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Dendritic Cell Videos

Dendritic Cells in Living Immune Organs

Courtesy of Michel Nussenzweig and colleagues


Three-dimensional reconstruction of the dendritic cells in green around a B cell follicle. The green "EYFP-CD11c+ cells" are in the subcapsular sinus above the follicle and in the T cell area below the follicle.


T cell zone dendritic cells. EYFP DCs (green) are numerous in the T cell zone of the lymph node, where they exhibit extensive probing movements but show little crawling.


Dendritic cells, here in yellow in the T cell zone. Blood vessels (red) are visualized following labeling with 66 kDa TRITC-dextran. The high endothelial venules (crossing from top left to bottom right), can be distinguished from arterioles (crossing in the perpendicular direction) based on their irregular epithelium and the shadows of slowly rolling lymphocytes. A mixture of slowly moving and sessile dendritic cells (CD11c-YFP cells) is evident. Also seen are lymphocytes (cyan) which are more compact than dendritic cells and can reach higher speeds.


Dendritic-T cell interactions 1-6 h after T cell transfer. Antigen-specific T cells (orange) move more slowly than nonspecific T cells (red) and are more frequently arrested on dendritic cells that are presenting antigen (green).


The processes of DCs (green) within a living lymph node actively probe their surrounding environment. In some of the films, red T cells are shown for comparison.


The processes of DCs (green) within a living lymph node actively probe their surrounding environment. In some of the films, red T cells are shown for comparison.


The processes of DCs (green) within a living lymph node actively probe their surrounding environment. In some of the films, red T cells are shown for comparison.


The processes of DCs (green) within a living lymph node actively probe their surrounding environment. In some of the films, red T cells are shown for comparison.


The processes of DCs (green) within a living lymph node actively probe their surrounding environment. In some of the films, red T cells are shown for comparison.