Microtubule Movements Along Polarized Actin Bundles.

When actin cables are polarized, newly growing microtubules often track along the actin cables for guidance. Essential for establishing cell and tissue polarity, this tracking involves transient tethering of the microtubules to the actin cables, a feature requiring the cytoskeletal crosslinking protein ACF7 (see Kodama et al. Cell 115, 343-354, 2003). Shown is videoimaging depicting actin cables in red (RFP-actin) and the tips of growing microtubules in green (GFP-EB1). WT represents normal mouse endodermal cells; KO represents mouse endodermal cells lacking ACF7.

Microtubule Movements Along Polarized Actin Bundles.When actin cables are polarized, newly growing microtubules often track along the actin cables for guidance. Essential for establishing cell