward rectifier GIRK1 at 1.8 Å resolution. Cell, 111(7), 957-965. PubMed PMID: 12507423.
  50. Yifrach, O., MacKinnon, R. (2002). Energetics of pore opening in a voltage-gated K+ channel. Cell, 111(2), 231-239. PubMed PMID: 12408867.
  51. Valiyaveetil, F.I., Zhou, Y., MacKinnon, R. (2002). Lipids in the structure, folding, and function of the KcsA K+ channel. Biochemistry, 41(35), 10771-10777. PubMed PMID: 12196015.
  52. Valiyaveetil, F.I., MacKinnon, R., Muir, T.W. (2002). Semisynthesis and folding of the potassium channel KcsA. J Am Chem Soc, 124(31), 9113-9120. PubMed PMID: 12149015.
  53. Jiang, Y., Lee, A., Chen, J., Cadene, M., Chait, B.T., MacKinnon, R. (2002). The open pore conformation of potassium channels. Nature, 417(6888), 523-526. PubMed PMID: 12037560.
  54. Jiang, Y., Lee, A., Chen, J., Cadene, M., Chait, B.T., MacKinnon, R. (2002). Crystal structure and mechanism of a calcium-gated potassium channel. Nature, 417(6888), 515-522. PubMed PMID: 12037559.
  55. Dutzler, R., Campbell, E.B., Cadene, M., Chait, B.T., MacKinnon, R. (2002). X-ray structure of a ClC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity. Nature, 415(6869), 287-294. PubMed PMID: 11796999.
  56. Zhou, Y., Morais-Cabral, J.H., Kaufman, A., MacKinnon, R. (2001). Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 Å resolution. Nature, 414(6859), 43-48. PubMed PMID: 11689936.
  57. Morais-Cabral, J.H., Zhou, Y., MacKinnon, R. (2001). Energetic optimization of ion conduction rate by the K+ selectivity filter. Nature, 414(6859), 37-42. PubMed PMID: 11689935.
  58. Zhou, M., Morais-Cabral, J., Mann, S., MacKinnon, R. (2001). Potassium channel receptor site for the inactivation gate and quaternary amine inhibitors. Nature, 411(6838), 657-661. PubMed PMID: 11395760.
  59. Jiang, Y., Pico, A., Cadene, M., Chait, B., MacKinnon, R. (2001). Structure of the RCK domain from the E. coli K+ channel and demonstration of its presence in the human BK channel. Neuron, 29(3), 593-601. PubMed PMID: 11301020.
  60. Gulbis, J.M., Zhou, M., Mann, S., MacKinnon, R. (2000). Structure of the cytoplasmic ß subunit--T1 assembly of voltage-dependent K+ channels. Science, 289(5476), 123-127. PubMed PMID: 10884227.
  61. Jiang, Y., MacKinnon, R. (2000). The barium site in a potassium channel by x-ray crystallography. J Gen Physiol, 115(3), 269-272. PubMed PMID: 10694255; PubMed PMCID: 2217209.
  62. Imredy, J.P., MacKinnon, R. (2000). Energetic and structural interactions between d-dendrotoxin and voltage-gated potassium channel. J Mol Biology, 296(5), 1283-1294. PubMed PMID: 10698633.
  63. Morrill, J.A., MacKinnon, R. (1999). Isolation of a single carboxyl-carboxylate proton binding site in the pore of a cyclic nucleotide-gated channel.  J Gen. Physiol, 114(1), 71-84. PubMed PMID: 10398693; PubMed PMCID: 2229637.
  64. Roux, B., MacKinnon, R. (1999). The cavity and pore helices in the KcsA K+ channel: electrostatic stabilization of monovalent cations.  Science, 285(5424), 100-102. PubMed PMID: 10390357.
  65. Gulbis, J.M., Mann, S., MacKinnon, R. (1999). Structure of a voltage-dependent K+ channel ß subunit. Cell, 97(7), 943-952. PubMed PMID: 10399921.
  66. Morais Cabral, J.H., Lee, A., Cohen, S.L., Chait, B.T., Li, M., MacKinnon, R. (1998). Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain. Cell, 95(5), 649-655. PubMed PMID: 9845367.
  67. Imredy, J., Chen, C., MacKinnon, R. (1998). A snake toxin inhibitor of inward rectifier potassium channel ROMK1. Biochemistry, 37(42), 14867-14874. PubMed PMID: 9778362.
  68. MacKinnon, R., Cohen, S.L., Kuo, A., Lee, A., Chait, B.T. (1998). Structural conservation in prokaryotic and eukaryotic potassium channels. Science, 280(5360), 106-109. PubMed PMID: 9525854.
  69. Doyle, D.A., Cabral, J.M., Pfuetzner, R.A., Kuo, A., Gulbis, J.M., Cohen, S.L., Chait, B.T., MacKinnon, R. (1998). The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science, 280(5360): 69-77. PubMed PMID: 9525859.
  70. Lu, Z., MacKinnon, R. (1997). Purification, characterization, and synthesis of an inward-rectifier K+ channel inhibitor from scorpion venom.  Biochemistry, 36(23), 6936-6940. PubMed PMID: 9188688.
  71. Swartz, K.J., MacKinnon, R. (1997). Mapping the receptor site for Hanatoxin, a gating modifier of voltage-dependent K+ channels. Neuron, 18(4), 675-682. PubMed PMID: 9136775.
  72. Swartz, K.J., MacKinnon, R. (1997). Hanatoxin modifies the gating of a voltage-dependent K+ channel through multiple binding sites. Neuron, 18(4), 665-673. PubMed PMID: 9136774.
  73. Doyle, D.A., Lee, A., Lewis, J., Kim, E., Sheng, M., MacKinnon, R. (1996). Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ. Cell, 85(7),1067-1076. PubMed PMID: 8674113.
  74. Aggarwal, S.K., MacKinnon, R. (1996). Contribution of the S4 segment to gating charge in the Shaker K+ channel. Neuron, 16(6), 1169-1177. PubMed PMID: 9136775.
  75. Gross, A., MacKinnon, R. (1996). Agitoxin footprinting the Shaker potassium channel pore. Neuron, 16(2), 399-406. PubMed PMID: 8789954.
  76. Ranganathan, R., Lewis, J., MacKinnon, R. (1996). Spatial localization of the K+ channel selectivity filter by mutant cycle-based structure analysis. Neuron, 16(1), 131-139. PubMed PMID: 8562077.
  77. Park, C.S., MacKinnon, R. (1995). Divalent cation selectivity in a cyclic nucleotide-gated ion channel. Biochemistry, 34(41). 13328-13333. PubMed PMID: 7577917.
  78. Lu, Z., MacKinnon, R. (1995). Probing a potassium channel pore with an engineered protonatable site. Biochemistry, 34(40), 13133-13138. PubMed PMID: 7548074.
  79. Swartz, K., MacKinnon, R. (1995). An Inhibitor of the Kv2.1 potassium channel isolated from the venom of a Chilean tarantula. Neuron, 15(4), 941-949. PubMed PMID: 7576642.
  80. Krezel, A., Khasibhatla, C., Hidalgo, P., MacKinnon, R., Wagner, G. (1995). Solution structure of the potassium channel inhibitor agitoxin 2:  Caliper for probing channel geometry. Protein Science, 4(8), 1478-1489. PubMed PMID: 8520473.
  81. Hidalgo, P., MacKinnon, R. (1995). Revealing the architecture of a K+ channel pore through mutant cycles with a peptide inhibitor. Science, 268(5208), 307-310. PubMed PMID: 7716527.
  82. Gross, A., Abramson, T., MacKinnon, R. (1994). Transfer of the scorpion toxin receptor to an insensitive potassium channel. Neuron, 13(4), 961-966. PubMed PMID: 7946339.
  83. Lu, Z., MacKinnon, R. (1994). Electrostatic tuning of Mg2+ affinity in an inward-rectifier K+ channel. Nature, 371(6494), 243-246. PubMed PMID: 7915826.
  84. Root, M.J., MacKinnon, R. (1994). Two identical noninteracting sites in an ion channel revealed by proton transfer. Science, 265(5180), 1852-1856. PubMed PMID: 7522344.
  85. Lu, Z., MacKinnon, R. (1994). A conductance maximum observed in an inward-rectifier potassium channel. J Gen Physiol, 104(3), 477-486. PubMed PMID: 7807057.
  86. Garcia, M.L., Garcia-Calvo, M., Hidalgo, P., Lee, A., MacKinnon, R. (1994). Purification and characterization of three inhibitors of voltage-dependent K+ channels from Leiurus Quinquestriatus var. Hebraeus venom.  Biochemistry, 33(22), 6834-6839. PubMed PMID: 8204618.
  87. Heginbotham, L., Lu, Z., Abramson, T., MacKinnon, R. (1994). Mutations in the K+ channel signature sequence. Biophysical J, 66(4), 1061-1067. PubMed PMID: 8038378.
  88. MacKinnon, R., Aldrich, R.W., Lee, A.W. (1993). Functional stoichiometry of Shaker potassium channel inactivation. Science, 262(5134), 757-759. PubMed PMID: 7694359.
  89. Heginbotham, L., MacKinnon, R. (1993). Conduction properties of the cloned Shaker K+ channel. Biophysical J, 65(5), 2089-2096. PubMed PMID: 8298038.
  90. Root, M., MacKinnon, R. (1993). Identification of an external divalent cation-binding site in the pore of a cGMP-activated channel. Neuron, 11(3), 459-466. PubMed PMID: 7691102.
  91. Perozo, E., MacKinnon, R., Bezanilla, F., Stefani, E. (1993). Gating currents from a nonconducting mutant reveal open-closed conformations in Shaker K+ channels.  Neuron, 11(2), 353-358. PubMed PMID: 8352943.
  92. Escobar, L., Root, M., MacKinnon, R. (1993). Influence of protein surface charge on the bimolecular kinetics of a potassium channel peptide inhibitor. Biochemistry, 32(27), 6982-6987. PubMed PMID: 7687466.
  93. Heginbotham, L., Abramson, T., MacKinnon, R. (1992). A functional connection between the pores of distantly related ion channels as revealed by mutant K+ channels. Science, 258(5085), 1152-1155. PubMed PMID: 1279807.
  94. Heginbotham, L., MacKinnon, R. (1992). The aromatic binding site for tetraethylammonium ion on potassium channels. Neuron, 8(3), 483-491. PubMed PMID: 1550673.
  95. MacKinnon, R. (1991). Determination of the subunit stoichiometry of a voltage-activated potassium channel. Nature, 350(6315), 232-235. PubMed PMID: 1706481.
  96. Yellen, G., Jurman, M., Abramson, T., MacKinnon, R. (1991). Mutations affecting internal TEA blockade identify the probable pore-forming region of a K+ channel. Science, 251(4996), 939-942. PubMed PMID: 2000494.
  97. MacKinnon, R., Yellen, G. (1990). Mutations affecting TEA blockade and ion permeation in voltage-activated K+ channels. Science, 250(4978), 276-279. PubMed PMID: 2218530.
  98. MacKinnon, R., Heginbotham, L., Abramson, T. (1990). Mapping the receptor site for charybdotoxin, a pore-blocking potassium channel inhibitor. Neuron, 5(6): 767-771. PubMed PMID: 1702643.
  99. Schumaker, M., MacKinnon, R. (1990). A simple model for multi-ion permeation:  single-vacancy conduction in a simple pore model. Biophysical J, 58(4), 975-984. PubMed PMID: 1701102.
  100. MacKinnon, R., Miller, C. (1989). Mutant potassium channels with altered binding of charybdotoxin, a pore-blocking peptide inhibitor. Science, 245(4924), 1382-1385. PubMed PMID: 2476850.
  101. MacKinnon, R., Latorre R, Miller, C. (1989). Role of surface electrostatics in the operation of a high-conductance Ca2+-activated K+ channel.  Biochemistry, 28(20), 8092-8099. PubMed PMID: 2605175.
  102. MacKinnon, R., Miller, C. (1989). Functional modification of Ca2+-activated K+ channel by trimethyloxonium. Biochemistry, 28(20), 8087-8092. PubMed PMID: 2481495.
  103. MacKinnon, R., Reinhart, P., White, M. (1988). Charybdotoxin block of Shaker K+ channels suggests that different types of K+ channels share common structural features.  Neuron, 1(10), 997-1001. PubMed PMID: 2483094.
  104. MacKinnon, R., Miller, C. (1988). Mechanism of charybdotoxin block of the high-conductance Ca2+-activated K+ channel. J Gen Physiol, 91(3), 335-349. PubMed PMID: 2454283.
  105. Anderson, C.S., MacKinnon, R., Smith, C., Miller, C. (1988). Charybdotoxin block of single Ca2+- activated K+ channels: Effects of channel gating, voltage, and ionic strength. J Gen Physiol, 91(3), 317-333. PubMed PMID: 2454282.
  106. MacKinnon, R., Gwathmey, J., Allen, P., Briggs, M., Morgan, J.P. (1988). Modulation by the thyroid state of intracellular calcium and contractility in ferret ventricular muscle. Circ Res, 63(6), 1080-1089. PubMed PMID: 3197273.
  107. MacKinnon, R., Gwathmey, J., Morgan, J.P. (1987). Differential effects of reoxygenation on intracellular calcium and isometric tension. Pflugers Arch, 409(4-5), 448-453. PubMed PMID: 3627961.
  108. MacKinnon, R., Morgan, J.P. (1986). Influence of the thyroid state on the calcium transient in ventricular muscle. Pflugers Arch, 407(2), 142-144. PubMed PMID: 2428004.

 

Review Articles:

 

  1. Gouaux, E., MacKinnon, R. (2005). Principles of selective ion transport in channels and pumps. Science, 310(5753), 1461-1465. PubMed PMID: 16322449.
  2. MacKinnon, R. (2005). Membrane protein insertion and stability. Science, 307(5714), 1425-1426. PubMed PMID: 15746418.
  3. MacKinnon, R. (2004). Voltage sensor meets lipid membrane. Science, 306(5700), 1304-1305. PubMed PMID: 15550651.
  4. MacKinnon, R. (2004). Potassium channels and the atomic basis of selective ion conduction (Nobel Lecture). Angew Chem Int Ed Engl, 43(33), 4265-4277. PubMed PMID: 15368373.
  5. MacKinnon, R. (2003). Potassium channels. FEBS Letter 555(1), 62-65. PubMed PMID: 14630320.