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Publications

  1. Touhara, K.K., Wang, W., MacKinnon, R. (2016). The GIRK1 subunit potentiates G protein activation of cardiac GIRK1/4 hetero-tetramers. eLife, 2016 Apr 13;5. pii: e15750. doi: 10.7554/eLife.15750. [Epub ahead of print]. PubMed PMID: 27074664. PubMed Central PMCID: in process.  Full Text: eLife.15750
  2.  Wang, W., Touhara, K.K., Weir, K., Bean, B.P., MacKinnon, R. (2016). Cooperative regulation by G proteins and Na+ of neuronal GIRK2 K+ channels. eLife, 2016 Apr 13;5. pii: e15751. doi: 10.7554/eLife.15751. [Epub ahead of print]. PubMed PMID: 27074662. PubMed Central PMCID: in process.  Full Text: eLife.15751
  3.  Su, Z., Brown, E. C., Wang, W., MacKinnon, R. (2016). Novel cell-free high-throughput screening method for pharmacological tools targeting K+ channels. PNAS, 2016 Apr 18. pii: 201602815. [Epub ahead of print]. Pub Med PMID: 27091997. PubMed Central PMCID: in process. Full Text: http://www.pnas.org/content/early/2016/04/15/1602815113.long
  4.  Hite, R.K., Peng, Y., Li, Z., Hsuing, Y., Walz, T., MacKinnon, R. (2015). Cryo-EM structure of the Slo2.2 Na+-activated K+ channel. Nature, DOI: 10.1038/nature14958. PMID: 26436452.  PMCID: in process.  Full text: http://www.nature.com/nature/journal/v527/n7577/full/nature14958.html
  5. Brohawn, S.G., Campbell, E.B., MacKinnon, R. (2014). Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel. Nature, 516 (7529): 126-30.  PMID: 25471887. PMCID: 4682367. HHMIMSID: HHMIMS639323. PMC Full Text:  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682367/pdf/nihms639323.pdf
  6. Hite, R. K., Butterwick, J.A., MacKinnon, R. (2014). Phosphatidic acid modulation of Kv channel voltage sensor function. eLife 2014; DOI: http://dx.doi.org/10.7554/eLife.04366.  PMID: 25285449. PMCID: 4212207.  PMC Full Text:  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212207/pdf/elife04366.pdf
  7. Wang, W., Whorton, M.R., MacKinnon, R. (2014). Quantitative analysis of mammalian GIRK2 channel regulation by G proteins, the signaling lipid PIP2 and Na+ in a reconstituted system. eLife 2014;3:e03671. DOI: 10.7554/eLife.03671. PubMed PMID#: 25049222. PubMed Central PMCID: 4135351.  PMC Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135351/pdf/elife03671.pdf
  8. Brohawn, S.G., Su, Z., MacKinnon, R. (2014). Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K+ channels. PNAS, published ahead of print. PubMED PMID: 24550493; PubMed Central PMCID: 3948252.  PMC Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948252/pdf/pnas.201320768.pdf
  9. Whorton, M.R., MacKinnon, R. (2013). X-ray structure of the mammalian GIRK2-βγ G-protein complex. Nature, published online June 5. PubMED PMID: 23739333.  PMCID: 4654628.  PMC Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654628/pdf/nihms475967.pdf
  10. Banerjee, A., Lee, A., Campbell, E., MacKinnon, R. (2013). Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K+ channel. eLife 2013; e00594. PubMED PMID: 23705070; PubMed Central PMCID: 3360741. PMC Full Text:  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660741/pdf/elife00594.pdf
  11. Brohawn, S.G., Campbell, E.B., MacKinnon, R. (2013). Domain-swapped chain connectivity and gated membrane access in a Fab-mediated crystal of the human TRAAK K+ channel. PNAS, 110(6). PubMED PMID: 23341632; PubMed Central PMCID: 358379.  PMC Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568379/pdf/pnas.201218950.pdf
  12. Leonetti, M.D., Yuan, P., Hsiung, Y., MacKinnon, R. (2012). Functional and structural analysis of the human SLO3 pH- and voltage-gated K+ channel. PNAS, 109(47), 19274-279. PMID: 23129643 [PubMed - indexed for MEDLINE] PMCID: 3511096. PMC Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511096/pdf/pnas.201215078.pdf
  13. Feng, L., Campbell, E.B., MacKinnon, R. (2012). Molecular mechanism of proton transport in CLC Cl-/H+ exchange transporters. PNAS, 109(29), 11699-704. PubMed PMID: 22753511; PubMed Central PMCID: 3406864.  PMC Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406864/pdf/pnas.1205764109.pdf
  14. Schmidt, D., del Marmol, J., MacKinnon, R. (2012). Mechanistic basis for low threshold mechanosensitivity in voltage-dependent K+ channels. PNAS, 109(26), 10352-7. PubMed PMID: 22675122; PubMed Central PMCID: 3387069.  PMC Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387069/pdf/pnas.1204700109.pdf
  15. Brohawn, S.G., del Mármol, J., MacKinnon, R. (2012). Crystal Structure of the Human K2P TRAAK, a Lipid- and Mechano-Sensitive K+ Ion Channel. Science, 335 (6067), 436-441. PubMed PMID: 22282805; PubMed Central PMCID: 3329120.  PMC Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329120/pdf/nihms367931.pdf
  16. Yuan P., Leonetti M.D., Hsiung, Y., MacKinnon, R. (2011) Open structure of the Ca2+ gating ring in the high-conductance Ca2+-activated K+ channel. Nature, 481 (7379), 94-97PubMed PMID: 22139424; PubMed Central PMCID: 3319005. PMC Full Text:  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319005/pdf/nihms359917.pdf
  17. Whorton, M.R., MacKinnon, R. (2011). Crystal structure of the mammalian GIRK2 K+ channel and gating regulation by G proteins, PIP(2), and sodium. Cell, 147(1), 199-208. PubMed PMID: 21962516; PubMed Central PMCID: 3243363.  PMC Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243363/pdf/nihms330339.pdf
  18. Hansen, S.B., Tao, X., MacKinnon, R. (2011). Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2. Nature, 477(7365), 495-8. PubMed PMID: 21874019; PubMed Central PMCID: 3324908.  PMC Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324908/pdf/nihms352299.pdf
  19. Feng, L., Campbell, E.B., Hsiung, Y.C., MacKinnon, R. (2010). Structure of a eukaryotic CLC transporter defines an intermediate state in the transport cycle. Science, 330(6004), 635-41. PubMed PMID: 20929736; PubMed Central PMCID: 3079386.  PMC Full Text:  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079386/pdf/nihms259637.pdf
  20. Butterwick, J.A., MacKinnon, R. (2010). Solution structure and phospholipid interactions of the isolated voltage-sensor domain from KvAP. J Mol Biology, 403(4), 591-606. PubMed PMID: 20851706; PubMed Central PMCID: 2971526.  PMC Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2971526/pdf/nihms244047.pdf
  21. Yuan, P., Leonetti, M., Pico, A.R., Hsiung, Y.C., MacKinnon, R. (2010). Structure of the human BK channel Ca2+-activation apparatus at 3.0 Å resolution. Science, 329(5988), 182-6. PubMed PMID: 20508092; PubMed Central PMCID: 3022345.  PMC Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022345/pdf/nihms259636.pdf
  22. Tao, X., Lee, A., Limapichat, W., Dougherty, D.A., MacKinnon, R. (2010). A gating charge transfer center in voltage sensors. Science, 328(5974), 67-73. PubMed PMID: 20360102; PubMed Central PMCID: 2869078.  PMC Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2869078/pdf/nihms201352.pdf
  23. Tao, X., Avalos, J.L., Chen, J., MacKinnon, R. (2009). Crystal structure of the eukaryotic strong inward-rectifier K+ channel Kir2.2 at 3.1 Å resolution. Science, 326(5960), 1668-74. PubMed PMID: 20019282; PubMed Central PMCID: 2819303.  PMC Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819303/pdf/nihms172625.pdf
  24. Endeward, B., Butterwick, J.A., MacKinnon, R., Prisner, T.F. (2009). Pulsed electron-electron double-resonance determination of spin-label distances and orientations on the tetrameric potassium ion channel KcsA. J Am Chem Soc, 131(42), 15246-50. PubMed PMID: 19919160; PubMed Central PMCID: 2779547. PMC Full Text:  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779547/pdf/nihms154720.pdf
  25. Schmidt, D., Cross, S.R., MacKinnon, R. (2009). A gating model for the archeal voltage-dependent K+ channel KvAP in DPhPC and POPE: POPG decane lipid bilayers. J Mol Biology, 390(5), 902-12. PubMed PMID: 19481093; PubMed Central PMCID: 2778279. PMC Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778279/pdf/nihms119991.pdf
  26. Lee, S.Y., Letts, J.A., MacKinnon, R. (2009). Functional reconstitution of purified human Hv1 H+ Channels. J Mol Biology, 387(5), 1055-60. PubMed PMID: 19233200; PubMed Central PMCID: 2778278.  PMC Full Text:  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778278/pdf/nihms111560.pdf
  27. Lee, S.Y., Banerjee, A., MacKinnon, R. (2009). Two separate interfaces between the voltage sensor and pore are required for the function of voltage-dependent K+ Channels. PLoS Biology, 7(3), e47. PubMed PMID: 19260762; PubMed Central PMCID: 2650729. PMC Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650729/pdf/pbio.1000047.pdf
  28. Schmidt, D., MacKinnon, R. (2008). Voltage-dependent K+ channel gating and voltage sensor toxin sensitivity depend on the mechanical state of the lipid membrane. PNAS, 105(49), 19276-19281. PubMed PMID: 19050073; PubMed Central PMCID: 2614752. PMC Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2614752/pdf/zpq19276.pdf
  29. Tao, X., MacKinnon, R. (2008). Functional analysis of Kv1.2 and paddle chimera Kv channels in planar lipid bilayers. J Mol Biology, 382(1), 24-33. Epub 2008 Jul 7. PubMed PMID: 18638484; PubMed Central PMCID: 2825521. PMC Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825521/pdf/nihms69486.pdf
  30. Banerjee, A., MacKinnon, R. (2008). Inferred motions of the S3a helix during voltage-dependent K+ channel gating. J Mol Biology, 381(3), 569-80. Epub 2008 Jun 10. PubMed PMID: 18632115; PubMed Central PMCID: 2819426. PMC Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819426/pdf/nihms-65209.pdf
  31. Lee, S.Y., Letts, J.A., MacKinnon, R. (2008). Dimeric subunit stoichiometry of the human voltage-dependent proton channel Hv1. PNAS, 105(22), 7692-7695. PubMed PMID: 18509058; PubMed Central PMCID: 2409406. PMC Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409406/pdf/zpq7692.pdf
  32. Nishida, M., Cadene, M., Chait, B.T., MacKinnon, R. (2007). Crystal structure of a Kir3.1-prokaryotic Kir channel chimera. EMBO J, 26(17), 4005-4015. PubMed PMID: 17703190; PubMed Central PMCID: 1994128.  PMC Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1994128/pdf/7601828a.pdf
  33. Long, S.B., Tao X., Campbell, E.B., MacKinnon, R. (2007). Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment. Nature, 450(7168), 376-382. PubMed PMID: 18004376.   Full Text: http://www.nature.com/nature/journal/v450/n7168/full/nature06265.html
  34. Lockless, S.W., Zhou, M., MacKinnon, R. (2007). Structural and thermodynamic properties of selective ion binding in a K+ channel. PLoS Biology, 5(5), e121. PubMed PMID: 17472437; PubMed Central PMCID: 1858713. PMC Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1858713/pdf/pbio.0050121.pdf
  35. Schmidt, D., Jiang, Q.X., MacKinnon, R. (2006). Phospholipids and the origin of cationic gating charges in voltage sensors. Nature, 444(7120), 775-779. PubMed PMID: 17136096.  Full Text: http://www.nature.com/nature/journal/v444/n7120/full/nature05416.html
  36. Valiyaveetil, F.I., Leonetti, M., Muir, T.W., MacKinnon, R. (2006). Ion selectivity in a semisynthetic K+ channel locked in the conductive conformation. Science, 314(5801), 1004-1007. PubMed PMID: 17095703.  Full Text: http://classic.sciencemag.org/content/314/5801/1004.long
  37. Valiyaveetil, F.I., Sekedat, M., MacKinnon, R., Muir, T.W. (2006). Structural and functional consequences of an amide-to-ester substitution in the selectivity filter of a potassium channel. J Am Chem Soc, 128(35), 11591-11599. PubMed PMID: 16939283; PubMed Central PMCID: 2546570. PMC Full Text:  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2546570/
  38. Lee, S.Y., Lee, A., Chen, J.Y., MacKinnon, R. (2005). Structure of the KvAP voltage-dependent K+ channel and its dependence on the lipid membrane. PNAS, 102(43): 15441-15446. PubMed PMID: 16223877; PubMed Central PMCID: 1253646.  PMC Full Text: http://www.ncbi.nlm.nih.gov/pubmed/?term=16223877
  39. Ruta, V., Chen, J.Y., MacKinnon, R. (2005). Calibrated measurement of gating charge arginine displacement in the KvAP voltage-dependent K+ channel. Cell, 123(3), 463-475. PubMed PMID: 16269337.  Full Text: http://www.sciencedirect.com/science/article/pii/S0092867405009128
  40. Long, S.B., Campbell, E.B., MacKinnon, R. (2005). Voltage sensor of Kv1.2: structural basis of electromechanical coupling. Science, 309(5736), 903-908. PubMed PMID: 16002579.  Full Text: http://science.sciencemag.org/content/309/5736/903.long
  41. Long, S.B., Campbell, E.B., MacKinnon R. (2005). Crystal structure of a mammalian voltage-dependent Shaker family K+ channel. Science, 309(5736), 897-903. PubMed PMID: 16002581.  Full Text:  http://science.sciencemag.org/content/309/5736/897.long
  42. Ohndorf, U.M., MacKinnon, R. (2005). Construction of a cyclic nucleotide-gated KcsA K+ channel. J Mol Biol, 350(5), 857-865. PubMed PMID: 15979092.  Full Text:  http://www.sciencedirect.com/science/article/pii/S0022283605006054
  43. Ruta, V., MacKinnon, R. (2004). Localization of the voltage-sensor toxin receptor on KvAP. Biochemistry, 43(31), 10071-10079. PubMed PMID: 15287735.  Full Text:  http://pubs.acs.org/doi/abs/10.1021/bi049463y
  44. Valiyaveetil, F.I., Sekedat, M., Muir, T.W., MacKinnon, R. (2004). Glycine as a D-amino acid surrogate in the K+-selectivity filter. PNAS, 101(49), 17045-17049. PubMed PMID: 15563591; PubMed Central PMCID: 535378.  PMC Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC535378/
  45. Jiang, Q.X., Wang, D.N., MacKinnon, R. (2004). Electron microscopic analysis of KvAP voltage-dependent K+ channels in an open conformation. Nature, 430(7001), 806-810. PubMed PMID: 15306816. Full Text:  http://www.nature.com/nature/journal/v430/n7001/full/nature02735.html
  46. Lee, S.Y., MacKinnon, R. (2004). A membrane-access mechanism of ion channel inhibition by voltage sensor toxins from spider venom. Nature, 430(6996), 232-235. PubMed PMID: 15241419.  Full Text:  http://www.nature.com/nature/journal/v430/n6996/full/nature02632.html
  47. Valiyaveetil, F.I., Sekedat, M., Muir, T.W., MacKinnon, R. (2004). Semisynthesis of a functional K+ channel. Angew Chem Int Ed Engl, 43(19), 2504-2507. PubMed PMID: 15127436.  Full Text: http://onlinelibrary.wiley.com/doi/10.1002/anie.2004538 abstract;jsessionid=1F222A4C931ABC4CA96D5ADD59AB220C.f03t04
  48. Zhou, M., MacKinnon, R. (2004). A mutant KcsA K+ channel with altered conduction properties and selectivity filter ion distribution. J Mol Biol, 338(4), 839-846. PubMed PMID: 15099749.  Full Text:  http://www.sciencedirect.com/science/article/pii/S0022283604003109
  49. Zhou, Y., MacKinnon, R. (2004). Ion binding affinity in the cavity of the KcsA potassium channel. Biochemistry, 43(17), 4978-4982. PubMed PMID: 15109256.
  50. Zhou, Y., MacKinnon, R. (2003). The occupancy of ions in the K+ selectivity filter: charge balance and coupling of ion binding to a protein conformational change underlie high conduction rates. J Mol Biol, 333(5), 965-975. PubMed PMID: 14583193.  Full Text: http://www.ncbi.nlm.nih.gov/pubmed/?term=14583193
  51. Jiang, Y., Ruta,V., Chen, J., Lee, A., MacKinnon, R. (2003). The principle of gating charge movement in a voltage-dependent K+ channel. Nature, 423(6935), 42-48. PubMed PMID: 12721619.  Full Text:  http://www.nature.com/nature/journal/v423/n6935/full/nature01581.html
  52. Jiang, Y., Lee, A., Chen, J., Ruta, V., Cadene, M., Chait, B.T., MacKinnon, R. (2003). X-ray structure of a voltage-dependent K+ channel. Nature, 423(6935), 33-41. PubMed PMID: 12721618.  Full Text:  http://www.ncbi.nlm.nih.gov/pubmed/?term=12721618
  53. Dutzler, R., Campbell, E.B., MacKinnon, R. (2003). Gating the selectivity filter in ClC chloride channels. Science, 300(5616), 108-112. PubMed PMID: 12649487. Full Text: http://science.sciencemag.org/content/300/5616/108.long
  54. Ruta V, Jiang Y, Lee A, Chen J, MacKinnon R. (2003). Functional analysis of an archaebacterial voltage-dependent K+ channel. Nature, 422(6928), 180-185. PubMed PMID: 12629550.  Full Text: nature01473
  55. Nishida, M., MacKinnon, R. (2002). Structural basis of inward rectification: Cytoplasmic pore of the G protein-gated inward rectifier GIRK1 at 1.8 Å resolution. Cell, 111(7), 957-965. PubMed PMID: 12507423.  Full Text: http://www.sciencedirect.com/science/article/pii/S0092867402012278
  56. Yifrach, O., MacKinnon, R. (2002). Energetics of pore opening in a voltage-gated K+ channel. Cell, 111(2), 231-239. PubMed PMID: 12408867.  Full Text:http://www.sciencedirect.com/science/article/pii/S0092867402010139 
  57. Valiyaveetil, F.I., Zhou, Y., MacKinnon, R. (2002). Lipids in the structure, folding, and function of the KcsA K+ channel. Biochemistry, 41(35), 10771-10777. PubMed PMID: 12196015.  Full Text: http://pubs.acs.org/doi/abs/10.1021/bi026215y
  58. Valiyaveetil, F.I., MacKinnon, R., Muir, T.W. (2002). Semisynthesis and folding of the potassium channel KcsA. J Am Chem Soc, 124(31), 9113-9120. PubMed PMID: 12149015.  Full Text: http://pubs.acs.org/doi/abs/10.1021/ja0266722
  59. Jiang, Y., Lee, A., Chen, J., Cadene, M., Chait, B.T., MacKinnon, R. (2002). The open pore conformation of potassium channels. Nature, 417(6888), 523-526. PubMed PMID: 12037560. Full Text: http://www.nature.com/nature/journal/v417/n6888/full/417523a.html
  60. Jiang, Y., Lee, A., Chen, J., Cadene, M., Chait, B.T., MacKinnon, R. (2002). Crystal structure and mechanism of a calcium-gated potassium channel. Nature, 417(6888), 515-522. PubMed PMID: 12037559. Full Text: http://www.nature.com/nature/journal/v417/n6888/full/417515a.html
  61. Dutzler, R., Campbell, E.B., Cadene, M., Chait, B.T., MacKinnon, R. (2002). X-ray structure of a ClC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity. Nature, 415(6869), 287-294. PubMed PMID: 11796999.  Full Text: http://www.nature.com/nature/journal/v415/n6869/full/415287a.html
  62. Zhou, Y., Morais-Cabral, J.H., Kaufman, A., MacKinnon, R. (2001). Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 Å resolution. Nature, 414(6859), 43-48. PubMed PMID: 11689936. Full Text: http://www.nature.com/nature/journal/v414/n6859/full/414043a0.html
  63. Morais-Cabral, J.H., Zhou, Y., MacKinnon, R. (2001). Energetic optimization of ion conduction rate by the K+ selectivity filter. Nature, 414(6859), 37-42. PubMed PMID: 11689935.  Full Text: http://www.nature.com/nature/journal/v414/n6859/full/414037a0.html
  64. Zhou, M., Morais-Cabral, J., Mann, S., MacKinnon, R. (2001). Potassium channel receptor site for the inactivation gate and quaternary amine inhibitors. Nature, 411(6838), 657-661. PubMed PMID: 11395760. Full Text: http://www.nature.com/nature/journal/v411/n6838/full/411657a0.html
  65. Jiang, Y., Pico, A., Cadene, M., Chait, B., MacKinnon, R. (2001). Structure of the RCK domain from the E. coli K+ channel and demonstration of its presence in the human BK channel. Neuron, 29(3), 593-601. PubMed PMID: 11301020.  Full Text: http://www.sciencedirect.com/science/article/pii/S0896627301002367
  66. Gulbis, J.M., Zhou, M., Mann, S., MacKinnon, R. (2000). Structure of the cytoplasmic ß subunit--T1 assembly of voltage-dependent K+ channels. Science, 289(5476), 123-127. PubMed PMID: 10884227. Full Text: http://science.sciencemag.org/content/289/5476/123.long
  67. Jiang, Y., MacKinnon, R. (2000). The barium site in a potassium channel by x-ray crystallography. J Gen Physiol, 115(3), 269-272. PubMed PMID: 10694255; PubMed PMCID: 2217209. Full Text: http://jgp.rupress.org/content/115/3/269.long
  68. Imredy, J.P., MacKinnon, R. (2000). Energetic and structural interactions between d-dendrotoxin and voltage-gated potassium channel. J Mol Biology, 296(5), 1283-1294. PubMed PMID: 10698633. Full Text: http://www.sciencedirect.com/science/article/pii/S0022283600935228
  69. Morrill, J.A., MacKinnon, R. (1999). Isolation of a single carboxyl-carboxylate proton binding site in the pore of a cyclic nucleotide-gated channel.  J Gen. Physiol, 114(1), 71-84. PubMed PMID: 10398693; PubMed PMCID: 2229637.
  70. Roux, B., MacKinnon, R. (1999). The cavity and pore helices in the KcsA K+ channel: electrostatic stabilization of monovalent cations.  Science, 285(5424), 100-102. PubMed PMID: 10390357.
  71. Gulbis, J.M., Mann, S., MacKinnon, R. (1999). Structure of a voltage-dependent K+ channel ß subunit. Cell, 97(7), 943-952. PubMed PMID: 10399921.
  72. Morais Cabral, J.H., Lee, A., Cohen, S.L., Chait, B.T., Li, M., MacKinnon, R. (1998). Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain. Cell, 95(5), 649-655. PubMed PMID: 9845367.
  73. Imredy, J., Chen, C., MacKinnon, R. (1998). A snake toxin inhibitor of inward rectifier potassium channel ROMK1. Biochemistry, 37(42), 14867-14874. PubMed PMID: 9778362.
  74. MacKinnon, R., Cohen, S.L., Kuo, A., Lee, A., Chait, B.T. (1998). Structural conservation in prokaryotic and eukaryotic potassium channels. Science, 280(5360), 106-109. PubMed PMID: 9525854.
  75. Doyle, D.A., Cabral, J.M., Pfuetzner, R.A., Kuo, A., Gulbis, J.M., Cohen, S.L., Chait, B.T., MacKinnon, R. (1998). The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science, 280(5360): 69-77. PubMed PMID: 9525859.  Full Text: http://classic.sciencemag.org/content/280/5360/69.full.pdf
  76. Lu, Z., MacKinnon, R. (1997). Purification, characterization, and synthesis of an inward-rectifier K+ channel inhibitor from scorpion venom.  Biochemistry, 36(23), 6936-6940. PubMed PMID: 9188688.
  77. Swartz, K.J., MacKinnon, R. (1997). Mapping the receptor site for Hanatoxin, a gating modifier of voltage-dependent K+ channels. Neuron, 18(4), 675-682. PubMed PMID: 9136775.
  78. Swartz, K.J., MacKinnon, R. (1997). Hanatoxin modifies the gating of a voltage-dependent K+ channel through multiple binding sites. Neuron, 18(4), 665-673. PubMed PMID: 9136774.
  79. Doyle, D.A., Lee, A., Lewis, J., Kim, E., Sheng, M., MacKinnon, R. (1996). Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ. Cell, 85(7),1067-1076. PubMed PMID: 8674113.
  80. Aggarwal, S.K., MacKinnon, R. (1996). Contribution of the S4 segment to gating charge in the Shaker K+ channel. Neuron, 16(6), 1169-1177. PubMed PMID: 9136775.
  81. Gross, A., MacKinnon, R. (1996). Agitoxin footprinting the Shaker potassium channel pore. Neuron, 16(2), 399-406. PubMed PMID: 8789954.
  82. Ranganathan, R., Lewis, J., MacKinnon, R. (1996). Spatial localization of the K+ channel selectivity filter by mutant cycle-based structure analysis. Neuron, 16(1), 131-139. PubMed PMID: 8562077.
  83. Park, C.S., MacKinnon, R. (1995). Divalent cation selectivity in a cyclic nucleotide-gated ion channel. Biochemistry, 34(41). 13328-13333. PubMed PMID: 7577917.
  84. Lu, Z., MacKinnon, R. (1995). Probing a potassium channel pore with an engineered protonatable site. Biochemistry, 34(40), 13133-13138. PubMed PMID: 7548074.
  85. Swartz, K., MacKinnon, R. (1995). An Inhibitor of the Kv2.1 potassium channel isolated from the venom of a Chilean tarantula. Neuron, 15(4), 941-949. PubMed PMID: 7576642.
  86. Krezel, A., Khasibhatla, C., Hidalgo, P., MacKinnon, R., Wagner, G. (1995). Solution structure of the potassium channel inhibitor agitoxin 2:  Caliper for probing channel geometry. Protein Science, 4(8), 1478-1489. PubMed PMID: 8520473.
  87. Hidalgo, P., MacKinnon, R. (1995). Revealing the architecture of a K+ channel pore through mutant cycles with a peptide inhibitor. Science, 268(5208), 307-310. PubMed PMID: 7716527.
  88. Gross, A., Abramson, T., MacKinnon, R. (1994). Transfer of the scorpion toxin receptor to an insensitive potassium channel. Neuron, 13(4), 961-966. PubMed PMID: 7946339.
  89. Lu, Z., MacKinnon, R. (1994). Electrostatic tuning of Mg2+ affinity in an inward-rectifier K+ channel. Nature, 371(6494), 243-246. PubMed PMID: 7915826.
  90. Root, M.J., MacKinnon, R. (1994). Two identical noninteracting sites in an ion channel revealed by proton transfer. Science, 265(5180), 1852-1856. PubMed PMID: 7522344.
  91. Lu, Z., MacKinnon, R. (1994). A conductance maximum observed in an inward-rectifier potassium channel. J Gen Physiol, 104(3), 477-486. PubMed PMID: 7807057.
  92. Garcia, M.L., Garcia-Calvo, M., Hidalgo, P., Lee, A., MacKinnon, R. (1994). Purification and characterization of three inhibitors of voltage-dependent K+ channels from Leiurus Quinquestriatus var. Hebraeus venom.  Biochemistry, 33(22), 6834-6839. PubMed PMID: 8204618.
  93. Heginbotham, L., Lu, Z., Abramson, T., MacKinnon, R. (1994). Mutations in the K+ channel signature sequence. Biophysical J, 66(4), 1061-1067. PubMed PMID: 8038378.
  94. MacKinnon, R., Aldrich, R.W., Lee, A.W. (1993). Functional stoichiometry of Shaker potassium channel inactivation. Science, 262(5134), 757-759. PubMed PMID: 7694359.
  95. Heginbotham, L., MacKinnon, R. (1993). Conduction properties of the cloned Shaker K+ channel. Biophysical J, 65(5), 2089-2096. PubMed PMID: 8298038.
  96. Root, M., MacKinnon, R. (1993). Identification of an external divalent cation-binding site in the pore of a cGMP-activated channel. Neuron, 11(3), 459-466. PubMed PMID: 7691102.
  97. Perozo, E., MacKinnon, R., Bezanilla, F., Stefani, E. (1993). Gating currents from a nonconducting mutant reveal open-closed conformations in Shaker K+ channels.  Neuron, 11(2), 353-358. PubMed PMID: 8352943.
  98. Escobar, L., Root, M., MacKinnon, R. (1993). Influence of protein surface charge on the bimolecular kinetics of a potassium channel peptide inhibitor. Biochemistry, 32(27), 6982-6987. PubMed PMID: 7687466.
  99. Heginbotham, L., Abramson, T., MacKinnon, R. (1992). A functional connection between the pores of distantly related ion channels as revealed by mutant K+ channels. Science, 258(5085), 1152-1155. PubMed PMID: 1279807.
  100. Heginbotham, L., MacKinnon, R. (1992). The aromatic binding site for tetraethylammonium ion on potassium channels. Neuron, 8(3), 483-491. PubMed PMID: 1550673.
  101. MacKinnon, R. (1991). Determination of the subunit stoichiometry of a voltage-activated potassium channel. Nature, 350(6315), 232-235. PubMed PMID: 1706481.
  102. Yellen, G., Jurman, M., Abramson, T., MacKinnon, R. (1991). Mutations affecting internal TEA blockade identify the probable pore-forming region of a K+ channel. Science, 251(4996), 939-942. PubMed PMID: 2000494.
  103. MacKinnon, R., Yellen, G. (1990). Mutations affecting TEA blockade and ion permeation in voltage-activated K+ channels. Science, 250(4978), 276-279. PubMed PMID: 2218530.
  104. MacKinnon, R., Heginbotham, L., Abramson, T. (1990). Mapping the receptor site for charybdotoxin, a pore-blocking potassium channel inhibitor. Neuron, 5(6): 767-771. PubMed PMID: 1702643.
  105. Schumaker, M., MacKinnon, R. (1990). A simple model for multi-ion permeation:  single-vacancy conduction in a simple pore model. Biophysical J, 58(4), 975-984. PubMed PMID: 1701102.
  106. MacKinnon, R., Miller, C. (1989). Mutant potassium channels with altered binding of charybdotoxin, a pore-blocking peptide inhibitor. Science, 245(4924), 1382-1385. PubMed PMID: 2476850.
  107. MacKinnon, R., Latorre R, Miller, C. (1989). Role of surface electrostatics in the operation of a high-conductance Ca2+-activated K+ channel.  Biochemistry, 28(20), 8092-8099. PubMed PMID: 2605175.
  108. MacKinnon, R., Miller, C. (1989). Functional modification of Ca2+-activated K+ channel by trimethyloxonium. Biochemistry, 28(20), 8087-8092. PubMed PMID: 2481495.
  109. MacKinnon, R., Reinhart, P., White, M. (1988). Charybdotoxin block of Shaker K+ channels suggests that different types of K+ channels share common structural features.  Neuron, 1(10), 997-1001. PubMed PMID: 2483094.
  110. MacKinnon, R., Miller, C. (1988). Mechanism of charybdotoxin block of the high-conductance Ca2+-activated K+ channel. J Gen Physiol, 91(3), 335-349. PubMed PMID: 2454283.
  111. Anderson, C.S., MacKinnon, R., Smith, C., Miller, C. (1988). Charybdotoxin block of single Ca2+- activated K+ channels: Effects of channel gating, voltage, and ionic strength. J Gen Physiol, 91(3), 317-333. PubMed PMID: 2454282.
  112. MacKinnon, R., Gwathmey, J., Allen, P., Briggs, M., Morgan, J.P. (1988). Modulation by the thyroid state of intracellular calcium and contractility in ferret ventricular muscle. Circ Res, 63(6), 1080-1089. PubMed PMID: 3197273.
  113. MacKinnon, R., Gwathmey, J., Morgan, J.P. (1987). Differential effects of reoxygenation on intracellular calcium and isometric tension. Pflugers Arch, 409(4-5), 448-453. PubMed PMID: 3627961.
  114. Gwathmey JK, Copelas L, MacKinnon R, Schoen FJ, Feldman MD, Grossman W, Morgan JP. Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure. Circ Res. 1987 Jul;61(1):70-6. PubMed PMID: 3608112.
  115. MacKinnon, R., Morgan, J.P. (1986). Influence of the thyroid state on the calcium transient in ventricular muscle. Pflugers Arch, 407(2), 142-144. PubMed PMID: 2428004.

 

Review Articles:

  1. Gouaux, E., MacKinnon, R. (2005). Principles of selective ion transport in channels and pumps. Science, 310(5753), 1461-1465. PubMed PMID: 16322449.
  2. MacKinnon, R. (2005). Membrane protein insertion and stability. Science, 307(5714), 1425-1426. PubMed PMID: 15746418.
  3. MacKinnon, R. (2004). Voltage sensor meets lipid membrane. Science, 306(5700), 1304-1305. PubMed PMID: 15550651.
  4. MacKinnon, R. (2004). Potassium channels and the atomic basis of selective ion conduction (Nobel Lecture). Angew Chem Int Ed Engl, 43(33), 4265-4277. PubMed PMID: 15368373.
  5. MacKinnon, R. (2003). Potassium channels. FEBS Letter 555(1), 62-65. PubMed PMID: 14630320.
  6. MacKinnon, R. (1995). Pore loops: an emerging theme in ion channel structure. Neuron, May; 14(5):889-92. PMID: 7538310.
Touhara, K.K., Wang, W., MacKinnon, R. (2016). The GIRK1 subunit potentiates G protein activation of cardiac GIRK1/4 hetero-tetramers. eLife, 2016 Apr 13;5. pii: e15750. doi: 10.7554/eLife.15750. [E