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April 22, 2010 | awards

Ralph M. Steinman receives 2010 Heineken Prize for Medicine

Rockefeller immunologist Ralph M. Steinman receives Dutch prize for his discovery of the dendritic cell and its role in the immune response.

April 24, 2009 | awards

Ralph Steinman awarded 2009 Albany Medical Center Prize

Ralph M. Steinman, head of Rockefeller University's Laboratory of Cellular Physiology and Immunology, was named a recipient of this year's Albany Medical Center Prize in Medicine and Biomedical Research, at $500,000 the largest award in medicine or science in the United States. Steinman, recognized for his pathbreaking discoveries about the innate immune system, shares the prize with Charles A. Dinarello of the University of Colorado School of Medicine and Bruce Beutler of The Scripps Research Institute.

May 16, 2008 | science news

DNA vaccines get a boost from dendritic cells

The concept sounds ideal: vaccines made of DNA that could be taken in by other cells and give instructions for how to fight off different diseases. The reality, however, has fallen short. Although DNA vaccines have been around for about 15 years and shown lots of promise for HIV, SARS and influenza vaccines during preclinical testing in mice, researchers have yet to make them potent enough to be helpful in humans. Now, Rockefeller University researchers believe they may have a fix: targeting HIV antibody proteins directly to the coordinating cells of the immune system.

February 12, 2008 | science news

Experimental HIV vaccine gets a boost from '70s-era discovery

Although science is known for being a forward-looking field, researchers have found that they can often benefit from a glance over their shoulders. By combining an experimental AIDS vaccine with a long-neglected molecule called poly-IC, Rockefeller University scientists discovered that they were able to significantly improve its effectiveness.

January 9, 2008 | science news

Altering the balance of immune-cell receptors could help treat cancer and autoimmune diseases

Dendritic cells are responsible for directing the body's immune response, and they're activated through receptors on their surfaces. Now, in research that may have implications for novel disease therapies, Rockefeller University scientists have shown that the balance of two different versions of these Fcγ receptors - activating versus inhibitory - appears to affect production of an important set of genes, called interferon-response genes, including one believed to play an important role in autoimmunity and cancer.

September 15, 2007 | awards

Rockefeller immunologist receives Lasker Award for Basic Medical Research

This year's Albert Lasker Award for Basic Medical Research, the most prestigious American prize in science, honors Rockefeller University's Ralph M. Steinman, who discovered dendritic cells, the preeminent component of the immune system that initiates and regulates the body's response to foreign antigens.

April 11, 2007 | science news

Dendritic cells may be key to reversing diabetes

Type 1 diabetes occurs when the body's own immune system assaults the cells responsible for producing insulin. Now, researchers studying the immune system's dendritic cells have found a way to stop the destruction and help revive and maintain the population of insulin-producing ß cells in mice, a discovery that could lead to a lasting cure.

January 25, 2007 | science news

Dendritic cell receptor may be the key to an HIV vaccine

Recent attempts to develop a vaccine have elicited only limited action from two immune system cells, helper T cells and killer T cells. But Rockefeller University scientists working on a new approach have evidence that targeting a third group of immune cells, dendritic cells, may be even more effective than they'd previously believed. Now new research shows that the dendritic cells' DEC-205 receptor may be the key to making it work.

August 8, 2006 | grants and gifts

Rockefeller researchers receive Gates Foundation grant for HIV vaccine research

David Ho has received $24.7 million to lead a consortium of Rockefeller University investigators on a project that will attempt to design HIV vaccine candidates that specifically target dendritic cells.

March 7, 2006 | science news

By targeting dendritic cells, HIV and malarial vaccines outperform competitors

In two papers published this month in the Journal of Experimental Medicine, Ralph Steinman, Henry G. Kunkel Professor and head of the Laboratory of Cellular Physiology and Immunology, Michel Nussenzweig, Sherman Fairchild Professor and head of the Laboratory of Molecular Immunology, and their colleagues show that they can target dendritic cells of living animals and induce specific defenses against malaria and HIV that appear to outperform current methods.

June 27, 2005 | grants and gifts

Dr. Steinman awarded a grant from the Grand Challenges in Global Health Initiative

Dr. Steinman's team plans to develop vaccines that stimulate the immune system's dendritic cells, which are known to play an important role in stimulating protection against infectious diseases.

June 7, 2004 | science news

Lab mice rescued from Type 1 diabetes via dendritic cell-assisted therapy

Rockefeller University researchers have for the first time demonstrated a halting of early Type 1 diabetes in mice by restoring a critical class of T cells to their normal balance. The findings prove an important biological principle that could lead to prevention of Type 1 diabetes in humans: autoimmunity can be reversed if the immune system's mechanisms for tolerance -- recognition and acceptance of the body's own cells -- can be repaired.

April 8, 2003 | awards

Rockefeller University immunologist Ralph M. Steinman receives 2003 Gairdner International Award

Ralph M. Steinman, M.D., Henry G. Kunkel Professor at The Rockefeller University and a senior physician at The Rockefeller University Hospital, has received the 2003 Gairdner International Award. Steinman, a cell biologist whose research focuses on the immune system, including the human immune system in the setting of several diseases, heads the Laboratory of Cellular Physiology and Immunology at Rockefeller.

Winter 2003 | interviews

A Conversation with . . .

Last month, Ralph M. Steinman, the Henry G. Kunkel Professor and head of the Laboratory of Cellular Physiology and Immunology, was elected a member of the Institute of Medicine, joining 13 fellow Rockefeller faculty who serve on this select group.

July 14, 1999 | science news

Rockefeller Researchers Inject Cells, Boost Immune System in Humans

A single injection of specialized immune system cells­removed from the bloodstream and exposed to a foreign substance­can trigger a potent immune response in humans that lasts for months, Rockefeller University researchers report. The experiment provides the first conclusive evidence that one dose of these cells, called dendritic cells, can prompt a strong immune response, and it suggests new ways of improving vaccines and protecting against cancer.