Selected Publications

2023 to present

  1. Yuan S, Stewart KS, Yang Y, Abdusselamoglu MD, Parigi SM, Feinberg TY, Tumaneng K, Yang H, Levorse JM, Polak L, Ng D, Fuchs E. "Ras drives malignancy through stem cell crosstalk with the microenvironment." Nature DOI: 10.1038/s41586-022-05475-6 (2022).
  2. Hurwitz B, Guzzi N, Gola A, Fiore VF, Sendoel A, Nikolova M, Barrows D, Carroll TS, Pasolli HA, Fuchs E. "The integrated stress response remodels the microtubule-organizing center to clear unfolded proteins following proteotoxic stress." Elife 11:e77780 DOI: 10.7554/eLife.77780 (2022).
  3. Naik S, Fuchs E. "Inflammatory memory and tissue adaptation in sickness and in health." Nature 607(7918):249-255 DOI: 607(7918):249-255 (2022).
  4. Niec RE, Chu T, Schernthanner M, Gur-Cohen S, Hidalgo L, Pasolli HA, Luckett KA, Wang Z, Bhalla SR, Cambuli F, Kataru RP, Ganesh K, Mehrara BJ, Pe'er D, Fuchs E. "Lymphatics act as a signaling hub to regulate intestinal stem cell activity." Cell Stem Cell 29(7):1067-1082.e18. DOI: 10.1016/j.stem.2022.05.007 (2022).
  5. Niec RE, Rudensky AY, Fuchs E."Inflammatory adaptation in barrier tissues." Cell 184(13):3361-3375. DOI: 10.1016/j.cell.2021.05.036 (2021).
  6. Gonzales KAU, Polak L, Matos I, Tierney MT, Gola A, Wong E, Infarinato NR, Nikolova M, Luo S, Liu S, Novak JSS, Lay K, Pasolli HA, Fuchs E. "Stem cells expand potency and alter tissue fitness by accumulating diverse epigenetic memories." Science 374(6571). DOI: 10.1126/science.abh2444 (2021).
  7. Larsen SB, Cowley CJ, Sajjath SM, Barrows D, Yang Y, Carroll TS, Fuchs E. "Establishment, maintenance, and recall of inflammatory memory." Cell Stem Cell. doi: 10.1016/j.stem.2021.07.001. (2021).

 

2016 to 2020

  1. Infarinato NR, Stewart KS, Yang Y, Gomez NC, Pasolli HA, Hidalgo L, Polak L, Carroll TS, Fuchs E.”BMP signaling: at the gate between activated melanocyte stem cells and differentiation.” Genes Dev DOI: 10.1101/gad.340281.120 [Epub ahead of print] (2020).
  2. Fiore VF, Krajnc M, Quiroz FG, Levorse J, Pasolli HA, Shvartsman SY, Fuchs E.”Mechanics of a multilayer epithelium instruct tumour architecture and function.” Nature DOI: 10.1038/s41586-020-2695-9 [Epub ahead of print] (2020).
  3. Xi L, Carroll T, Matos I, Luo JD, Polak L, Pasolli HA, Brüning JC, Jaffrey SR, Fuchs E. ”m6A RNA methylation impacts fate choices during skin morphogenesis.” eLife DOI: 10.7554/eLife.56980 [Epub ahead of print] (2020).
  4. Baksh SC, Todorova PK, Gur-Cohen S, Hurwitz B, Ge Y, Novak JSS, Tierney MT, Dela Cruz-Racelis J, Fuchs E, Finley LWS. ”Extracellular serine controls epidermal stem cell fate and tumour initiation.” Nat Cell Biol DOI: 10.1038/s41556-020-0525-9 [Epub ahead of print] (2020).
  5. Adam RC, Yang H, Ge Y, Infarinato NR, Gur-Cohen S, Miao Y, Wang P, Zhao Y, Lu CP, Kim JE, Ko JY, Paik SS, Gronostajski RM, Kim J, Krueger JG, Zheng D, Fuchs E. ” NFI transcription factors provide chromatin access to maintain stem cell identity while preventing unintended lineage fate choices.” Nat Cell Biol DOI: 10.1038/s41556-020-0513-0 [Epub ahead of print] (2020).
  6. Matos I, Asare A, Levorse J, Ouspenskaia T, de la Cruz-Racelis J, Schuhmacher LN, Fuchs E. ” Progenitors oppositely polarize WNT activators and inhibitors to orchestrate tissue development.” eLife DOI: 10.7554/eLife.54304 (2020).
  7. Garcia Quiroz, F, Fiore VF, Levorse J, Polak L, Wong E, Pasolli HA, Fuchs E.” Liquid-liquid phase separation drives skin barrier formation.” Science 367(6483) (2020).
  8. Ge Y, Miao Y, Gur-Cohen S, Gomez N, Yang H, Nikolova M, Polak L, Hu Y, Verma A, Elemento O, Krueger JG, Fuchs E. “The aging skin microenvironment dictates stem cell behavior.” Proc Natl Acad Sci U S A. 117(10):5339-5350 (2020).
  9. Larsen SB, Cowley CJ, Fuchs E.“Epithelial cells: liaisons of immunity.” Curr Opin Immunol 62:45-53. DOI: 10.1016/j.coi.2019.11.004 (2019).
  10. Gur-Cohen S, Yang H, Baksh SC, Miao Y, Levorse L, Kataru RP, Liu X, de la Cruz-Racelis J, Mehrara BJ, Fuchs E. “Stem cell–driven lymphatic remodeling coordinates tissue regeneration.” Science DOI: 10.1126/science.aay4509 (2019).
  11. Laurin M, Gomez NC, Levorse J, Sendoel A, Sribour M, Fuchs EF. “An RNAi screen unravels the complexities of Rho GTPase networks in skin morphogenesis.” eLIFE DOI: 10.7554/eLife.50226 (2019).

  12. Ellis SJ, Gomez NC, Levorse J, Mertz AF, Ge Y, Fuchs E. “Distinct modes of cell competition shape mammalian tissue morphogenesis.” Nature 569(7757):497-502 (2019).

  13. 13. Miao Y, Yang H, Levorse J, Yuan S, Polak L, Sribour M, Singh B, Rosenblum MD, Fuchs E. “Adaptive Immune Resistance Emerges from Tumor-Initiating Stem Cells.”Cell 177(5):1172-1186 (2018).

  14. Lay K, Yuan S, Gur-Cohen S, Miao Y, Han T, Naik S, Pasolli HA, Larsen SB, Fuchs E. "Stem cells repurpose proliferation to contain a breach in their niche barrier."eLife DOI: 10.7554/eLife.41661 (2018).

  15. Naik S, Larsen SB, Cowley CJ, Fuchs E. "Two to Tango: Dialog between Immunity and Stem Cells in Health and Disease." Cell 175(4):908-920 (2018).

  16. Ge Y, Fuchs E. "Stretching the limits: from homeostasis to stem cell plasticity in wound healing and cancer." Nat Rev Genet 19(5):311-325  (2018).

  17. Adam RC, Yang H, Ge Y, Lien WH, Wang P, Zhao Y, Polak L, Levorse J, Baksh SC, Zheng D, Fuchs E. “Temporal Layering of Signaling Effectors Drives Chromatin Remodeling during Hair Follicle Stem Cell Lineage Progression.” Cell Stem Cell 22(3):398-413;(2018) .

  18. Gonzales KAU, Fuchs E. “Skin and Its Regenerative Powers: An Alliance between Stem Cells and Their Niche.” Dev Cell 43(4):387-401 (2017).

  19. 19. Naik S, Larsen SB, Gomez NC, Alaverdyan K, Sendoel A, Yuan S, Polak L, Kulukian A, Chai S, Fuchs E. "Inflammatory memory sensitizes skin epithelial stem cells to tissue damage." Nature 550: 475–480 (2017).

  20. Ge Y, Gomez NC, Adam RC, Nikolova M, Yang H, Verma A, Lu CP, Polak L, Yuan S, Elemento O, Fuchs E. "Stem Cell Lineage Infidelity Drives Wound Repair and Cancer." Cell 169:1-15 (2017).

  21. Yang H, Adam RC, Ge Y, Hua ZL, Fuchs E. Cell Epithelial-Mesenchymal Micro-niches Govern Stem Cell Lineage Choices. Cell 169(3):483-496 (2017).

  22. Asare A, Levorse J, Fuchs E. “Coupling organelle inheritance with mitosis to balance growth and differentiation.” Science 355(6324) (2017).

  23. Sendoel A, Dunn JG, Rodriguez EH, Naik S, Gomez NC, Hurwitz B, Levorse J, Dill BD, Schramek D, Molina H, Weissman JS, Fuchs E. “Translation from unconventional 5' start sites drives tumour initiation.” Nature 541:494–499 (2017).

  24. Lu CP, Polak L, Keyes BE, Fuchs E. “Spatiotemporal antagonism in mesenchymal-epithelial signaling in sweat versus hair fate decision.”  Science 354(6319) doi: 10.1126/science.aah6102 (2016).

  25. Keyes BE, Liu S, Asare A, Naik S, Levorse J, Polak L, Lu CP, Nikolova M, Pasolli HA, Fuchs E. “Impaired Epidermal to Dendritic T Cell Signaling Slows Wound Repair in Aged Skin.” Cell 167(5):1323-1338 (2016).

  26. Ezratty EJ, Pasolli HA, Fuchs E. “A Presenilin-2-ARF4 trafficking axis modulates Notch signaling during epidermal differentiation.” J Cell Biol 214(1):89-101 (2016).  

  27. Lay K, Kume T, Fuchs E. “FOXC1 maintains the hair follicle stem cell niche and governs stem cell quiescence to preserve long-term tissue-regenerating potential.” Proc Natl Acad Sci U S A 113(11):E1506-15 (2016). 

  28. Ouspenskaia T, Matos I, Mertz AF, Fiore VF, Fuchs E. “WNT-SHH Antagonism Specifies and Expands Stem Cells prior to Niche Formation.” Cell 164(1-2):156-69 (2016).

  29. Adam RC, Fuchs E. “The Yin and Yang of Chromatin Dynamics In Stem Cell Fate Selection.” Trends Genet 32(2):89-100 (2016).

 

 

2011 to 2015

 

  1. Ge Y, Zhang L, Nikolova M, Reva B, Fuchs E. “Strand-specific in vivo screen of cancer-associated miRNAs unveils a role for miR-21∗ in SCC progression.  Nat Cell Biol 18(1):111-21 (2015).

  2. Yang H, Schramek D, Adam RC, Keyes BE, Wang P, Zheng D, Fuchs E. “ETS family transcriptional regulators drive chromatin dynamics and malignancy in squamous cell carcinomas.”Elife doi: 10.7554/eLife.10870 (2015).

  3. Kulukian A, Holland AJ, Vitre B, Naik S, Cleveland DW, Fuchs E. “Epidermal development, growth control, and homeostasis in the face of centrosome amplification.” Proc Natl Acad Sci U S A 112(46):E6311-E6320 (2015).

  4. Fuchs E. An unconventional route to becoming a cell biologist. Mol Biol Cell 26(21):3697-9 (2015).

  5. Heller E, Fuchs E. "Tissue patterning and cellular mechanics. J Cell Biol 211(2):219-31. (2015).

  6. Fuchs E. "Cell biology: More than skin deep."  J Cell Biol 209(5):629-31 (2015).

  7. Luxenburg C, Heller E, Pasolli HA, Chai S, Nikolova M, Stokes N, Fuchs E.  “Wdr1-mediated cell shape dynamics and cortical tension are essential for epidermal planar cell polarity.” Nat Cell Biol 17(5):592-604 (2015).

  8. Adam R.C., Yang H, Rockowitz S, Larsen S.B, Nikolova M, Oristian D.S, Polak L, Kadaja M, Asare A, Zheng D, Fuchs E. “Pioneer factors govern super-enhancer dynamics in stem cell plasticity and lineage choice.” Nature 521(7552):366-70 (2015).

  9. Oshimori N, Oristian D, Fuchs E. “TGF-β Promotes Heterogeneity and Drug Resistance in Squamous Cell Carcinoma.” Cell 160(5):963-76 (2015).

  10. Zhang L, Ge Y, Fuchs E.  “miR-125b can enhance skin tumor initiation and promote malignant progression by repressing differentiation and prolonging cell survival.”  Genes Dev 28(22):2532-46 (2014). 

  11. Genander M, Cook PJ, Ramsköld D, Keyes BE, Mertz AF, Sandberg R, Fuchs E.  “BMP Signaling and Its pSMAD1/5 Target Genes Differentially Regulate Hair Follicle Stem Cell Lineages.”  Cell Stem Cell 15(5):619-33 (2014). 

  12. Hsu YC, Li L, Fuchs E.  “Emerging interactions between skin stem cells and their niches.”  Nat Med 20(8):847-56 (2014).

  13. Lien WH, Fuchs E.  “Wnt some lose some: transcriptional governance of stem cells by Wnt/β-catenin signaling.”  Genes Dev 28(14):1517-1532 (2014).

  14. Williams SE, Ratliff LA, Postiglione MP, Knoblich JA, Fuchs E.  “Par3-mInsc and Gαi3 cooperate to promote oriented epidermal cell divisions through LGN.”  Nat Cell Biol 16(8):758-69 (2014).

  15. Blanpain C, Fuchs E.  “Stem cell plasticity. Plasticity of epithelial stem cells in tissue regeneration.”  Science 344(6189) (2014).

  16. Hsu YC, Li L, Fuchs E.  “Transit-amplifying cells orchestrate stem cell activity and tissue regeneration.”  Cell 157(4):935-49 (2014). 

  17. Heller E, Kumar KV, Grill SW, Fuchs E.  Forces generated by cell intercalation tow epidermal sheets in Mammalian tissue morphogenesis.  Dev Cell 28(6):617-32 (2014).

  18. Kadaja M, Keyes BE, Lin M, Pasolli HA, Genander M, Polak L, Stokes N, Zheng D, Fuchs E.  “SOX9: a stem cell transcriptional regulator of secreted niche signaling factors.”  Genes Dev 28(4):328-41 (2014).

  19. Lu C, Fuchs E.  “Sweat gland progenitors in development, homeostasis, and wound repair.”  Cold Spring Harb Perspect Med 4(2) (2014).

  20. Lien WH, Polak L, Lin M, Lay K, Zheng D, Fuchs E.  “In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators.”  Nat Cell Biol 16(2):179-90 (2014).

  21. Schramek D, Sendoel A, Segal JP, Beronja S, Heller E, Oristian D, Reva B, Fuchs E.  “Direct in vivo RNAi screen unveils myosin IIa as a tumor suppressor of squamous cell carcinomas.”  Science 343(6168):309-13 (2014).

  22. Keyes BE, Segal JP, Heller E, Lien WH, Chang CY, Guo X, Oristian DS, Zheng D, Fuchs E.  “Nfatc1 orchestrates aging in hair follicle stem cells.”  Proc Natl Acad Sci U S A 110(51):E4950-9 (2013).

  23. Kulukian A, Fuchs E.  ‘Spindle orientation and epidermal morphogenesis.”  Philos Trans R Soc Lond B Biol Sci 368(1629):20130016 (2013).

  24. Folgueras AR, Guo X, Pasolli HA, Stokes N, Polak L, Zheng D, Fuchs E.  “Architectural Niche Organization by LHX2 Is Linked to Hair Follicle Stem Cell Function.”  Cell Stem Cell 13(3):314-27 (2013).

  25. Beronja S, Janki P, Heller E, Lien WH, Keyes BE, Oshimori N, Fuchs E. “RNAi screens in mice identify physiological regulators of oncogenic growth.”  Nature 501(7466):185-90 (2013).

  26. Chang CY, Pasolli HA, Giannopoulou EG, Guasch G, Gronostajski RM, Elemento O, Fuchs E.  “NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared niche.”  Nature 495(7439):98-102 (2013). 

  27. Beronja S, Fuchs E.  “RNAi-mediated gene function analysis in skin.”  Methods Mol Biol 961:351-61 (2013).

  28. Fuchs E, Chen T.  “A matter of life and death: self-renewal in stem cells.” EMBO Rep 14(1):39-48 (2013).

  29. Oshimori N, Fuchs E.  “The Harmonies Played by TGF-β in Stem Cell Biology. “  Cell Stem Cell 11(6):751-64 (2012).

  30. Lu CP, Polak L, Rocha AS, Pasolli HA, Chen SC, Sharma N, Blanpain C, Fuchs E.  “Sweat glands grown from newly identified stem cells.”  Cell 150(1):136-150 (2012).

  31. Fuchs E.  “Cédric Blanpain: ISSCR's Outstanding Young Investigator for 2012.”  Cell Stem Cell 10(6):751-2 (2012).

  32. Fuchs E.  “The impact of cell culture on stem cell research.”  Cell Stem Cell 10(6):640-1 (2012).

  33. Suozzi KC, Wu X, Fuchs E.  “Spectraplakins: Master orchestrators of cytoskeletal dynamics.”  J Cell Biol 197(4):465-75 (2012).

  34. Chen T, Heller E, Beronja S, Oshimori N, Stokes N, Fuchs E.  “An RNA interference screen uncovers a new molecule in stem cell self-renewal and long-term regeneration.”  Nature 485(7396):104-8 (2012).

  35. Livshits G, Kobielak A, Fuchs E.  Governing epidermal homeostasis by coupling cell-cell adhesion to integrin and growth factor signaling, proliferation, and apoptosis.  Proc Natl Acad Sci U S A 109(13):4886-91 (2012).

  36. Hsu YC, Fuchs E.  “A family business: stem cell progeny join the niche to regulate homeostasis.” Nat Rev Mol Cell Biol 13(2):103-14 (2012).

  37. Oshimori N, Fuchs E.  “Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation.” Cell Stem Cell 10(1):63-75 (2012).

  38. Beronja S, Fuchs E.  A breath of fresh air in lung regeneration.  Cell 147(3):485-7 (2011).

  39. Lien WH, Guo X, Polak L, Lawton LN, Young RA, Zheng D, Fuchs E. "Genome-wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage." Cell Stem Cell 9(3):219-32 (2011) .

  40. Devenport D, Oristian D, Heller E, Fuchs E. "Mitotic internalization of planar cell polarity proteins preserves tissue polarity." Nat Cell Biol 13(8):893-902 (2011).

  41. Ezratty EJ, Stokes N, Chai S, Shah AS, Williams SE, Fuchs E. "A role for the primary cilium in Notch signaling and epidermal differentiation during skin development." Cell 145(7):1129-41 (2011).

  42. Schober M, Fuchs E. "Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF-β and integrin/focal adhesion kinase (FAK) signaling." Proc Natl Acad Sci U S A 108(26):10544-9 (2011).

  43. Fuchs E. "Reflections of an ISSCR president, 2010-2011." Cell Stem Cell 8(6):629-30 (2011).

  44. Fuchs E, Horsley V. "Ferreting out stem cells from their niches." Nat Cell Biol 13(5):513-8 (2011).

  45. Kaneko H, Dridi S, Tarallo V, Gelfand BD, Fowler BJ, Cho WG, Kleinman ME, Ponicsan SL, Hauswirth WW, Chiodo VA, Karikó K, Yoo JW, Lee DK, Hadziahmetovic M, Song Y, Misra S, Chaudhuri G, Buaas FW, Braun RE, Hinton DR, Zhang Q, Grossniklaus HE, Provis JM, Madigan MC, Milam AH, Justice NL, Albuquerque RJ, Blandford AD, Bogdanovich S, Hirano Y, Witta J, Fuchs E, Littman DR, Ambati BK, Rudin CM, Chong MM, Provost P, Kugel JF, Goodrich JA, Dunaief JL, Baffi JZ, Ambati J. "DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration." Nature 471 (7338):325-30 (2011).

  46. Zhang L, Stokes N, Polak L, Fuchs E. "Specific MicroRNAs Are Preferentially Expressed by Skin Stem Cells To Balance Self-Renewal and Early Lineage Commitment." Cell Stem Cell 8(3):294-308 (2011).

  47. Luxenburg C, Amalia Pasolli H, Williams SE, Fuchs E. "Developmental roles for Srf, cortical cytoskeleton and cell shape in epidermal spindle orientation." Nat Cell Biol 13(3):203-14 (2011).

  48. Williams SE, Beronja S, Pasolli HA, Fuchs E. "Asymmetric cell divisions promote Notch-dependent epidermal differentiation." Nature 470(7334):353-8 (2011).

  49. Ezhkova E, Lien WH, Stokes N, Pasolli HA, Silva JM, Fuchs E. "EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair." Genes Dev 25(5):485-98 (2011).

  50. Wu X, Shen QT, Oristian DS, Lu CP, Zheng Q, Wang HW, Fuchs E. "Skin Stem Cells Orchestrate Directional Migration by Regulating Microtubule-ACF7 Connections through GSK3β." Cell 144(3):341-52 (2011).

  51. Zhang H, Pasolli HA, Fuchs E. "Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin." Proc Natl Acad Sci U S A 108(6):2270-5 (2011).

  52. Zaidi MR, Davis S, Noonan FP, Graff-Cherry C, Hawley TS, Walker RL, Feigenbaum L, Fuchs E, Lyakh L, Young HA, Hornyak TJ, Arnheiter H, Trinchieri G, Meltzer PS, De Fabo EC, Merlino G. "Interferon-? links ultraviolet radiation to melanomagenesis in mice." Nature 469(7331):548-53 (2011).

  53. Hsu YC, Pasolli HA, Fuchs E. "Dynamics between stem cells, niche, and progeny in the hair follicle." Cell 144(1):92-105 (2011).

 

2006 to 2010

  1. Seidel K, Ahn CP, Lyons D, Nee A, Ting K, Brownell I, Cao T, Carano RA, Curran T, Schober M, Fuchs E, Joyner A, Martin GR, de Sauvage FJ, Klein OD. "Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor. Development 137(22):3753-61 (2010).
  2. Fuchs E. "Toward a knowledge of causes." Cell Stem Cell 7(3):315-7 (2010).
  3. Ezhkova E, Fuchs E."Regenerative medicine: An eye to treating blindness." Nature 466(7306):567-8 (2010).
  4. Beronja S, Livshits G, Williams S, Fuchs E. "Rapid functional dissection of genetic networks via tissue-specific transduction and RNAi in mouse embryos." Nat Med 16(7):821-7 (2010).
  5. Nguyen H, Merrill BJ, Polak L, Nikolova M, Rendl M, Shaver TM, Pasolli HA, Fuchs E. "Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia." Nat Genet 41(10):1068-1075 (2009).
  6. Coulombe PA, Kerns ML, Fuchs E. "Epidermolysis bullosa simplex: a paradigm for disorders of tissue fragility." J Clin Invest 119(7):1784-93 (2009).
  7. Fuchs E. "Building confidence:the transition from student to professor." Nat Cell Biol 11(7):786 (2009).
  8. Silva JM, Ezhkova E, Silva J, Heart S, Castillo M, Campos Y, Castro V, Bonilla F, Cordon-Cardo C, Muthuswamy SK, Powers S, Fuchs E, Hannon GJ. "Cyfip1 is a putative invasion suppressor in epithelial cancers." Cell 137(6):1047-61 (2009).
  9. Fuchs E. "Finding one's niche in the skin." Cell Stem Cell 4(6):499-502 (2009).
  10. Fuchs E. "The tortoise and the hair: slow-cycling cells in the stem cell race." Cell 137(5):811-9 (2009).
  11. Ezhkova E, Pasolli HA, Parker JS, Stokes N, Su IH, Hannon G, Tarakhovsky A, Fuchs E. "Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells." Cell 136(6):1122-35 (2009).
  12. Blanpain C, Fuchs E. "Epidermal homeostasis: a balancing act of stem cells in the skin." Nat Rev Mol Cell Biol 10(3):207-17 (2009).
  13. Greco V, Chen T, Rendl M, Schober M, Pasolli HA, Stokes N, Dela Cruz-Racelis J, Fuchs E. "A two-step mechanism for stem cell activation during hair regeneration." Cell Stem Cell 4(2):155-69 (2009).
  14. Yi R, Pasolli HA, Landthaler M, Hafner M, Ojo T, Sheridan R, Sander C, O'Carroll D, Stoffel M, Tuschl T, Fuchs E. "DGCR8-dependent microRNA biogenesis is essential for skin development." Proc Natl Acad Sci U S A 106(2):498-502 (2009).
  15. Nowak JA, Fuchs E. "Isolation and culture of epithelial stem cells." Methods Mol Biol 482:215-32 (2009)
  16. Fuchs E, Nowak JA. "Building Epithelial Tissues from Skin Stem Cells." Cold Spring Harb Symp Quant Biol (2008).
  17. Wu X, Kodama A, Fuchs E. "ACF7 regulates cytoskeletal-focal adhesion dynamics and migration and has ATPase activity." Cell 135(1):137-48 (2008).
  18. Devenport D, Fuchs E. "Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair follicles." Nat Cell Biol 10(11):1257-68 (2008).
  19. Wang X, Pasolli HA, Williams T, Fuchs E. "AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis." J Cell Biol 183(1):37-48 (2008).
  20. Tinkle CL, Pasolli HA, Stokes N, Fuchs E. "New insights into cadherin function in epidermal sheet formation and maintenance of tissue integrity." Proc Natl Acad Sci USA 105(40):15405-10 (2008).
  21. Perez-Moreno M, Song W, Pasolli HA, Williams SE, Fuchs E. "Loss of p120 catenin and links to mitotic alterations, inflammation, and skin cancer." Proc Natl Acad Sci USA 105(40):15399-404 (2008).
  22. Nowak JA, Polak L, Pasolli HA, Fuchs E. "Hair follicle stem cells are specified and function in early skin morphogenesis." Cell Stem Cell. 3(1):33-43 (2008).
  23. Fuchs E, Horsley V. "More than one way to skin . . ." Genes Dev 22(8): 976-85 (2008).
  24. Yi R, Poy MN, Stoffel M, Fuchs E. "A skin microRNA promotes differentiation by repressing ’stemness’." Nature 452(7184): 225-9 (2008).
  25. Rendl M, Polak L, Fuchs E. "BMP signaling in dermal papilla cells is required for their hair follicle-inductive properties." Genes Dev 22(4): 543-57 (2008).
  26. Fuchs E. "Skin stem cells: rising to the surface." J Cell Biol 180(2): 273-84 (2008).
  27. Horsley V, Aliprantis AO, Polak L, Glimcher LH, and Fuchs E. "NFATc1 Balances Quiescence and Proliferation of Skin Stem Cells." Cell 132: 299-310, (2008).
  28. Guasch G, Schober M, Pasolli HA, Conn EB, Polak L, Fuchs E. "Loss of TGFbeta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia." Cancer Cell. 12(4):313-27 (2007).
  29. Kobielak K, Stokes N, de la Cruz J, Polak L, Fuchs E. "Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling." Proc Natl Acad Sci U S A 104(24):10063-10068 (2007).
  30. Schober M, Raghavan S, Nikolova M, Polak L, Pasolli HA, Beggs HE, Reichardt LF, Fuchs E. "Focal adhesion kinase modulates tension signaling to control actin and focal adhesion dynamics." J Cell Biol 176: 667-680 (2007).
  31. Fuchs E. "Scratching the surface of skin development." Nature 445: 834-842 (2007).
  32. Li J, Greco V, Guasch G, Fuchs E, Mombaerts P. "Mice cloned from skin cells." Proc Natl Acad Sci U S A 104: 2738-2743 (2007).
  33. Blanpain C, Horsley V, Fuchs E. "Epithelial Stem Cells: Turning over New Leaves." Cell 128: 445-58 (2007).
  34. Lechler T, Fuchs E. "Desmoplakin: an unexpected regulator of microtubule organization in the epidermis." J Cell Biol 176: 147-54 (2007).
  35. Blanpain C, Lowry WE, Pasolli HA, Fuchs E. "Canonical notch signaling functions as a commitment switch in the epidermal lineage." Genes Dev 20: 3022-35 (2006).
  36. Perez-Moreno M and Fuchs E. "Catenins: Keeping cells from getting their signals crossed." Dev Cell 11: 601-612 (2006).
  37. Nguyen H, Rendl M, Fuchs E. "Tcf3 governs stem cell features and represses cell fate determination in the skin." Cell 127: 171-183 (2006).
  38. Horsley V, O'Carroll D, Tooze R, Ohinata Y, Saitou M, Obukhanych T, Nussenzweig M, Tarakhovsky A, and Fuchs E. "Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland." Cell 126(3):597-609 (2006).
  39. Blanpain C and Fuchs E. "Epidermal Stem Cells of the Skin." Annu Rev Cell Dev Biol 22: 339-73 (2006).
  40. Rhee H, Polak L, and Fuchs E. "Lhx2 maintains stem cell character in hair follicles." Science 312:1946-9 (2006).
  41. Kobielak A and Fuchs E. "Links between alpha-catenin, NF-kappaB, and squamous cell carcinoma in skin." Proc Natl Acad Sci U S A 103: 2322-7 (2006).
  42. Perez-Moreno M., Davis MA, Wong E, Pasolli HA, Reynolds AB, and Fuchs E. "p120-catenin mediates inflammatory responses in the skin." Cell 124: 631-44 (2006).
  43. Yi R, O'Carroll D, Pasolli HA, Zhang Z, Dietrich FS, Tarakhovsky A, and Fuchs E. "Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs." Nat Genet 38: 356-62 (2006).
  44. Wang X, Bolotin D, Chu DH, Polak L, Williams T, and Fuchs E. "AP-2alpha: a regulator of EGF receptor signaling and proliferation in skin epidermis." J Cell Biol 172(3): 409-21 (2006).

 

2000 to 2005

  1. Guasch G and Fuchs E. "Mice in the world of stem cell biology." Nat Genet 37: 1201-6 (2005).
  2. Rendl M, Lewis L, and Fuchs E. "Molecular dissection of mesenchymal-epithelial interactions in the hair follicle." PLoS Biol 3: 1910-23 (2005).
  3. Lechler T and Fuchs E. "Asymmetric cell divisions promote stratification and differentiation of mammalian skin." Nature 437: 275-280 (2005).
  4. Alonso L, Okada H, Pasolli HA, Wakeham A, You-Ten AI, Mak TW, Fuchs E. "Sgk3 links growth factor signaling to maintenance of progenitor cells in the hair follicle." J Cell Biol 170: 559-70 (2005).
  5. Lowry WE, Blanpain C, Nowak JA, Guasch G, Lewis L, Fuchs E. "Defining the impact of beta-catenin/Tcf transactivation on epithelial stem cells." Genes Dev 19: 1596-1611 (2005).
  6. Jamora C, Lee P, Kocieniewski P, Azhar M, Hosokawa R, Chai Y, Fuchs E. "A signaling pathway involving TGF-beta2 and snail in hair follicle morphogenesis." PLoS Biol 3: 131-143 (2005).
  7. Blanpain C, Lowry WE, Geoghegan A, Polak L. and Fuchs E. "Self renewal, multipotency and the existence of two cell populations within an epithelial stem cell niche." Cell 118: 635-648 (2004).
  8. Fuchs E, Tumbar T, and Guasch G. "Socializing with the neighbors: stem cells and their niches." Cell 116: 769-778 (2004).
  9. TumbarT, Guasch G, Greco V, Blanpain C, Lowry WE, Rendl M and Fuchs E. "Defining the epithelial stem cell niche of the skin." Science 303: 359-363 (2004).
  10. Kobielak A, Pasolli HA, and Fuchs E. "Mammalian formin1 participates in adherens junctions and polymerization of linear actin cables." Nat Cell Biol 6: 21-30 (2004).
  11. Tinkle CL, Lechler T, Pasolli HA, and Fuchs E. "Conditional targeting of E-cadherin in skin: Insights into hyperproliferative and degenerative responses." Proc Natl Acad Sci U S A 101: 552-557 (2004).
  12. Merrill BJ, Pasolli HA, Polak L, Rendl M, Garcia-Garcia MJ, Anderson K, and Fuchs E. "Tcf3: A transcriptional regulator of axis induction in the early embryo." Development 131: 263-274 (2004).
  13. Kobielak K, Pasolli HA, Alonso L, Polak L, and Fuchs E. "Defining BMP functions in the hair follicle by conditional ablation of BMP Receptor IA." J Cell Biol 163: 609-624 (2003).
  14. Kodama A, Karakesisoglou I, Wong E, Polak L, and Fuchs E. "ACF7: An essential integrator of microtubule dynamics." Cell 115: 343-354 (2003).
  15. Kaufman CK, Pasolli HA, Rendl M, Bolotin D, Lim KC,Dai X, Alegre ML, and Fuchs E."GATA-3: An unexpected regulator of cell lineage determination in skin." Genes Dev 17: 2108-2122 (2003).
  16. Raghavan S, Vaezi A, and Fuchs E. "A Role for alphabeta1 integrins in focal adhesion regulation and polarized cytoskeletal dynamics." Dev Cell 5: 415-427 (2003).
  17. Jamora C, DasGupta R, Kocieniewski P, and Fuchs E. "Links between signal transduction, transcription and adhesion in epithelial bud development." Nature 422: 317-322 (2003).
  18. Bolotin D and Fuchs E. "Cancer: More than skin deep." Nature 421:594-595 (2003).
  19. Perez-Moreno M, Jamora C, and Fuchs E. "Sticky business: orchestrating cellular signals at adherens junctions." Cell 112: 535-48 (2003).
  20. Vaezi A, Bauer C, Vasioukhin V, and Fuchs E. "Actin cable dynamics and Rho/Rock orchestrate a polarized cytoskeletal architecture in assembling a stratified epithelium." Dev Cell 3: 367-381 (2002).
  21. Jamora C and Fuchs E. "Intercellular adhesion and signaling." Nat Cell Biol 4: 101-108 (2002).
  22. Merrill BJ, Gat U, DasGupta R and Fuchs E. "Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin." Genes Dev 15: 1688-1705 (2001).
  23. Vasioukhin V, Bauer C, Degenstein L, Wise B, and Fuchs E. "Hyperproliferation and defects in epithelial polarity upon conditional ablation of alpha-catenin in skin." Cell 104: 605-617 (2001).
  24. Vasioukhin V, Bowers E, Bauer C, Degenstein L, and Fuchs E. "Desmoplakin plays an essential role in epidermal sheet formation." Nat Cell Biol 3: 1076-1085 (2001).
  25. Raghavan S, Bauer C, Mundschau G, Li Q, and Fuchs E. "Conditional ablation of beta1 integrin in skin. Severe defects in epidermal proliferation, basement membrane formation, and hair follicle invagination." J Cell Biol 150: 1149-60 (2000).
  26. Vasioukhin V, Bauer C, Yin M, and Fuchs E. "Directed actin polymerization is the driving force for epithelial cell-cell adhesion." Cell 100: 209-219 (2000).

 

 

1996 to 1999

  1. Chan EF, Gat U, McNiff JM, and Fuchs, E. "A common human skin tumour is caused by activating mutations in beta-catenin." Nat Genet 21: 410-3 (1999).
  2. DasGupta R and Fuchs E. "Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation." Development 126: 4557-68 (1999).
  3. Yang Y, Bauer C, Strasser G, Wollman R, Julien JP and Fuchs E. "Integrators of the cytoskeleton that stabilize microtubules." Cell 98: 229-38 (1999).
  4. Gat U, DasGupta R, Degenstein L, and Fuchs E. "De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in Skin." Cell 95: 605-614 (1998).
  5. Fuchs E and Cleveland D. "Structural scaffolding of IFs in health and disease." Science 279: 514-519 (1998).
  6. Yang Y, Dowling J, Yu QC, Kouklis P, Cleveland DW and Fuchs E. "An essential cytoskeletal linker protein connecting actin microfilaments to intermediate filaments." Cell 86: 655-65 (1996).

 

1990 to 1995

  1. Guo L, Degenstein L, Dowling J, Yu QC, Wollmann R, Perman B and Fuchs E. "Gene targeting of BPAG1: abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration." Cell 81: 233-43 (1995).
  2. Paller AS, Syder AJ, Chan YM, Yu QC, Hutton E, Tadini G, and Fuchs E. "Genetic and clinical mosaicism in a type of epidermal nevus." N Engl J Med 331: 1408-15 (1994).
  3. Cheng J, Syder AJ, Yu Q-C, Letai A, Paller AS, and Fuchs E. "The genetic basis of EH, a disorder of differentiation-specific epidermal keratin genes." Cell 70:811-819 (1992).
  4. Coulombe PA, Hutton ME, Letai A, Hebert A, Paller AS and Fuchs E. "Point mutations in human keratin 14 genes of epidermolysis bullosa simplex patients: genetic and functional analyses." Cell 66:1301-11 (1991).
  5. Vassar R, Coulombe PA, Degenstein L, Albers K and Fuch E. "Mutant keratin expression in transgenic mice causes marked abnormalities resembling a human genetic skin disease." Cell 64: 365-80 (1991).

 

1980s

  1. Hanukoglu I and Fuchs E. "The cDNA sequence of type II cytoskeletal keratin reveals constant and variable structural domains among keratins." Cell 33:915-924 (1983).
  2. Hanukoglu I. and Fuchs E. "The cDNA sequence of a human epidermal keratin: Divergence of sequence but conservation of structure among intermediate filament proteins." Cell 31:243-52 (1982).
  3. Fuchs EV, Coppock SM, Green H and Cleveland DW. "Two distinct classes of keratin genes and their evolutionary significance." Cell 27:75-84 (1981).
  4. Fuchs E and Green H. "Regulation of differentiation of keratinocytes by vitamin A." Cell 25:617-625 (1981).
  5. Fuchs E and Green H. "Changes in keratin gene expression during terminal differentiation." Cell 19:1033-1042 (1980).

 

1970s

  1. Fuchs E and Green H. "Multiple keratins of cultured human epidermal cells are translated from different mRNA molecules." Cell 17:573-582 (1979).
  2. Fuchs E and Green H. "Expression of keratin genes in epidermis and cultured epidermal cells." Cell 15:887-897 (1978).

 

2023 to presentYuan S, Stewart KS, Yang Y, Abdusselamoglu MD, Parigi SM, Feinberg TY, Tumaneng K, Yang H, Levorse JM, Polak L, Ng D, Fuchs E. "Ras drives malignancy through stem cell crosstalk wi