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Historical Scientific Reports

Some historical scientific reports from the Steinman Laboratory during its first twenty years of research on dendritic cells (in chronological order):

  • Steinman, R.M., and Cohn, Z.A. Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. J. Exp. Med. 137: 1142-1162, 1973.
  • Steinman, R.M., and Cohn, Z.A. Identification of a novel cell type in peripheral lymphoid organs of mice. II. Functional properties in vitro. J. Exp. Med. 139: 380-397, 1974.
  • Steinman, R.M., and Witmer, M.D. Lymphoid dendritic cells are potent stimulators of the primary mixed leukocyte reaction in mice. Proc. Natl. Acad. Sci. USA 75: 5132-5136, 1978.
  • Steinman, R.M., Kaplan, G., Witmer, M.D., and Cohn, Z.A. Identification of a novel cell-type in peripheral lymphoid organs of mice. V. Purification of spleen dendritic cells, new surface markers, and maintenance in vitro. J. Exp. Med. 149: 1-16, 1979.
  • Nussenzweig, M.C., Steinman, R.M., Gutchinov, B., and Cohn, Z.A. Dendritic cells are accessory cells for the development of anti-trinitrophenyl cytotoxic T lymphocytes. J. Exp. Med. 152: 1070-1084, 1980.
  • Steinman, R.M., Nogueira, N., Witmer, M.D., Tydings, J.D., and Mellman, I.S. Lymphokine enhances the expression and synthesis of Ia antigen on cultured mouse peritoneal macrophages. J. Exp. Med. 152: 1248-1261, 1980.
  • Nussenzweig, M.C., Steinman, R.M., Unkeless, J.C., Witmer, M.D., Gutchinov, B., and Cohn, Z.A. Studies of the cell surface of mouse dendritic cells and other leukocytes. J. Exp. Med. 154: 168-187, 1981.
  • Nussenzweig, M.C., Steinman, R.M., Witmer, M.D., and Gutchinov, B. A monoclonal antibody specific for mouse dendritic cells. Proc. Natl. Acad. Sci. USA 79: 161-165, 1982.
  • Van Voorhis, W.C., Hair, L.S., Steinman, R.M., and Kaplan, G. Human dendritic cells: Enrichment and characterization from peripheral blood. J. Exp. Med. 155: 1172-1187, 1982.
  • Steinman, R.M., Gutchinov, B., Witmer, M.D., and Nussenzweig, M.C. Dendritic cells are the principal stimulators of the primary mixed leukocyte reaction in mice. J. Exp. Med. 157: 613-627, 1983.
  • Austyn, J.M., Steinman, R.M., Weinstein, D.E., Granelli-Piperno, A., and Palladino, M.A. Dendritic cells initiate a two stage mechanism for T lymphocyte proliferation. J. Exp. Med. 157: 1101-1115, 1983.
  • Van Voorhis, W.C., Valinsky, J., Hoffman, E., Luban, J., Hair, L.S., and Steinman, R.M. The relative efficacy of human monocytes and dendritic cells as accessory cells for T cell replication. J. Exp. Med. 158: 174-191, 1983.
  • Inaba, K., Steinman, R.M., Van Voorhis, W.C., and Muramatsu, S. Dendritic cells are critical accessory cells for thymus-dependent antibody responses in mouse and in man. Proc. Natl. Acad. Sci. USA. 80: 6041-6045, 1983.
  • Faustman, D., Steinman, R.M., Gebel, H., Hauptfeld, V., Davie, J., and Lacy, P. Prevention of rejection of murine islet allografts by pretreatment with anti-dendritic cell antibody. Proc. Natl. Acad. Sci. USA. 81: 3864-3868, 1984.
  • Witmer, M.D., and Steinman, R.M. The anatomy of peripheral lymphoid organs with emphasis on accessory cells: light microscopic, immunocytochemical studies of mouse spleen, lymph node and Peyer's patch. Am. J. Anat. 170: 465-481, 1984.
  • Inaba, K., Witmer, M.D., and Steinman, R.M. Clustering of dendritic cells, helper T lymphocytes, and histocompatible B cells, during primary antibody responses in vitro. J. Exp. Med. 160: 858-876, 1984.
  • Inaba, K., and Steinman, R.M. Resting and sensitized T lymphocytes exhibit distinct stimulatory (antigen presenting cell) requirements for growth and lymphokine release. J. Exp. Med. 160: 1717-1735, 1984.
  • Schuler, G., and Steinman, R.M. Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro. J. Exp. Med. 161: 526-546, 1985.
  • Lepay, D.A., Nathan, C.F., Steinman, R.M., Murray, H.W., and Cohn, Z.A. Murine Kupffer cells: mononuclear phagocytes deficient in the generation of reactive oxygen intermediates. J. Exp. Med. 161: 1079-1096, 1985.
  • Inaba, K., and Steinman, R.M. Accessory cell - T lymphocyte interactions: antigen dependent and independent clustering. J. Exp. Med. 163: 247-261, 1986.
  • Inaba, K., Schuler, G., Witmer, M., Valinsky, J., Atassi, B., and Steinman, R.M. Immunologic properties of purified epidermal Langerhans cells: Distinct requirements for stimulation of unprimed and sensitized T lymphocytes. J. Exp. Med. 164: 605-613, 1986.
  • Inaba, K., Young, J.W., and Steinman, R.M. Direct activation of CD8+ cytotoxic T lymphocytes by dendritic cells. J. Exp. Med. 166: 182-194, 1987.
  • Witmer-Pack, M.D., Olivier, W., Valinsky, J., Schuler, G., and Steinman, R.M. Granulocyte-macrophage colony stimulating factor is essential for the viability and function of cultured murine epidermal Langerhans cells. J. Exp. Med. 166: 1484-1498, 1987.
  • Crowley, M., Inaba, K., Witmer-Pack, M., and Steinman, R.M. The cell surface of mouse dendritic cells: FACS analysis of dendritic cells from different tissues including thymus. Cell. Immunol. 118: 108-125, 1989.
  • Romani, N., Inaba, K., Puré, E., Crowley, M., Witmer-Pack, M., and Steinman, R.M. A small number of anti-CD3 molecules on dendritic cells stimulates DNA synthesis in mouse T lymphocytes. J. Exp. Med. 169: 1153-1168, 1989.
  • Romani, N., Koide, S., Crowley, M., Witmer-Pack, M., Livingston, A.M., Fathman, C.G., Inaba, K., and Steinman, R.M. Presentation of exogenous protein antigens by dendritic cells to T cell clones: intact protein is presented best by immature, epidermal Langerhans cells. J. Exp. Med. 169: 1169-1178, 1989.
  • Young, J.W., and Steinman, R.M. Dendritic cells stimulate primary human cytolytic lymphocyte responses in the absence of CD4+ helper T cells. J. Exp. Med. 171: 1315-1332, 1990.
  • Metlay, J.P., Witmer-Pack, M.D., Agger, R., Crowley, M.T., Lawless, D., and Steinman, R.M. The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies. J. Exp. Med. 171: 1753-1771, 1990.
  • Crowley, M.T., Inaba, K., and Steinman, R.M. Dendritic cells are the principal cell in mouse spleen bearing immunogenic fragments of foreign proteins. J. Exp. Med. 172: 383-386, 1990.
  • Inaba, K., Metlay, J.P., Crowley, M.T., and Steinman, R.M. Dendritic cells pulsed with protein antigens in vitro can prime antigen specific, MHC restricted T cells in situ. J. Exp. Med. 172: 631-640, 1990.
  • Crowley, M.T., Inaba, K., Witmer-Pack, M., Gezelter, S., and Steinman, R.M. Use of the fluorescence activated cell sorter to enrich dendritic cells from mouse spleen. J. Immunol. Methods. 133: 55-67, 1990.
  • Puré, E., Inaba, K., Crowley, M.T., Tardelli, L., Witmer-Pack, M.D., Ruberti, G., Fathman, G., and Steinman, R.M. Antigen processing by epidermal Langerhans cells correlates with the level of biosynthesis of MHC class II molecules and expression of invariant chain. J. Exp. Med. 172: 1459-1469, 1990.
  • Freudenthal, P.S., and Steinman, R.M. The distinct surface of human blood dendritic cells as observed following an improved isolation method. Proc. Natl. Acad. Sci. USA 87: 7698-7702, 1990.
  • Larsen, C.P., Steinman, R.M., Witmer-Pack, M.D., Hankins, D.F., Morris, P.J., and Austyn, J.M. Migration and maturation of Langerhans cells in skin transplants and explants. J. Exp. Med. 172: 1483-1493, 1990.
  • Inaba, K., Steinman, R.M., Witmer-Pack, M., Aya, H., Inaba, M., Sudo, T., Wolpe, S., and Schuler, G. Identification of proliferating dendritic cell precursors in mouse blood. J. Exp. Med. 175: 1157-1167, 1992.
  • Cameron, P.U., Freudenthal, P.S., Barker, J.M., Gezelter, S., Inaba, K., and Steinman, R.M. Dendritic cells exposed to Human Immunodeficiency Virus-1 transmit a vigorous cytopathic infection to CD4+ T cells. Science 257: 383-387, 1992.
  • Inaba, K., Inaba, M., Romani, N., Aya, H., Deguchi, M., Ikehara, S., Muramatsu, S., and Steinman, R.M. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte-macrophage colony stimulating factor. J. Exp. Med. 176: 1693-1702, 1992.
  • Inaba, K., Inaba, M., Deguchi, M., Hagi, K., Yasumizu, R., Ikehara, S., Muramatsu, S., and Steinman, R.M. Granulocytes, macrophages, and dendritic cells arise from a common major histocompatibility complex class II-negative progenitor in mouse bone marrow. Proc. Natl. Acad. Sci. USA. 90: 3038-3042, 1993.
  • Bhardwaj, N., Young, J.W., Nisanian, A.J., Baggers, J., and Steinman, R.M. Small amounts of superantigen on dendritic cells are sufficient to initiate T cell responses. J. Exp. Med. 178: 633-642, 1993.
  • Inaba, K., Inaba, M., Naito, M., and Steinman, R.M. Dendritic cell progenitors phagocytose particulates, including Bacillus Calmette-Guerin organisms, and sensitize mice to mycobacterial antigens in vivo. J. Exp. Med. 178: 479-488, 1993.
  • Pope, M., Betjes, M.G.H, Romani, N., Hirmand, H., Cameron, P.U., Hoffman, L., Gezelter, S., Schuler, G., and Steinman, R.M. Conjugates of dendritic cells and memory T lymphocytes from skin facilitate productive infection with HIV-1. Cell 78: 389-398, 1994.
  • Inaba, K., Witmer-Pack, M., Inaba, M., Sakuta, H., Hathcock, K.S., Azuma, M., Yagita, H., Okumura, K., Linsley, P.S., Ikehara, S., Muramatsu, S., Hodes, R.J., and Steinman, R.M. The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro. J. Exp. Med. 180: 1849-1860, 1994.
  • Bhardwaj, N., Bender, A., Gonzalez, N., Bui, L.K., Garrett, M.C., and Steinman, R.M. Influenza virus-infected dendritic cells stimulate strong proliferative and cytolytic responses from human CD8+ T cells. J. Clin. Invest. 94: 797-807,1994.
  • Romani, N., Gruner, S., Brang, D., Kampgen, E., Lenz, A., Trockenbacher, B., Konwalinka, G., Fritsch, P.O., Steinman, R.M., and Schuler, G. Proliferating dendritic cell progenitors in human blood. J. Exp. Med. 180:83-93, 1994.