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Thursday, February 9, 2012

LABORATORY OF MAMMALIAN CELL BIOLOGY AND DEVELOPMENT

• Overview
• Introduction
• The Basics About Research in the Fuchs Laboratory
• Past and Current Research
  • Epidermal Differentiation, the Cytoskeleton and Blistering Skin Diseases
  • Cell Adhesion, the Cytoskeleton and Cancers
  • Stem Cells of the Skin and Their Lineages
• Lectures
• News
• Lab Members
  • Current Lab Members
  • Fuchs Biographical Sketch
  • Past Record of Training
• Lab Photos
• Multimedia
• Job Postings
• Database Material
• Publications
• Links
• Materials Requests
• Contact Us
• 

Selected Publications

(104 of 272 publications )

• Hsu YC, Fuchs E.  “A family business: stem cell progeny join the niche to regulate homeostasis.” Nat Rev Mol Cell Biol 13(2):103-14 (2012).

• Oshimori N, Fuchs E.  “Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation.” Cell Stem Cell 10(1):63-75 (2012).

• Beronja S, Fuchs E.  A breath of fresh air in lung regeneration.  Cell 147(3):485-7 (2011).

• Lien WH, Guo X, Polak L, Lawton LN, Young RA, Zheng D, Fuchs E. "Genome-wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage." Cell Stem Cell 9(3):219-32 (2011) .

• Devenport D, Oristian D, Heller E, Fuchs E. "Mitotic internalization of planar cell polarity proteins preserves tissue polarity." Nat Cell Biol 13(8):893-902 (2011).
• Ezratty EJ, Stokes N, Chai S, Shah AS, Williams SE, Fuchs E. "A role for the primary cilium in Notch signaling and epidermal differentiation during skin development." Cell 145(7):1129-41 (2011).
• Schober M, Fuchs E. "Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF-? and integrin/focal adhesion kinase (FAK) signaling." Proc Natl Acad Sci U S A 108(26):10544-9 (2011).
• Fuchs E. "Reflections of an ISSCR president, 2010-2011." Cell Stem Cell 8(6):629-30 (2011).
• Fuchs E, Horsley V. "Ferreting out stem cells from their niches." Nat Cell Biol 13(5):513-8 (2011).
• Kaneko H, Dridi S, Tarallo V, Gelfand BD, Fowler BJ, Cho WG, Kleinman ME, Ponicsan SL, Hauswirth WW, Chiodo VA, Karikó K, Yoo JW, Lee DK, Hadziahmetovic M, Song Y, Misra S, Chaudhuri G, Buaas FW, Braun RE, Hinton DR, Zhang Q, Grossniklaus HE, Provis JM, Madigan MC, Milam AH, Justice NL, Albuquerque RJ, Blandford AD, Bogdanovich S, Hirano Y, Witta J, Fuchs E, Littman DR, Ambati BK, Rudin CM, Chong MM, Provost P, Kugel JF, Goodrich JA, Dunaief JL, Baffi JZ, Ambati J. "DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration." Nature 471 (7338):325-30 (2011).
• Zhang L, Stokes N, Polak L, Fuchs E. "Specific MicroRNAs Are Preferentially Expressed by Skin Stem Cells To Balance Self-Renewal and Early Lineage Commitment." Cell Stem Cell 8(3):294-308 (2011).
• Luxenburg C, Amalia Pasolli H, Williams SE, Fuchs E. "Developmental roles for Srf, cortical cytoskeleton and cell shape in epidermal spindle orientation." Nat Cell Biol 13(3):203-14 (2011).
• Williams SE, Beronja S, Pasolli HA, Fuchs E. "Asymmetric cell divisions promote Notch-dependent epidermal differentiation." Nature 470(7334):353-8 (2011).
• Ezhkova E, Lien WH, Stokes N, Pasolli HA, Silva JM, Fuchs E. "EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair." Genes Dev 25(5):485-98 (2011).
• Wu X, Shen QT, Oristian DS, Lu CP, Zheng Q, Wang HW, Fuchs E. "Skin Stem Cells Orchestrate Directional Migration by Regulating Microtubule-ACF7 Connections through GSK3β." Cell 144(3):341-52 (2011).
• Zhang H, Pasolli HA, Fuchs E. "Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin." Proc Natl Acad Sci U S A 108(6):2270-5 (2011).
• Zaidi MR, Davis S, Noonan FP, Graff-Cherry C, Hawley TS, Walker RL, Feigenbaum L, Fuchs E, Lyakh L, Young HA, Hornyak TJ, Arnheiter H, Trinchieri G, Meltzer PS, De Fabo EC, Merlino G. "Interferon-? links ultraviolet radiation to melanomagenesis in mice." Nature 469(7331):548-53 (2011).
• Hsu YC, Pasolli HA, Fuchs E. "Dynamics between stem cells, niche, and progeny in the hair follicle." Cell 144(1):92-105 (2011).
• Seidel K, Ahn CP, Lyons D, Nee A, Ting K, Brownell I, Cao T, Carano RA, Curran T, Schober M, Fuchs E, Joyner A, Martin GR, de Sauvage FJ, Klein OD. "Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor. Development 137(22):3753-61 (2010).
• Fuchs E. "Toward a knowledge of causes." Cell Stem Cell 7(3):315-7 (2010).
• Ezhkova E, Fuchs E."Regenerative medicine: An eye to treating blindness." Nature 466(7306):567-8 (2010).
• Beronja S, Livshits G, Williams S, Fuchs E. "Rapid functional dissection of genetic networks via tissue-specific transduction and RNAi in mouse embryos." Nat Med 16(7):821-7 (2010).
• Nguyen H, Merrill BJ, Polak L, Nikolova M, Rendl M, Shaver TM, Pasolli HA, Fuchs E. "Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia." Nat Genet 41(10):1068-1075 (2009).
• Coulombe PA, Kerns ML, Fuchs E. "Epidermolysis bullosa simplex: a paradigm for disorders of tissue fragility." J Clin Invest 119(7):1784-93 (2009).
• Fuchs E. "Building confidence:the transition from student to professor." Nat Cell Biol 11(7):786 (2009).
• Silva JM, Ezhkova E, Silva J, Heart S, Castillo M, Campos Y, Castro V, Bonilla F, Cordon-Cardo C, Muthuswamy SK, Powers S, Fuchs E, Hannon GJ. "Cyfip1 is a putative invasion suppressor in epithelial cancers." Cell 137(6):1047-61 (2009).
• Fuchs E. "Finding one's niche in the skin." Cell Stem Cell 4(6):499-502 (2009).
• Fuchs E. "The tortoise and the hair: slow-cycling cells in the stem cell race." Cell 137(5):811-9 (2009).
• Ezhkova E, Pasolli HA, Parker JS, Stokes N, Su IH, Hannon G, Tarakhovsky A, Fuchs E. "Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells." Cell 136(6):1122-35 (2009).
• Blanpain C, Fuchs E. "Epidermal homeostasis: a balancing act of stem cells in the skin." Nat Rev Mol Cell Biol 10(3):207-17 (2009).
• Greco V, Chen T, Rendl M, Schober M, Pasolli HA, Stokes N, Dela Cruz-Racelis J, Fuchs E. "A two-step mechanism for stem cell activation during hair regeneration." Cell Stem Cell 4(2):155-69 (2009).
• Yi R, Pasolli HA, Landthaler M, Hafner M, Ojo T, Sheridan R, Sander C, O'Carroll D, Stoffel M, Tuschl T, Fuchs E. "DGCR8-dependent microRNA biogenesis is essential for skin development." Proc Natl Acad Sci U S A 106(2):498-502 (2009).
• Nowak JA, Fuchs E. "Isolation and culture of epithelial stem cells." Methods Mol Biol 482:215-32 (2009)
• Fuchs E, Nowak JA. "Building Epithelial Tissues from Skin Stem Cells." Cold Spring Harb Symp Quant Biol (2008).
• Wu X, Kodama A, Fuchs E. "ACF7 regulates cytoskeletal-focal adhesion dynamics and migration and has ATPase activity." Cell 135(1):137-48 (2008).
• Devenport D, Fuchs E. "Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair follicles." Nat Cell Biol 10(11):1257-68 (2008).
• Wang X, Pasolli HA, Williams T, Fuchs E. "AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis." J Cell Biol 183(1):37-48 (2008).
• Tinkle CL, Pasolli HA, Stokes N, Fuchs E. "New insights into cadherin function in epidermal sheet formation and maintenance of tissue integrity." Proc Natl Acad Sci USA 105(40):15405-10 (2008).
• Perez-Moreno M, Song W, Pasolli HA, Williams SE, Fuchs E. "Loss of p120 catenin and links to mitotic alterations, inflammation, and skin cancer." Proc Natl Acad Sci USA 105(40):15399-404 (2008).
• Nowak JA, Polak L, Pasolli HA, Fuchs E. "Hair follicle stem cells are specified and function in early skin morphogenesis." Cell Stem Cell. 3(1):33-43 (2008).
• Fuchs E, Horsley V. "More than one way to skin . . ." Genes Dev 22(8): 976-85 (2008).
• Yi R, Poy MN, Stoffel M, Fuchs E. "A skin microRNA promotes differentiation by repressing ’stemness’." Nature 452(7184): 225-9 (2008).
• Rendl M, Polak L, Fuchs E. "BMP signaling in dermal papilla cells is required for their hair follicle-inductive properties." Genes Dev 22(4): 543-57 (2008).
• Fuchs E. "Skin stem cells: rising to the surface." J Cell Biol 180(2): 273-84 (2008).
• Horsley V, Aliprantis AO, Polak L, Glimcher LH, and Fuchs E. "NFATc1 Balances Quiescence and Proliferation of Skin Stem Cells." Cell 132: 299-310, (2008).
• Guasch G, Schober M, Pasolli HA, Conn EB, Polak L, Fuchs E. "Loss of TGFbeta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia." Cancer Cell. 12(4):313-27 (2007).
• Kobielak K, Stokes N, de la Cruz J, Polak L, Fuchs E. "Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling." Proc Natl Acad Sci U S A 104(24):10063-10068 (2007).
• Schober M, Raghavan S, Nikolova M, Polak L, Pasolli HA, Beggs HE, Reichardt LF, Fuchs E. "Focal adhesion kinase modulates tension signaling to control actin and focal adhesion dynamics." J Cell Biol 176: 667-680 (2007).
• Fuchs E. "Scratching the surface of skin development." Nature 445: 834-842 (2007).
• Li J, Greco V, Guasch G, Fuchs E, Mombaerts P. "Mice cloned from skin cells." Proc Natl Acad Sci U S A 104: 2738-2743 (2007).
• Blanpain C, Horsley V, Fuchs E. "Epithelial Stem Cells: Turning over New Leaves." Cell 128: 445-58 (2007).
• Lechler T, Fuchs E. "Desmoplakin: an unexpected regulator of microtubule organization in the epidermis." J Cell Biol 176: 147-54 (2007).
• Blanpain C, Lowry WE, Pasolli HA, Fuchs E. "Canonical notch signaling functions as a commitment switch in the epidermal lineage." Genes Dev 20: 3022-35 (2006).
• Perez-Moreno M and Fuchs E. "Catenins: Keeping cells from getting their signals crossed." Dev Cell 11: 601-612 (2006).
• Blanpain C and Fuchs E. "Epidermal Stem Cells of the Skin." Annu Rev Cell Dev Biol 22: 339-73 (2006).
• Nguyen H, Rendl M, Fuchs E. "Tcf3 governs stem cell features and represses cell fate determination in the skin." Cell 127: 171-183 (2006).
• Horsley V, O'Carroll D, Tooze R, Ohinata Y, Saitou M, Obukhanych T, Nussenzweig M, Tarakhovsky A, and Fuchs E. "Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland." Cell 126(3):597-609 (2006).
• Blanpain C and Fuchs E. "Epidermal Stem Cells of the Skin." Annu Rev Cell Dev Biol 22: 339-73 (2006).
• Rhee H, Polak L, and Fuchs E. "Lhx2 maintains stem cell character in hair follicles." Science 312:1946-9 (2006).
• Kobielak A and Fuchs E. "Links between alpha-catenin, NF-kappaB, and squamous cell carcinoma in skin." Proc Natl Acad Sci U S A 103: 2322-7 (2006).
• Perez-Moreno M., Davis MA, Wong E, Pasolli HA, Reynolds AB, and Fuchs E. "p120-catenin mediates inflammatory responses in the skin." Cell 124: 631-44 (2006).
• Yi R, O'Carroll D, Pasolli HA, Zhang Z, Dietrich FS, Tarakhovsky A, and Fuchs E. "Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs." Nat Genet 38: 356-62 (2006).
• Wang X, Bolotin D, Chu DH, Polak L, Williams T, and Fuchs E. "AP-2alpha: a regulator of EGF receptor signaling and proliferation in skin epidermis." J Cell Biol 172(3): 409-21 (2006).
• Guasch G and Fuchs E. "Mice in the world of stem cell biology." Nat Genet 37: 1201-6 (2005).
• Rendl M, Lewis L, and Fuchs E. "Molecular dissection of mesenchymal-epithelial interactions in the hair follicle." PLoS Biol 3: 1910-23 (2005).
• Lechler T and Fuchs E. "Asymmetric cell divisions promote stratification and differentiation of mammalian skin." Nature 437: 275-280 (2005).
• Alonso L, Okada H, Pasolli HA, Wakeham A, You-Ten AI, Mak TW, Fuchs E. "Sgk3 links growth factor signaling to maintenance of progenitor cells in the hair follicle." J Cell Biol 170: 559-70 (2005).
• Lowry WE, Blanpain C, Nowak JA, Guasch G, Lewis L, Fuchs E. "Defining the impact of beta-catenin/Tcf transactivation on epithelial stem cells." Genes Dev 19: 1596-1611 (2005).
• Jamora C, Lee P, Kocieniewski P, Azhar M, Hosokawa R, Chai Y, Fuchs E. "A signaling pathway involving TGF-beta2 and snail in hair follicle morphogenesis." PLoS Biol 3: 131-143 (2005).
• Blanpain C, Lowry WE, Geoghegan A, Polak L. and Fuchs E. "Self renewal, multipotency and the existence of two cell populations within an epithelial stem cell niche." Cell 118: 635-648 (2004).
• Fuchs E, Tumbar T, and Guasch G. "Socializing with the neighbors: stem cells and their niches." Cell 116: 769-778 (2004).
• TumbarT, Guasch G, Greco V, Blanpain C, Lowry WE, Rendl M and Fuchs E. "Defining the epithelial stem cell niche of the skin." Science 303: 359-363 (2004).
• Kobielak A, Pasolli HA, and Fuchs E. "Mammalian formin1 participates in adherens junctions and polymerization of linear actin cables." Nat Cell Biol 6: 21-30 (2004).
• Tinkle CL, Lechler T, Pasolli HA, and Fuchs E. "Conditional targeting of E-cadherin in skin: Insights into hyperproliferative and degenerative responses." Proc Natl Acad Sci U S A 101: 552-557 (2004).
• Merrill BJ, Pasolli HA, Polak L, Rendl M, Garcia-Garcia MJ, Anderson K, and Fuchs E. "Tcf3: A transcriptional regulator of axis induction in the early embryo." Development 131: 263-274 (2004).
• Kobielak K, Pasolli HA, Alonso L, Polak L, and Fuchs E. "Defining BMP functions in the hair follicle by conditional ablation of BMP Receptor IA." J Cell Biol 163: 609-624 (2003).
• Kodama A, Karakesisoglou I, Wong E, Polak L, and Fuchs E. "ACF7: An essential integrator of microtubule dynamics." Cell 115: 343-354 (2003).
• Kaufman CK, Pasolli HA, Rendl M, Bolotin D, Lim KC,Dai X, Alegre ML, and Fuchs E."GATA-3: An unexpected regulator of cell lineage determination in skin." Genes Dev 17: 2108-2122 (2003).
• Raghavan S, Vaezi A, and Fuchs E. "A Role for alphabeta1 integrins in focal adhesion regulation and polarized cytoskeletal dynamics." Dev Cell 5: 415-427 (2003).
• Jamora C, DasGupta R, Kocieniewski P, and Fuchs E. "Links between signal transduction, transcription and adhesion in epithelial bud development." Nature 422: 317-322 (2003).
• Bolotin D and Fuchs E. "Cancer: More than skin deep." Nature 421:594-595 (2003).
• Perez-Moreno M, Jamora C, and Fuchs E. "Sticky business: orchestrating cellular signals at adherens junctions." Cell 112: 535-48 (2003).
• Vaezi A, Bauer C, Vasioukhin V, and Fuchs E. "Actin cable dynamics and Rho/Rock orchestrate a polarized cytoskeletal architecture in assembling a stratified epithelium." Dev Cell 3: 367-381 (2002).
• Jamora C and Fuchs E. "Intercellular adhesion and signaling." Nat Cell Biol 4: 101-108 (2002).
• Merrill BJ, Gat U, DasGupta R and Fuchs E. "Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin." Genes Dev 15: 1688-1705 (2001).
• Vasioukhin V, Bauer C, Degenstein L, Wise B, and Fuchs E. "Hyperproliferation and defects in epithelial polarity upon conditional ablation of alpha-catenin in skin." Cell 104: 605-617 (2001).
• Vasioukhin V, Bowers E, Bauer C, Degenstein L, and Fuchs E. "Desmoplakin plays an essential role in epidermal sheet formation." Nat Cell Biol 3: 1076-1085 (2001).
• Raghavan S, Bauer C, Mundschau G, Li Q, and Fuchs E. "Conditional ablation of beta1 integrin in skin. Severe defects in epidermal proliferation, basement membrane formation, and hair follicle invagination." J Cell Biol 150: 1149-60 (2000).
• Vasioukhin V, Bauer C, Yin M, and Fuchs E. "Directed actin polymerization is the driving force for epithelial cell-cell adhesion." Cell 100: 209-219 (2000).
• Chan EF, Gat U, McNiff JM, and Fuchs, E. "A common human skin tumour is caused by activating mutations in beta-catenin." Nat Genet 21: 410-3 (1999).
• DasGupta R and Fuchs E. "Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation." Development 126: 4557-68 (1999).
• Yang Y, Bauer C, Strasser G, Wollman R, Julien JP and Fuchs E. "Integrators of the cytoskeleton that stabilize microtubules." Cell 98: 229-38 (1999).
• Gat U, DasGupta R, Degenstein L, and Fuchs E. "De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in Skin." Cell 95: 605-614 (1998).
• Fuchs E and Cleveland D. "Structural scaffolding of IFs in health and disease." Science 279: 514-519 (1998).
• Yang Y, Dowling J, Yu QC, Kouklis P, Cleveland DW and Fuchs E. "An essential cytoskeletal linker protein connecting actin microfilaments to intermediate filaments." Cell 86: 655-65 (1996).
• Guo L, Degenstein L, Dowling J, Yu QC, Wollmann R, Perman B and Fuchs E. "Gene targeting of BPAG1: abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration." Cell 81: 233-43 (1995).
• Paller AS, Syder AJ, Chan YM, Yu QC, Hutton E, Tadini G, and Fuchs E. "Genetic and clinical mosaicism in a type of epidermal nevus." N Engl J Med 331: 1408-15 (1994).
• Cheng J, Syder AJ, Yu Q-C, Letai A, Paller AS, and Fuchs E. "The genetic basis of EH, a disorder of differentiation-specific epidermal keratin genes." Cell 70:811-819 (1992).
• Coulombe PA, Hutton ME, Letai A, Hebert A, Paller AS and Fuchs E. "Point mutations in human keratin 14 genes of epidermolysis bullosa simplex patients: genetic and functional analyses." Cell 66:1301-11 (1991).
• Vassar R, Coulombe PA, Degenstein L, Albers K and Fuch E. "Mutant keratin expression in transgenic mice causes marked abnormalities resembling a human genetic skin disease." Cell 64: 365-80 (1991).
• Hanukoglu I and Fuchs E. "The cDNA sequence of type II cytoskeletal keratin reveals constant and variable structural domains among keratins." Cell 33:915-924 (1983).
• Hanukoglu I. and Fuchs E. "The cDNA sequence of a human epidermal keratin: Divergence of sequence but conservation of structure among intermediate filament proteins." Cell 31:243-52 (1982).
• Fuchs EV, Coppock SM, Green H and Cleveland DW. "Two distinct classes of keratin genes and their evolutionary significance." Cell 27:75-84 (1981).
• Fuchs E and Green H. "Regulation of differentiation of keratinocytes by vitamin A." Cell 25:617-625 (1981).
• Fuchs E and Green H. "Changes in keratin gene expression during terminal differentiation." Cell 19:1033-1042 (1980).
• Fuchs E and Green H. "Multiple keratins of cultured human epidermal cells are translated from different mRNA molecules." Cell 17:573-582 (1979).
• Fuchs E and Green H. "Expression of keratin genes in epidermis and cultured epidermal cells." Cell 15:887-897 (1978).

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