Skip to Main Content

Publications

  1. J Dekker, AS Belmont, M Guttman, VO Leshyk, JT Lis, S Lomvardas, LA Mirny, CC O'Shea, PJ Park, B Ren, JCR Politz, J Shendure, S Zhong; 4D Nucleome Network. The 4D nucleome project. Nature. 2017 Sep 13;549(7671):219-226. doi: 10.1038/nature23884.
  2. R. Hayama, M.P. Rout, J. Fernandez-Martinez. The nuclear pore complex core scaffold and permeability barrier: variations of a common theme. Curr Opin Cell Biol. 2017 Jun;46:110-118. doi: 10.1016/j.ceb.2017.05.003. Epub 2017 Jun 15. Review. 

  3. P.T. Manna, S.O. Obado, C. Boehm, C. Gadelha, A. Sali, B.T. Chait, M.P. Rout, M.C. Field. Lineage-specific proteins essential for endocytosis in trypanosomes. J Cell Sci. 2017 Apr 15;130(8):1379-1392. doi: 10.1242/jcs.191478. Epub 2017 Feb 23.

  4. S.O. Obado, M.C. Field, M.P. Rout. “Comparative interactomics provides evidence for functional specialization of the nuclear pore complex.” Nucleus. 2017 May 2:1-13. doi: 10.1080/19491034.2017.1313936. [Epub ahead of print] PMID: 28463551

  5. M.P. Rout, M.C. Field. The Evolution of Organellar Coat Complexes and Organization of the Eukaryotic Cell. Annu Rev Biochem. 2017 Jun 20;86:637-657. doi: 10.1146/annurev-biochem-061516-044643. Epub 2017 May 3. Review.

  6. M.P. Rout, S.O. Obado, S. Schenkman, M.C. Field. Specialising the parasite nucleus: Pores, lamins, chromatin, and diversity. PLoS Pathog. 2017 Mar 2;13(3):e1006170. doi: 10.1371/journal.ppat.1006170. eCollection 2017 Mar. 

  7. P. Upla, S.J. Kim, P. Sampathkumar, K. Dutta, S.M. Cahill, I.E. Chemmama, R. Williams, J.B. Bonanno, W.J. Rice, D.L. Stokes, D. Cowburn, S.C. Almo, A. Sali, M.P. Rout, J. Fernandez-Martinez. Molecular Architecture of the Major Membrane Ring Component of the Nuclear Pore Complex. Structure. 2017 Feb 2. pii: S0969-2126(17)30006-0. doi: 10.1016/j.str.2017.01.006. [Epub ahead of print]

  1. C.M. Boehm, S. Obado, C. Gadelha, A. Kaupisch, P.T. Manna, G.W. Gould, M. Munson, B.T. Chait, M.P. Rout, M.C. Field. The Trypanosome Exocyst: A Conserved Structure Revealing a New Role in Endocytosis. PLoS Pathog. 2017 Jan 23;13(1):e1006063. doi: 10.1371/journal.ppat.1006063.

  2. LaCava, H. Jiang, M.P. Rout. Protein Complex Affinity Capture from Cryomilled Mammalian Cells. J Vis Exp. 2016 Dec 9;(118). doi: 10.3791/54518. 

  3. B.L. Timney, B. Raveh, R. Mironska, J.M. Trivedi, S.J. Kim, D. Russel, S.R. Wente, A. Sali, M.P. Rout. Simple rules for passive diffusion through the nuclear pore complex. J Cell Biol. 2016 Oct 10;215(1):57-76.

  4. S.O. Obado, M.P. Rout. Cilia and Nuclear Pore Proteins: Pore No More? Dev Cell. 2016 Sep 12;38(5):445-6. doi: 10.1016/j.devcel.2016.08.019.

  5. Maishman, S.O. Obado, S. Alsford, J.M. Bart, W.M. Chen, A.V. Ratushny, M. Navarro, D. Horn, J.D. Aitchison, B.T. Chait, M.P. Rout, M.C. Field. Co-dependence between trypanosome nuclear lamina components in nuclear stability and control of gene expression. Nucleic Acids Res. 2016 Sep 12. pii: gkw751. [Epub ahead of print]

  6. M. Domanski, P. Upla, W.J. Rice, K.R. Molloy, N.E. Ketaren, D.L. Stokes, T.H. Jensen, M.P. Rout, J. LaCava. Purification and analysis of endogenous human RNA exosome complexes. RNA. 2016 Sep;22(9):1467-75. doi: 10.1261/rna.057760.116. Epub 2016 Jul 11.

  7. Y. Luo, E.Y. Jacobs, T.M. Greco, K.D. Mohammed, T. Tong, S. Keegan, J.M. Binley, I.M. Cristea, D. Fenyö, M.P. Rout, B.T. Chait, M.A. Muesing. HIV-host interactome revealed directly from infected cells. Nat Microbiol. 2016 Jul;1(7). pii: 16068. Epub 2016 May 23.

  8. J. LaCava, J. Fernandez-Martinez, Z. Hakhverdyan, M.P. Rout. Protein Complex Purification by Affinity Capture. Cold Spring Harb Protoc. 2016 Jul 1;2016(7):pdb.top077545. doi: 10.1101/pdb.top077545.

  9. J. Fernandez-Martinez, J. LaCava, M.P. Rout. Density Gradient Ultracentrifugation to Isolate Endogenous Protein Complexes after Affinity Capture. Cold Spring Harb Protoc. 2016 Jul 1;2016(7):pdb.prot087957. doi: 10.1101/pdb.prot087957.

  10. J. LaCava, J. Fernandez-Martinez, M.P. Rout. Native Elution of Yeast Protein Complexes Obtained by Affinity Capture. Cold Spring Harb Protoc. 2016 Jul 1;2016(7):pdb.prot087940. doi: 10.1101/pdb.prot087940.

  11. J. LaCava, J. Fernandez-Martinez, Z. Hakhverdyan, M.P. Rout. Optimized Affinity Capture of Yeast Protein Complexes. Cold Spring Harb Protoc. 2016 Jul 1;2016(7):pdb.prot087932. doi: 10.1101/pdb.prot087932.

  12. B. Raveh, J.M. Karp, S. Sparks, K. Dutta, M.P. Rout, A. Sali, D. Cowburn. Slide-and-exchange mechanism for rapid and selective transport through the nuclear pore complex. Proc Natl Acad Sci U S A. 2016 May 3;113(18):E2489-97. doi: 10.1073/pnas.1522663113. Epub 2016 Apr 18.

  13. S.O. Obado, M.C. Field, B.T. Chait, M.P. Rout. High-Efficiency Isolation of Nuclear Envelope Protein Complexes from Trypanosomes. Methods Mol Biol. 2016;1411:67-80. doi: 10.1007/978-1-4939-3530-7_3.

  14. B.T. Chait, M. Cadene, P.D. Olinares, M.P. Rout, Y. Shi. Revealing Higher Order Protein Structure Using Mass Spectrometry. J Am Soc Mass Spectrom. 2016 Apr 14. [Epub ahead of print]

  15. M.S. Taylor, J. LaCava, L. Dai, P. Mita, K.H. Burns, M.P. Rout, J.D. Boeke. Characterization of L1-Ribonucleoprotein Particles. Methods Mol Biol. 2016;1400:311-38. doi: 10.1007/978-1-4939-3372-3_20.

  16. N. Kellner, J. Schwarz, M. Sturm, J. Fernandez-Martinez, S. Griesel, W. Zhang, B.T. Chait, M.P. Rout, U. Kück, E. Hurt. Developing genetic tools to exploit Chaetomium thermophilum for biochemical analyses of eukaryotic macromolecular assemblies. Sci Rep. 2016 Feb 11;6:20937. doi: 10.1038/srep20937.

  17. P.D. Olinares, A.D. Dunn, J.C. Padovan, J. Fernandez-Martinez, M.P. Rout, B.T. Chait. A robust workflow for native mass spectrometric analysis of affinity-isolated endogenous protein assemblies. Anal Chem. 2016 Feb 5. [Epub ahead of print]

  18. M.K.Thompson, P.C. Fridy, S. Keegan, B.T. Chait, D. Fenyö, M.P. Rout. Optimizing selection of large animals for antibody production by screening immune response to standard vaccines. J Immunol Methods. 2016 Jan 9. pii: S0022-1759(16)30005-9. doi: 10.1016/j.jim.2016.01.006. [Epub ahead of print]

  19. M.R. Heider, M. Gu, C.M. Duffy, A.M. Mirza, L.L. Marcotte, A.C. Walls, N. Farrall, Z. Hakhverdyan, M.C. Field, M.P. Rout, A. Frost, M. Munson. Subunit connectivity, assembly determinants and architecture of the yeast exocyst complex. Nat Struct Mol Biol. 2016 Jan;23(1):59-66. doi: 10.1038/nsmb.3146. Epub 2015 Dec 14.

  20. J.D. Aitchison, M.P. Rout. The interactome challenge. J Cell Biol. 2015 Nov 23;211(4):729-32. doi: 10.1083/jcb.201510108. Epub 2015 Nov 16.

  21. L.E. Hough, K. Dutta, S. Sparks, D.B. Temel, A. Kamal, J. Tetenbaum-Novatt, M.P. Rout. D. Cowburn. The molecular mechanism of nuclear transport revealed by atomic-scale measurements. Elife. 2015 Sep 15;4. pii: e10027. doi: 10.7554/eLife.10027.

  22. Shi, R. Pellarin, P.C. Fridy, J. Fernandez-Martinez, M.K. Thompson, Y. Li, Q.J. Wang, A. Sali, M.P. Rout, B.T. Chait. A strategy for dissecting the architectures of native macromolecular assemblies. Nat Methods. 2015 Dec;12(12):1135-8. doi: 10.1038/nmeth.3617. Epub 2015 Oct 5.

  23. Z. Hakhverdyan, M. Domanski, L. Hough, A.A. Oroskar, A.R. Oroskar, S. Keegan, D.J. Dilworth, K. Molloy, V. Sherman, J.D. Aitchison, D. Fenyö, B.T. Chait, T.H. Jensen, M.P. Rout and J. LaCava. Rapid, Optimized Interactomic Screening. Nat Methods. 2015 Jun;12(6):553-60. doi: 10.1038/nmeth.3395 
  24. S. Dokudovskaya, M.P. Rout. SEA you later alli-GATOR - a dynamic regulator of the TORC1 stress response pathway. J Cell Sci. 2015 Jun 15;128(12):2219-2228. Epub 2015 May 1. Review. 
  25. C.L. Lord, B.L. Timney, M.P. Rout, S.R. Wente. Altering nuclear pore complex function impacts longevity and mitochondrial function in S. cerevisiae. J Cell Biol. 2015 Mar 16;208(6):729-44. doi: 10.1083/jcb.201412024. 
  26. J. LaCava, K.R. Molloy, M.S. Taylor, M. Domanski, B.T. Chait, M.P. Rout. Affinity proteomics to study endogenous protein complexes: pointers, pitfalls, preferences and perspectives. Biotechniques. 2015 Mar 1;58(3):103-19. doi: 10.2144/000114262. eCollection 2015 Mar. 
  27. P.C. Fridy, M.K. Thompson, N.E. Ketaren, M.P. Rout. Engineered high-affinity nanobodies recognizing staphylococcal Protein A and suitable for native isolation of protein complexes. Anal Biochem. 2015 May 15;477:92-4. doi: 10.1016/j.ab.2015.02.013. Epub 2015 Feb 21. 
  28. P.C. Fridy, Y. Li, S. Keegan, M.K. Thompson, I. Nudelman, J.F. Scheid, M. Oeffinger, M.C. Nussenzweig, D. Fenyö, B.T. Chait, and M.P. Rout. A robust pipeline for rapid production of versatile nanobody repertoires. Nature Methods. 2014 Dec;11(12):1253-60. doi: 10.1038/nmeth.3170. Epub 2014 Nov 2.

  29. Y. Shi, J. Fernandez-Martinez, E. Tjioe, R. Pellarin, S.J. Kim, R. Williams, D. Schneidman, A. Sali, M.P. Rout, B.T. Chait. Structural characterization by cross-linking reveals the detailed architecture of a coatomer-related heptameric module from the nuclear pore complex.  Mol Cell Proteomics. 2014 Aug 26. [Epub ahead of print] 
  30. S.J. Kim, J. Fernandez-Martinez, P. Sampathkumar, A. Martel, T. Matsui, H. Tsuruta, T. Weiss, A. Markina-Inarrairaegui, J.B. Bonanno, J.M. Sauder, S.K. Burley, S.C. Almo, M. Rout, A. Sali. Integrative structure-function mapping of the nucleoporin Nup133 suggests a conserved mechanism for membrane anchoring of the nuclear pore complex.  Mol Cell Proteomics. 2014 Aug 19. pii: mcp.M114.040915. [Epub ahead of print]
  31. J.M. Holden, L. Koreny, S. Kelly, B.T. Chait, M.P. Rout, M.C. Field, S.O. Obado. Touching from a distance: Evolution of interplay between the nuclear pore complex, nuclear basket, and the mitotic spindle. Nucleus. 2014 Jul 31;5(4). [Epub ahead of print] Review.
  32. R. Algret, J. Fernandez-Martinez, Y. Shi, S.J. Kim, R. Pellarin, P. Cimermancic, E. Cochet, A. Sali, B.T. Chait, M.P. Rout, S. Dokudovskaya. Molecular architecture and function of the SEA complex, a modulator of the TORC1 pathway. Mol Cell Proteomics. 2014 Jul 29. pii: mcp.M114.039388. [Epub ahead of print]
  33. M.P. Rout, G.H. Karpen. Editorial overview: Cell nucleus: the nucleus: a dynamic organelle. Curr Opin Cell Biol. 2014 Jun;28:iv-vii. doi: 10.1016/j.ceb.2014.05.005. Epub 2014 Jun 4. No abstract available.
  34. D.N. Simon, M.P. Rout. Cancer and the nuclear pore complex. Adv Exp Med Biol. 2014;773:285-307. doi: 10.1007/978-1-4899-8032-8_13. 
  35. T. Jovanovic-Talisman, B.T. Chai, M.P. Rout. NPC Mimics: Probing the Mechanism of Nucleocytoplasmic Transport. Methods Cell Biol. 2014;122:379-93. doi: 10.1016/B978-0-12-417160-2.00017-5. 
  36. J.M. Holden, L. Koreny, S. Obado, A.V. Ratushny, W.M. Chen, J.H. Chiang, S. Kelly, B.T. Chait, J.D. Aitchison, M.P. Rout, M.C. Field. Nuclear pore complex evolution: A trypanosome Mlp analog functions in chromosomal segregation but lacks transcriptional barrier activity. Mol Biol Cell. 2014 Mar 5. [Epub ahead of print]
  37. M.C. Field, L. Koreny, M.P. Rout. Enriching the pore: Splendid complexity from humble origins. Traffic. 2014 Feb;15(2):141-56. doi: 10.1111/tra.12141. Epub 2014 Jan 8.
  38. P.R. Andersen, M. Domanski, M.S. Kristiansen, H. Storvall, E. Ntini, C. Verheggen, A. Schein, J. Bunkenborg, I. Poser, M. Hallais, R. Sandberg, A. Hyman, J. Lacava, M.P. Rout, J.S. Andersen, E. Bertrand, T.H. Jensen. The human cap-binding complex is functionally connected to the nuclear RNA exosome. Nat Struct Mol Biol. 2013 Dec;20(12):1367-76. doi: 10.1038/nsmb.2703. Epub 2013 Nov 24.
  39. M.S. Taylor, J. Lacava, P. Mita, K.R. Molloy, C.R. Huang, D. Li, E.M. Adney, H. Jiang, K.H. Burns, B.T. Chait, M.P. Rout, J.D. Boeke, L. Dai. Affinity Proteomics Reveals Human Host Factors Implicated in Discrete Stages of LINE-1 Retrotransposition. Cell. 2013 Nov 21;155(5):1034-48. doi: 10.1016/j.cell.2013.10.021.
  40. M. Niepel, K.R. Molloy, R. Williams, J.C. Farr, A.C. Meinema, N. Vecchietti, I.M. Cristea, B.T. Chait, M.P. Rout, C. Strambio-De-Castillia. The nuclear basket proteins Mlp1p and Mlp2p are part of a dynamic interactome including Esc1p and the proteasome. Mol Biol Cell. 2013 Oct 30. [Epub ahead of print]
  41. T.C. Smith, P.C. Fridy, Y. Li, S. Basil, S. Arjun, R.M. Friesen, J. Leszyk, B.T. Chait, M.P. Rout, E.J. Luna. Supervillin binding to myosin II and synergism with anillin are required for cytokinesis. Mol Biol Cell. 2013 Dec;24(23):3603-19. doi: 10.1091/mbc.E12-10-0714. Epub 2013 Oct 2.
  42. J. Lacava, N. Chandramouli, H. Jiang, M.P. Rout. Improved native isolation of endogenous protein a-tagged protein complexes. Biotechniques. 2013 Apr;54(4):213-6. doi: 10.2144/000114012.
  43. P. Sampathkumar, S.J. Kim, P. Upla, W.J. Rice, J. Phillips, B.L. Timney, U. Pieper, J.B. Bonanno, J. Fernandez-Martinez, Z. Hakhverdyan, N.E. Ketaren, T. Matsui, T.M. Weiss, D.L. Stokes, J.M. Sauder, S.K. Burley, A. Sali, M.P. Rout, S.C. Almo.Structure, Dynamics, Evolution, and Function of a Major Scaffold Component in the Nuclear Pore Complex. Structure. 2013 Mar 12. doi:pii: S0969-2126(13)00045-2. 10.1016/j.str.2013.02.005. [Epub ahead of print]
  44. M.C. Field, D. Horn, S. Alsford, Koreny L, MP. Rout. Telomeres, tethers and trypanosomes. Nucleus. 2012 Sep 19;3(6). [Epub ahead of print] 
  45. P. Sampathkumar, S.J. Kim, D. Manglicmot, K.T. Bain, J. Gilmore, T. Gheyi, J. Phillips, U. Pieper, J. Fernandez-Martinez, J.D. Franke, T. Matsui, H. Tsuruta, S. Atwell, D.A. Thompson, J.S. Emtage, S.R. Wasserman, M.P. Rout, A. Sali, J.M. Sauder, S.C. Almo, S.K. Burley. Atomic structure of the nuclear pore complex targeting domain of a Nup116 homologue from the yeast, Candida glabrataProteins. 2012 Aug;80(8):2110-6. doi: 10.1002/prot.24102. Epub 2012 Jun 
  46. M. Domanski, K. Molloy, H. Jiang, B.T. Chait, M.P. Rout, T.H. Jensen and J. LaCava. Improved Methodology for the Affinity Isolation of Human Protein Complexes Expressed at Near Endogenous LevelsBiotechniques, May 2012, pp. 1–6.
  47. S.O. Obado, M.P. Rout. Ciliary and nuclear transport: different places, similar routes? Dev Cell. 2012 Apr 17;22(4):693-4. 
  48. K.N. DuBois, S. Alsford, J.M. Holden, J. Buisson, M. Swiderski, J.M. Bart, A.V. Ratushny, Y. Wan, P. Bastin, J.D. Barry, M. Navarro, D. Horn, J.D. Aitchison, M.P. Rout, M.C. Field. NUP-1 Is a large coiled-coil nucleoskeletal protein in trypanosomes with lamin-like functionsPLoS Biol. 2012 Mar;10(3):e1001287. Epub 2012 Mar 27
  49. J. Aitchison, M.P. Rout. The yeast nuclear pore complex and transport through it. Genetics. 2012 Mar;190(3):855-83.
  50. J. Tetenbaum-Novatt, L.E. Hough, R. Mironska, A.S. McKenney, M.P. Rout. Nucleocytoplasmic transport: A role for non-specific competition in karyopherin-nucleoporin interactions. Mol Cell Proteomics. 2012 Feb 22. [Epub ahead of print] 

  51. J. Fernandez-Martinez, J. Phillips, M.D. Sekedat, R. Diaz-Avalos, J. Velazquez-Muriel, J.D. Franke, R. Williams, D.L. Stokes, B.T. Chait, A. Sali, M.P .Rout. Structure-function mapping of a heptameric module in the nuclear pore complex.  J Cell Biol 2012 Feb 20;196(4):419-434. 

  52. J. Fernandez-Martinez, M.P. Rout. A jumbo problem: mapping the structure and functions of the nuclear pore complex. Curr Opin Cell Biol. 2012 Feb;24(1):92-9. Epub 2012 Feb 8.

  53. M.C. Field, V. Adung'a, S. Obado, B.T. Chait, M.P. Rout. Proteomics on the rims: insights into the biology of the nuclear envelope and flagellar pocket of trypanosomes. Parasitology. 2012 Feb 6:1-10. [Epub ahead of print] 

  54. S. Dokudovskaya, M.P. Rout. A novel coatomer-related SEA complex dynamically associates with the vacuole in yeast and is implicated in the response to nitrogen starvation. Autophagy. 2011 Nov;7(11):1392-3. Epub 2011 Nov 1. 
  55. D. Grünwald, R.H. Singer, M. Rout. Nuclear export dynamics of RNA-protein complexes. Nature. 2011 Jul 20;475(7356):333-41. doi: 10.1038/nature10318. 

  56. J.M. Keck, M.H. Jones, C.C.L. Wong, J. Binkley, D.C. Chen, S.L. Jaspersen, E.P. Holinger, T. Xu, M. Niepel, M.P. Rout, J. Vogel, A. Sidow, J.R. Yates III, M. Winey.  A Cell Cycle Phosphoproteome of the Yeast Centrosome. Science 2011 Jun 24;332(6037):1557-1561. 

  57. M.C. Field, A. Sali, MP Rout. Evolution: On a bender--BARs, ESCRTs, COPs, and finally getting your coat. J Cell Biol. 2011 Jun 13;193(6):963-72.
  58. S. Dokudovskaya, F. Waharte, A. Schlessinger, U. Pieper, D.P. Devos, I.M. Cristea, R. Williams, J. Salamero, B.T. Chait, A. Sali, M.C. Field, M.P. Rout, C. Dargemont. A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae. Mol Cell Proteomics. 2011 Jun 10(6):M110.006478. Epub 2011 Mar 31.
  59. J. Tetenbaum-Novatt, M.P. Rout. The Mechanism of Nucleocytoplasmic Transport through the Nuclear Pore Complex. Cold Spring Harb Symp Quant Biol. 2010;75:567-84. Epub 2011 Mar 29.
  60. P. Sampathkumar, T. Gheyi, S.A. Miller, K.T. Bain, M. Dickey, J.B. Bonanno, S.J. Kim, J. Phillips, U. Pieper, J. Fernandez-Martinez, J.D. Franke, A. Martel, H. Tsuruta, S. Atwell, D.A. Thompson, J.S. Emtage, S.R. Wasserman, M.P. Rout, A. Sali, J.M. Sauder, S.K. Burley. Structure of the C-terminal domain of Saccharomyces cerevisiae Nup133, a component of the nuclear pore complex. Proteins. 2011 May;79(5):1672-7. doi: 10.1002/prot.22973. Epub 2011 Mar 1.
  61. S.R. Wente, M.P. Rout. The nuclear pore complex and nuclear transport. Cold Spring Harb Perspect Biol. 2010 Oct 1;2(10):a000562. Epub 2010 Jul 14. Review.
  62. C. Strambio-De-Castillia, M. Niepel, M.P. Rout. The nuclear pore complex: bridging nuclear transport and gene regulation. Nat Rev Mol Cell Biol. 2010 Jul;11(7):490-501. Review.
  63. S.S. Terhune, N.J. Moorman, I.M. Cristea, J.P. Savaryn, C. Cuevas-Bennett, M.P. Rout, B.T. Chait, T. Shenk.  "Human cytomegalovirus UL29/28 protein interacts with components of the NuRD complex which promote accumulation of immediate-early RNA." PLoS Pathog. 6 (2010) e1000965.
  64. A. Zilman, S. Di Talia, T. Jovanovic-Talisman, B.T. Chait, M.P. Rout, M.O. Magnasco. "Enhancement of transport selectivity through nano-channels by non-specific competition." PLoS Comput Biol. 6 (2010) e1000804.
  65. P. Sampathkumar, S.A. Ozyurt, J. Do, K.T. Bain, M. Dickey, L.A. Rodgers, T. Gheyi, A. Sali, S.J. Kim, J. Phillips, U. Pieper, J. Fernandez-Martinez, J.D. Franke, A. Martel, H. Tsuruta, S. Atwell, D.A. Thompson, J.S. Emtage, S.R. Wasserman, M.P. Rout, J.M. Sauder, S.K. Burley.  "Structures of the autoproteolytic domain from the Saccharomyces cerevisiae nuclear pore complex component, Nup145." Proteins. 2010 Jun;78(8):1992-8.
  66. I.M. Cristea, N.J. Moorman, S.S. Terhune, C.D. Cuevas, E.S. O'Keefe, M.P. Rout, B.T. Chait, T. Shenk.  "Human Cytomegalovirus pUL83 Stimulates Activity of the Viral Immediate-Early Promoter through its Interaction with the Cellular IFI16 Protein." J. Virology 2010 Aug. 84(15):7803-14. Epub 2010 May 26..
  67. I.M. Cristea, H. Rozjabek, K.R. Molloy, S. Karki, L.L. White, C.M. Rice, M.P. Rout, B.T. Chait, M.R. Macdonald. "Host factors associated with the Sindbis virus RNA-dependent RNA polymerase: a role for G3BP1 and G3BP2 in virus replication." J Virol. 2010 Jul;84(13):6720-32. Epub 2010 Apr 14.
  68. M. Oeffinger, D. Zenklusen, A. Ferguson, K.E. Wei, A. El Hage, D. Tollervey, B.T. Chait, R.H. Singer, M.P. Rout. "Rrp17p is a eukaryotic exonuclease required for 5' end processing of Pre-60S ribosomal RNA." Mol Cell. 2009 Dec 11;36(5):768-81.
  69. J.A. DeGrasse, K.N. DuBois, D. Devos, T.N. Siegel, A. Sali, M.C. Field, M.P. Rout, B.T. Chait. "Evidence for a shared nuclear pore complex architecture that is conserved from the last common eukaryotic ancestor." Mol Cell Proteomics. 2009 Sep;8(9):2119-30. Epub 2009 Jun 13.
  70. J. Fernandez-Martinez, M.P. Rout. "Nuclear pore complex biogenesis." Curr Opin Cell Biol. 2009 Aug;21(4):603-12. Epub 2009 Jun 11. Review.
  71. T. Jovanovic-Talisman, J. Tetenbaum-Novatt, A.S. McKenney, A. Zilman, R. Peters, M.P. Rout, B.T. Chait. "Artificial nanopores that mimic the transport selectivity of the nuclear pore complex." Nature. 2009 Feb 19;457(7232):1023-7. Epub 2008 Dec 21.
  72. D.J. Lew, M.P. Rout. "Cell structure and dynamics." Curr Opin Cell Biol. 2009 Feb;21(1):1-3.
  73. J.A. Degrasse, B.T. Chait, M.C. Field, M.P. Rout. "High-yield isolation and subcellular proteomic characterization of nuclear and subnuclear structures from trypanosomes." Methods Mol Biol. 2008;463:77-92.
  74. M.P. Rout. "The peroxisome: a production in four acts." J Cell Biol. 181(2) (2008) 185-7.
  75. N.J. Moorman, I.M. Cristea, S.S. Terhune, M.P. Rout, B.T. Chait, T. Shenk. "Human cytomegalovirus protein UL38 inhibits host cell stress responses by antagonizing the tuberous sclerosis protein complex." Cell Host Microbe. 3(4) (2008) 253-62.
  76. L.F. Westblade, L. Minakhin, K. Kuznedelov, A.J. Tackett, E.J. Chang, R.A. Mooney, I. Vvedenskaya, Q. Wang, F.W. Studier, M.P. Rout, R. Landick, B.T. Chait, K. Severinov, S.A. Darst. "Rapid isolation and identification of T4 bacteriophage-encoded modifications of Escherichia coli RNA polymerase using immunoisolation and MALDI MS." J. Proteome Res. 7(3) (2008) 1244-50.
  77. F. Alber, S. Dokudovskaya, L.M. Veenhoff, W. Zhang, J. Kipper, D. Devos, A. Suprapto, O. Karni-Schmidt, R. Williams, B.T. Chait, M.P. Rout, A. Sali. "Determining the architectures of macromolecular assemblies." Nature 450 (2007) 683-694.
  78. F. Alber, S. Dokudovskaya, L.M. Veenhoff, W. Zhang, J. Kipper, D. Devos, A. Suprapto, O. Karni-Schmidt, R. Williams, B.T. Chait, A. Sali, M.P. Rout. "The molecular architecture of the nuclear pore complex." Nature 450 (2007) 695-701.
  79. M. Oeffinger, K.E. Wei, R. Rogers, J.A. Degrasse, B.T. Chait, J.D. Aitchison, M.P. Rout. "Comprehensive analysis of diverse ribonucleoprotein complexes." Nat Methods. (11) (2007) 951-6.
  80. J. Zhang, P. Harnpicharnchai, J. Jakovljevic, L. Tang, Y. Guo, M. Oeffinger, M.P. Rout, S.L. Hiley, T. Hughes, J.L. Woolford, Jr. "Assembly factors Rpf2 and Rrs1 recruit 5S rRNA and ribosomal proteins rpL5 and rpL11 into nascent ribosomes." Genes Dev. 21(20) (2007) 2580-92.
  81. A. Zilman, S. Di Talia, B.T. Chait, M.P. Rout, M.O. Magnasco. "Efficiency, Selectivity, and Robustness of Nucleocytoplasmic Transport." PLoS Comput Biol. 3(7) (2007) e125.
  82. M. Oeffinger, A. Fatica, M.P. Rout, D. Tollervey. "Yeast Rrp14p is required for ribosomal subunit synthesis and for correct positioning of the mitotic spindle during mitosis." Nucleic Acids Res. 35(4) (2007) 1354-66.
  83. B.L. Timney, J. Tetenbaum-Novatt, D.S. Agate, R. Williams, W. Zhang, B.T. Chait, M.P. Rout. "Simple kinetic relationships and nonspecific competition govern nuclear import rates in vivo." J Cell Biol. 175(4) (2006) 579-93.
  84. D.M. Leslie, B. Timney, M.P. Rout, J.D. Aitchison. "Studying nuclear protein import in yeast." Methods 39(4) (2006) 291-308.
  85. Q.J. Wang, Y. Ding, S. Kohtz, N. Mizushima, I.M. Cristea, M.P. Rout, B.T. Chait, Y. Zhong, N. Heintz, Z. Yue. "Induction of autophagy in axonal dystrophy and degeneration." J Neurosci. 26(31) (2006) 8057-68.
  86. I.M. Cristea, J.W. Carroll, M.P. Rout, C.M. Rice, B.T. Chait, M.R. Macdonald. "Tracking and elucidating alphavirus-host protein interactions." J Biol Chem.281(40) (2006) 30269-78.
  87. S. Dokudovskaya, R. Williams, D. Devos, A. Sali, B.T. Chait, M.P. Rout. "Protease Accessibility Laddering: a proteomic tool for probing protein structure." Structure 14(4) (2006) 653-60.
  88. D. Devos, S. Dokudovskaya, R. Williams, F. Alber, N. Eswar, B.T. Chait, M.P. Rout, A. Sali. "Simple fold composition and modular architecture of the nuclear pore complex." Proc. Natl. Acad. Sci. USA 103(7) (2006) 2172-7.
  89. C. Strambio-de-Castillia, J. Tetenbaum-Novatt, B.S. Imai, B.T. Chait, M.P. Rout. "A Method for the Rapid and Efficient Elution of Native Affinity-Purified Protein A Tagged Complexes." J Proteome Res. 4(6) (2005) 2250-6.
  90. I.M. Cristea, R. Williams, B.T. Chait, M.P. Rout. "Fluorescent proteins as proteomic probes." Mol Cell Proteomics. 4(12) (2005) 1933-194.
  91. A.J. Tackett, J.A. DeGrasse, M.D. Sekedat, M. Oeffinger, M.P. Rout, B.T. Chait. "I-DIRT, a general method for distinguishing between specific and nonspecific protein interactions." J Proteome Res. 4(5) (2005) 1752-6.
  92. A.J. Tackett, D.J. Dilworth, M.J. Davey, M. O'Donnell, J.D. Aitchison, M.P. Rout, B.T. Chait. "Proteomic and genomic characterization of chromatin complexes at a boundary." J Cell Biol. 169(1) (2005) 35-47.
  93. M. Niepel, C. Strambio-de-Castillia, J. Fasolo, B.T. Chait, M.P. Rout. "The nuclear pore Complex-associated protein, Mlp2p, binds to the yeast spindle pole body and promotes its efficient assembly." J Cell Biol. 170(2) (2005) 225-35.
  94. D. Devos, S. Dokudovskaya, F. Alber, R. Williams, B.T. Chait, A. Sali, M.P. Rout. "Components of Coated Vesicles and Nuclear Pore Complexes Share a Common Molecular Architecture." PLoS Biology 2 (12) (2004) e380.
  95. D.M. Leslie, W. Zhang, B.L. Timney, B.T. Chait, M.P. Rout, R.W. Wozniak, J.D. Aitchison. "Characterization of karyopherin cargoes reveals unique mechanisms of kap121p-mediated nuclear import." Mol Cell Biol. 24 (19) (2004) 8487-503.
  96. V. Archambault, E.J. Chang, B.J. Drapkin, F.R. Cross, B.T. Chait, M.P. Rout. "Targeted proteomic study of the Cyclin-Cdk module." Mol. Cell 14(6) (2004) 699-711.
  97. B.L. Timney and M.P. Rout. "Robbing from the pore." Nat. Cell Biol. 6 (2004) 177-9.
  98. M.P. Rout, J.D. Aitchison, M.O. Magnasco and B.T. Chait. "Virtual gating and nuclear transport: the hole picture." Trends Cell Biol. 13 (2003) 622-8.
  99. V. Archambault, C.X. Li, A.J. Tackett, R. Wäsch, B.T. Chait, M.P. Rout, F.R. Cross. "Genetic and biochemical evaluation of the importance of Cdc6 in regulating mitotic exit." Mol. Biol. Cell 14 (2003) 4592-604.
  100. D.M. Leslie, B. Grill, M.P. Rout, R.W. Wozniak, J.D. Aitchison. "Kap121p-mediated nuclear import is required for mating and cellular differentiation in yeast." Mol. Cell. Biol. 8 (2002) 2544-55.
  101. J.D. Aitchison and M.P. Rout. "A tense time for the nuclear envelope." Cell 108 (2002) 301-304.
  102. S. Dokudovskaya, L.M. Veenhoff, M.P. Rout. "Cleave to leave: structural insights into the dynamic organization of the nuclear pore complex." Mol Cell. 10(2): (2002) 221-3.
  103. J. Kipper, C. Strambio-de-Castillia, A. Suprapto, M.P. Rout. "Isolation of nuclear envelope from Saccharomyces cerevisiae." Methods Enzymol. 351 (2002) 394-408.
  104. C. Strambio-de-Castillia, M.P. Rout. "The structure and composition of the yeast NPC." Results Probl Cell Differ. 35 (2002) 1-23.
  105. M.P. Rout and M.C. Field. "Isolation and characterisation of subnuclear compartments from Trypanosoma brucei: identification of a major repetitive nuclear lamina component." J. Biol. Chem. 276 (2001) 38261-38271.
  106. P. Harnipicharnchai, J. Jakovljevic, E. Horsey, T. Miles, J. Roman, M. Rout, D. Meagher, B. Imai, Y. Guo, C. J. Brame, J. Shabanowitz, D. F. Hunt, J. L. Woolford, Jr. "Composition and Functional Characterization of Yeast 66S Ribosome Assembly Intermediates." Mol. Cell 8 (2001) 505-515.
  107. J.D. Aitchison and M.P. Rout. "The Nuclear Envelope and Nucleocytoplasmic Transport." In: The Encyclopedia of Genetics, Harcourt Press. (2001).
  108. D. J. Dilworth, A. Suprapto, J. C. Padovan, B.T. Chait, R.W. Wozniak, M.P. Rout and J.D. Aitchison. "Nup2p Dynamically Associates with the Distal Regions of the Yeast Nuclear Pore Complex." J. Cell Biol. 153 (2001) 1465-1478.
  109. J.D. Aitchison, M.P. Rout. "The nuclear pore complex as a transport machine." J Biol Chem. 276(20) (2001) 16593-6.
  110. J.D. Aitchison and M.P. Rout "The Road to Ribosomes: Filling Potholes in the Export Pathway." J. Cell Biol. 151 (2000) 23-26.
  111. M.P. Rout, J.D. Aitchison, A. Suprapto, K. Hjertaas, Y. Zhao and B.T. Chait. "The yeast nuclear pore complex: composition, architecture and mechanism." J. Cell. Biol. 148 (2000) 635-652.
  112. M.P. Rout, and J.D. Aitchison. "Pore Relations: Nuclear Pore Complexes and Nucleocytoplasmic Exchange." Essays in Biochemistry 36 (2000) 79-85.
  113. C. Strambio-de-Castillia, G. Blobel and M.P. Rout. "Proteins Connecting the Nuclear Pore Complex with the Nuclear Interior." J. Cell Biol. 144 (1999) 839-850.
  114. C. Strambio-de-Castillia and M.P. Rout. "TAPping into transport." Nat Cell Biol. 1:E3 (1999) 1-3.
  115. Q. Yang, M.P. Rout and C.W. Akey. "Three-Dimensional Architecture of the Isolated Yeast Nuclear Pore Complex: Functional and Evolutionary Implications." Mol. Cell, 1 (1998) 223-234.
  116. M.P. Rout and J.V. Kilmartin. "Preparation of Yeast Spindle Pole Bodies" Cell Biology : A Laboratory Handbook, vol. 2, 120-128 (1998), 2nd Edition.
  117. M.P. Rout and C. Strambio-de-Castillia. "Isolation of Yeast Nuclear Pore Complexes and Nuclear Envelopes" Cell Biology : A Laboratory Handbook, vol. 2, 143-152 (1998), 2nd Edition.
  118. R.W. Wozniak, M.P. Rout and J.D. Aitchison. "Karyopherins and Kissing Cousins." Trends Cell Biol. 8 (1998) 184-188.
  119. H. Chial, M.P. Rout, T. H. Giddings, Jr. , and M. Winey. "Saccharomyces cerevisiae Ndc1p is a Shared Component of Nuclear Pore Complexes and Spindle Pole Bodies" J. Cell Biol. 143 (1998) 1789-1800.
  120. M.P. Rout, G. Blobel and J.D. Aitchison. "A Distinct Nuclear Import Pathway Used by Ribosomal Proteins." Cell, 89 (1997) 715-725.
  121. E. Bullitt, M.P. Rout, J.V. Kilmartin and C.W. Akey. "The Yeast Spindle Pole Body Is Assembled around a Central Crystal of Spc42p." Cell, 89 (1997) 1077-1086.
  122. U. Nehrbass, M.P. Rout, S. Maguire, G. Blobel and R.W. Wozniak. "Nup188p, a Novel Yeast Nucleoporin, Is Part of a Functionally Interacting Group of Major Nuclear Pore Complex Constituents." J. Cell Biol. 133 (1996) 1153-1162.
  123. J.D. Aitchison, G. Blobel and M.P. Rout. "KAP104: A Novel Yeast Karyopherin that Imports hnRNP Proteins into the Nucleus." Science, 274 (1996) 624-627.
  124. L.F. Pemberton, M.P. Rout and G. Blobel. "Disruption of the Nucleoporin Gene NUP133 Results in Clustering of Nuclear Pore Complexes." Proc. Natl. Acad. Sci. USA 92 (1995) 1187-1191.
  125. D.M. Kraemer, C. Strambio-de-Castillia, G. Blobel and M.P. Rout. "The Essential Yeast Nucleoporin NUP159 Is Located on the Cytoplasmic Side of the Nuclear Pore Complex and Serves in Karyopherin-mediated Binding of Transport Substrate." J. Biol. Chem. 270 (1995) 19017-19021.
  126. C. Strambio-de-Castillia, G. Blobel and M.P. Rout. "Isolation and Characterization of the Yeast Nuclear Envelope." J. Cell Biol. 131 (1995) 19-31.
  127. J.D. Aitchison, M.P. Rout, M. Marelli, G. Blobel and R.W. Wozniak. "Two Novel Related Yeast Nucleoporins Nup170p and Nup157p: Complementation with the Vertebrate Homologue Nup155p and Functional Interactions with the Yeast Nuclear Pore-Membrane Protein Pom152p." J. Cell Biol. 131 (1995) 1133-1148.
  128. J.D. Aitchison, G. Blobel and M.P. Rout. "Nup120p: A Yeast Nucleoporin Required for NPC Distribution and mRNA Transport." J. Cell Biol. 131 (1995) 1659-1675.
  129. R.W. Wozniak, G. Blobel and M.P. Rout. "POM152 is an Integral Protein of the Pore Membrane Domain of the Yeast Nuclear Envelope." J. Cell Biol. 125 (1994) 31-42.
  130. M.P. Rout and S.R. Wente. "Pores for Thought: Nuclear Pore Complex Proteins." Trends Cell Biol. 4 (1994) 357-365.
  131. M.P. Rout and J.V. Kilmartin. "Preparation of Yeast Spindle Pole Bodies." Cell Biology: A Laboratory Handbook, vol. 1, (1994) 605-612
  132. M.P. Rout and G. Blobel. "Isolation of the Yeast Nuclear Pore Complex." J. Cell Biol. 123 (1993) 771-783.
  133. S.R. Wente, M.P. Rout and G. Blobel. "A New Family of Yeast Nuclear Pore Complex Proteins." J. Cell Biol. 119 (1992) 705-723.
  134. M.P. Rout and J.V. Kilmartin. "Yeast Spindle Pole Body Components." CSH Symp. Quant. Biol. LVI (1991) 687-692.
  135. M.P. Rout and J.V. Kilmartin. "Components of the Yeast Spindle and Spindle Pole Body." J. Cell Biol. 111 (1990) 1913-1927.
J Dekker, AS Belmont, M Guttman, VO Leshyk, JT Lis, S Lomvardas, LA Mirny, CC O'Shea, PJ Park, B Ren, JCR Politz, J Shendure, S Zhong; 4D Nucleome Network. The 4D nucleome project. Nature. 201