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Live Imaging of Neuronal Migration along Glial Fibers

By differential interference contrast, Nomarski optics, immature granule neurons form an interstitial adhesion junction beneath the cell soma and extend a specialized, migratory process along the underlying glial fiber. In this sequence, a neuron moves along a glial fiber at approximately 50 microns/h. Migration occurs in a series of steps, with forward movement initiated by the release of the adhesion beneath the cell soma. From Edmondson JC, Hatten ME. 1987. Glial-guided granule neuron migration in vitro: a timelapse video microscopic study. J Neurosci 7:1928-34
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