Wound Healing Depends Upon Communications Between the Actin and Microtubule Cytoskeletons.

Like epithelial cells, endodermal cells form cell-cell junctions with their neighbors. When wounded, a culture of endodermal cells repairs the injury by polarizing their actin-microtubule cytoskeletons and migrating coordinately into the wound site. In the absence of the cytoskeletal crosslinking protein ACF7, the wound process is perturbed, and cells migrate seemingly irrespective of their neighbors. In the movie, the WT endodermal culture is followed by the KO culture.

Wound Healing Depends Upon Communications Between the Actin and Microtubule Cytoskeletons. Like epithelial cells, endodermal cells form cell-cell junctions with their neighbors. When wounded, a