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Past Member Publications

Postdoctoral Fellows and Associates

Agnel Sfeir's Publications:
M. Zimmermann, F. Lottersberger, S. Buonomo, A. Sfeir, T. de Lange (2013) 53BP1 regulates DSB repair using Rif1 to control 5’ end resection. Science 6120: 700-704.

A. Sfeir and T. de Lange (2012) Removal of shelterin reveals the telomere end-protection problem. Science 336: 593-597.

H. Scherthan, A. Sfeir, and T. de Lange (2011) Rap1-independent telomere attachment and bouquet formation in mammalian meiosis. Chromosoma 120: 151-157.

S. Kabir, A. Sfeir, and T. de Lange (2010) Taking apart Rap1: an adaptor protein with telomeric and non-telomeric functions. Cell Cycle 20: 4061-4067.

A. Sfeir, S. Kabir, M. van Overbeek, G.B. Celli, T. de Lange (2010) Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal. Science 327: 1657-1661.

Y Zhao, AJ Sfeir, Y Zou, CM Buseman, TT Chow, JW Shay, WE Wright (2009) Telomere extension occurs at most chromosome ends and is uncoupled from fill-in in human cancer cells. Cell 138: 432-434.

AJ Sfeir, STI Kosiyatraku, D Hockemeyer, SL MacRae, J Karlseder, CL Schildkraut, T de lange (2009) Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. Cell 138: 90-103.

D Hockemeyer, AJ Sfeir, JW Shay, WE Wright, T de lange (2005) POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end. EMBO J  24: 2667-2678.

 

Eros Lazzerini Denchi's Publications:
T. Davoli, E. Lazzerini Denchi, T. de Lange (2010) Persistent Telomere Damage Induces Bypass of Mitosis and Tetraploidy. Cell 141: 81-93.

E. Lazzerini Denchi and T. de Lange (2007) Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1. Nature 448: 1068-71.

E. Lazzerini Denchi, G.B. Celli, and T. de Lange (2006) Hepatocytes with extensive telomere deprotection and fusion remain viable and regenerate liver mass through endoreduplication. Genes and Development 20: 2648-2653.

G.B. Celli, E. Lazzerini Denchi, and T. de Lange (2006) Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination. Nature Cell Biol 8: 855-862.

 

 

Sean Rooney's Publications:
P. Wu, M. van Overbeek, S. Rooney, T. de Lange T. (2010) Apollo Contributes to G Overhang Maintenance and Protects Leading-End Telomeres. Mol. Cell. 39: 1-12..

 

Akimitsu Konishi's Publications:
A. Konishi and T. de Lange (2008) Cell cycle control of telomere protection and NHEJ revealed by a ts mutation in the DNA binding domain of TRF2. Genes and Development 22(9):1221-30.

 

Sara Buonomo's Publications:
M. Zimmermann, F. Lottersberger, S. Buonomo, A. Sfeir, T. de Lange (2013) 53BP1 regulates DSB repair using Rif1 to control 5’ end resection. Science 6120: 700-704.

S. Buonomo, Y. Wu, D. Ferguson, T. de Lange (2009) Mammalian Rif1 contributes to replication stress survival and homology-directed repair. J. Cell Biol. 187:385-398.

J. Silverman, H. Takai, S.B.C. Buonomo, F. Eisenhaber, and T. de Lange (2004) Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. Genes and Development 18: 2108-2119.

 

 

Diego Loayza's Publications:
K. Takai, T. Kibe, J. Donigian, D. Frescas and T. de Lange (2011) Telomere Protection by TPP1/POT1 Requires Tethering to TIN2. Mol. Cell, 44: 647-659.

D. Loayza*, H. Parsons*, J. Donigian, K. Hoke, and T. de Lange (2004) DNA binding features of human POT1: A nonamer 5’-TAGGGTTAG-3’ minimal binding site, sequence specificity, and internal binding to multimeric sites. J. Biol. Chem  279: 13241-13248.

D. Loayza and T. de Lange (2004) Telomerase regulation at the telomere: a binary switch. Cell 117: 279-280.

J. Z.-S. Ye, D. Hockemeyer, A. Krutchinsky, D. Loayza, S. Hooper, B. Chait, and T. de Lange (2004) POT1 Interacting Protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. Genes and Development 18: 1649-1654.

J.Z.-S. Ye*, J. Donigian*, M. van Overbeek*, D. Loayza, B. Chait, A. Krutchinsky, and T. de Lange (2004) TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. J Biol Chem, 279: 47264-47271.

D. Loayza and T. de Lange (2003) POT1 as a terminal transducer of TRF1 telomere length control. Nature 423: 1013-1018.

 

 

Giulia Celli's Publications:
G.B. Celli, E. Lazzerini Denchi, and T. de Lange (2006) Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination. Nature Cell Biol 8: 855-862.

E. Lazzerini Denchi, G.B. Celli, and Titia de Lange (2006) Hepatocytes with extensive telomere deprotection and fusion remain viable and regenerate liver mass through endoreduplication. Genes and Development 20: 2648-2653.

G. Celli and T. de Lange (2005) DNA processing not required for ATM activation or the telomere damage response after conditional deletion of mouse TRF2. Nature Cell Biol 7: 712-718.

 

 

Jeff Ye's Publications:
D. Hockemeyer, W. Palm, T. Else, J.-P. Daniels, K. Takai, J. Z.-S. Ye, T. de Lange, and G. Hammer (2007) Telomere protection by mammalian POT1 requires interaction with TPP1. NatureStructural and Molecular Biology 8:754-61.

J. Z.-S. Ye and T. de Lange (2004) TIN2 is a tankyrase 1 PARP-modulator in the TRF1 telomere length control complex. Nat. Genet. 36: 618-623.

J. Z.-S. Ye, D. Hockemeyer, A. Krutchinsky, D. Loayza, S. Hooper, B. Chait, and T. de Lange (2004) POT1 Interacting Protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. Genes and Development 18: 1649-1654.

J.Z.-S. Ye, J. Donigian*, M. van Overbeek*, D. Loayza, B. Chait, A. Krutchinsky, and T. de Lange (2004) TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. J Biol Chem, 279: 47264-47271.

 

 

Jacqueline Jacob's Publications:
J.J.L. Jacobs and T. de Lange (2005) p16INK4as a second effector of the telomere damage response. Cell Cycle 4: 1364-1368.

J.J.L. Jacobs and T. de Lange (2004) Significant role for p16INK4a in p53-independent telomere-directed senescence. Curr Biol 14: 1-20.

 

 

Xu-Dong Zhu's Publications:
X.-D. Zhu, L. Niedernhofer, B. Kuster, M. Mann, J. H. J. Hoeijmakers, and T. de Lange (2003) ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA containing double minute chromosomes.  MolCell, 6: 1489-1498.

X.-D. Zhu, B. Küster, M. Mann, J.H.J. Petrini, and T. de Lange (2000) Cell cycle regulated association of the Rad50/Mre11/Nbs1 complex with TRF2 and human telomeres.  NatureGenetics 25: 347-352.

L. Zhu, S. Smith, T. de Lange, M. F. Seldin. (1999) Chromosomal mapping of the Tankyrase gene in human and mouse. Genomics 57:320-321.

 

 

Jan Karlseder's Publications:
A. Sfeir, S.T. Kosiyatrakul, D. Hockemeyer, S.L. MacRae, J. Karlseder, C.L. Schildkraut, T. de Lange (2009) Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. Cell.138:90-103.

J. Karlseder, K. Hoke, O. Mirzoeva, C. Bakkenist, M. Kastan, J.H.J. Petrini, and T. de Lange (2004) The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. PLoS Biology 2: 1150-1157.

J. Karlseder, L. Kachatrian, H. Takai, K. Mercer, S. Hingorani, T. Jacks and T. de Lange (2003) Targeted deletion reveals an essential function for the telomere length regulator Trf1. Mol. Cell. Biol., 23: 6533-6541.

J. Karlseder, A. Smogorzewska, and T. de Lange (2002) Senescence induced by altered telomere state, not telomere loss. Science 295:  2446-2449.

A. Smogorzewska, J. Karlseder, A. Jauch, and T. de Lange (2002) DNA ligase IV dependent NHEJ of deprotected human telomeres in G1 and G2. Curr. Biol 12: 1634-1644.

J. Karlseder, D. Broccoli, Y. Dai, S. Hardy, T. de Lange (1999) ATM- and p53-dependent apoptosis induced by telomeres lacking TRF2. Science 283: 1321-1325.

 

 

Bibo Li's Publications:
B. Li and T. de Lange (2003) Rap1 affects the length and heterogeneity of human telomeres. Mol Biol Cell 14: 5060-5068.

S. Hanaoka, A. Nagadoi, S. Yoshimura, S. Aimoto, B. Li, T. de Lange, Y. Nishimura (2001) NMR structure of the hRap1 Myb motif reveals a canonical three helix bundle lacking the positive surface charge typical of Myb DNA binding domains. J. Mol. Biol 312:  167-175.

B. Li, S. Oestreich, and T. de Lange (2000) Identification of Human Rap1: Implications for Telomere Evolution. Cell 101: 471-483.

H. Scherthan, M. Jerratsch, B. Li, S. Smith, M. Hulten, T. Lock, and T. de Lange (2000). Mammalian meiotic telomeres: protein composition and their redistribution in relation to nuclear pores. Mol Bio Cell 11: 4189-4203.

 

 

Susan Smith's Publications:
S. Smith and T. de Lange (2000) Tankyrase promotes telomere elongation. Current Biol10: 1299-1302.

H. Scherthan, M. Jerratsch, B. Li, S. Smith, M. Hulten, T. Lock, and T. de Lange (2000) Mammalian meiotic telomeres: protein composition and their redistribution in relation to nuclear pores. Mol Biol Cell 11: 4189-4203.

L. Zhu, S. Smith, T. de Lange, M. F. Seldin. (1999) Chromosomal mapping of the Tankyrase gene in human and mouse. Genomics 57:320-321.

S. Smith, T. de Lange (1999) Cell cycle dependent localization of tankyrase, a telomeric PARP, to centrosomes and nuclear pore complexes. J. Cell Sci. 112: 3649-3656.

S. Smith, I. Giriat, A. Schmitt, T. de Lange (1998) Tankyrase, a poly(ADP-ribose)polymerase at human telomeres.  Science 282: 1484-1488.

S. Smith and T. de Lange (1997) TRF1, a mammalian telomeric protein. TIG 13: 21-26.

A. Bianchi, S. Smith, L. Chong, P. Elias, T. de Lange (1997) TRF1 is a dimer and bends telomeric DNA. EMBO J 7: 1785-1794.

 

 

Dominique Broccoli's Publications:
J. Karlseder, D. Broccoli, Y. Dai, S. Hardy, T. de Lange (1999) ATM- and p53-dependent apoptosis induced by telomeres lacking TRF2. Science 283: 1321-1325.

D. Broccoli, L. Chong, S. Oelmann, A.A. Fernald, N. Marziliano, B. van Steensel, D. Kipling, M.M. Le Beau, T. de Lange (1997) Comparison of the human and mouse genes encoding the telomeric protein, TRF1: chromosomal localization, expression, and conserved protein domains. HumanMol. Genet 6: 69-76.

D. Broccoli, A. Smogorzewska, L. Chong, T. de Lange (1997) Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nature Genetics 17: 231-235.

D. Broccoli, L.A. Godley, L.A. Donehower, H.E. Varmus, T. de Lange (1996)  Telomerase activation in mouse mammary tumors: lack of telomere shortening and evidence for regulation of telomerase RNA with cell proliferation. Mol Cell Biol 16: 3765-3772.

D. Broccoli, J.W. Young, T. de Lange (1995) Telomerase activity in normal and malignant hematopoietic cells. Proc Nat Acad Sci USA 92: 9082-9086.

L. Chong, B. van Steensel, D. Broccoli, H. Erdjument-Bromage, J. Hanish, P. Tempst, T. de Lange (1995) A human telomeric protein. Science 270: 1663-1667.

 

 

Bas van Steensel's Publications:
L. Chong, B. van Steensel, D. Broccoli, H. Erdjument-Bromage, J. Hanish, P. Tempst, T. de Lange (1995) A human telomeric protein. Science 270: 1663-1667.

M.E.E. Ludérus, B. van Steensel, L. Chong, O.C.M. Sibon, F.F.M. Cremers, T. de Lange (1996) Structure, subnuclear distribution, and nuclear matrix association of the mammalian telomeric complex. J Cell Biol 135: 867-883.

D. Broccoli, L. Chong, S. Oelmann, A.A. Fernald, N. Marziliano, B. van Steensel, D. Kipling, M.M. Le Beau, T. de Lange (1997) Comparison of the human and mouse genes encoding the telomeric protein, TRF1: chromosomal localization, expression, and conserved protein domains. Human Mol Genet 6: 69-76.

B. van Steensel and T. de Lange (1997) Control of telomere length by the human telomeric protein TRF1. Nature 385: 740-744.

B. van Steensel, A. Smogorzewska, T. de Lange (1998) TRF2 protects human telomeres from end-to-end fusions. Cell 92: 401-413.

A. Smogorzewska, B. van Steensel, A. Bianchi, G. Schnapp, M. R. Schaefer, S. Oelmann, T. de Lange (2000) Control of human telomere length by TRF1 and TRF2. Mol Cell Biol 20: 1659-1668.

 

 

Eva Luderus' Publications:
M.E.E. Ludérus, B. van Steensel, L. Chong, O.C.M. Sibon, F.F.M. Cremers, T. de Lange (1996) Structure, subnuclear distribution, and nuclear matrix association of the mammalian telomeric complex. J Cell Biol 135: 867-883.

 

John Hanish's Publications:
L. Chong, B. van Steensel, D. Broccoli, H. Erdjument-Bromage, J. Hanish, P. Tempst, T. de Lange (1995) A human telomeric protein. Science 270: 1663-1667.

J.P. Hanish, J. Yanowitz, T. de Lange (1994) Stringent sequence requirements for telomere formation in human cells. Proc Natl Acad Sci USA 91: 8861-8865.

 

 

Maria Cardenas' Publications:
M.E. Cardenas, A. Bianchi, T. de Lange (1993) A Xenopus egg factor with DNA-binding properties characteristic of terminus-specific telomeric proteins. Genes & Dev 7: 883-894.

 

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Graduate Students



Teresa Davoli Publications:
T. Davoli and T. de Lange (2012) Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation in mouse cells. Cancer Cell 21: 765-776

T. Davoli & T. de Lange (2011) The Causes and Consequences of Polypolidy in Normal Development and Cancer. Annu. Rev. Cell Dev. Biol, 27: 585-610

T. Davoli, E. Lazzerini Denchi, T. de Lange (2010) Persistent Telomere Damage Induces Bypass of Mitosis and Tetraploidy. Cell 141: 81-93.

Peng Wu's Publications:
P. Wu, H. Taka and T. de Lange (2012) Telomeric 3' Overhangs Derive from Resection by Exo1 and Apollo and Fill-In by POT1b-Associated CST. Cell 150: 39-52.

Wu P, van Overbeek M, Rooney S, de Lange T. (2010) Apollo Contributes to G Overhang Maintenance and Protects Leading-End Telomeres. Mol. Cell. ePub ahead of print, July 7, 2010.

P Wu and T de lange (2008) No Overt Nucleosome Eviction at Deprotected Telomeres. Mol Cell Biol 28: 5724-5735

 

 

Megan van Overbeek's Publications:
Chen Y, Yang Y, van Overbeek M, Donigian JR, Baciu P, de Lange T, and Lei M (2008) A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins. Science 319: 1092-6.

van Overbeek M and de Lange T (2006) Apollo, an Artemis related nuclease, interacts with TRF2 and protects human telomeres in S phase. Curr. Biol 16: 1295-1302.

Ye JZ-S, Donigian J, van Overbeek M, Loayza D, Chait B, Krutchinsky A, and de Lange T (2004) TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. J Biol Chem 279: 47264-47271.

 

 

Nadya Dimitrova's Publications:
N. Dimitrova & T. de Lange (2009) Cell cycle dependent role of MRN at dysfunctional telomeres: ATM signaling-dependent induction of NHEJ in G1 and resection-mediated inhibition of NHEJ in G2. Mol. Cell. Biol. 290:5552-5563.

N. Dimitrova, Telomere binding proteins in human cells. Cancer Drug Discovery & Development: Telomeres and Telomerase in Cancer. Humana Press Inc. (2009).

N. Dimitrova, YC. Chen, DL. Spector, T. de Lange (2008) 53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility. Nature 456(7221):524-8.

N. Dimitrova and T. de Lange (2006) MDC1 accelerates nonhomologous end-joining of dysfunctional telomeres. Genes and Development 20: 3238-3243.

 

 

Jill Donigian's Publications:
Y. Chen, Y. Yang, M. van Overbeek, and J. Donigian (2008) A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins. Science 319: 1092-6.

D. Loayza*, H. Parsons*, J. Donigian, K. Hoke, and T. de Lange (2004) DNA binding features of human POT1: A nonamer 5'-TAGGGTTAG-3' minimal binding site, sequence specificity, and internal binding to multimeric sites. J Biol Chem 279: 13241-13248.

J.Z.-S. Ye*, J. Donigian*, M. van Overbeek*, D. Loayza, B. Chait, A. Krutchinsky, and T. de Lange (2004) TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. J Biol Chem 279: 47264-47271.

J. R. Donigian and T. de Lange (2007) The role of tankyrase1 in telomere length control by TRF1. J Biol Chem 282: 22662-7.

 

 

Dirk Hockemeyer's Publications:
A. Sfeir, S.T. Kosiyatrakul, D. Hockemeyer, S.L. MacRae, J. Karlseder, C.L. Schildkraut, T. de Lange (2009) Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. Cell.138:90-103.

W. Palm, D. Hockemeyer, T. Kibe, T. de Lange (2008) Functional dissection of human and mouse POT1 proteins. Mol Cell Biol.29:471-82.

D. Hockemeyer, W. Palm, R. Wang, S. Couto, and T. de Lange (2008) Engineered telomere degradation models dyskeratosis congenita. Genes and Development online DOI:10.1101/gad.1679208

D. Hockemeyer, W. Palm, T. Else, J.-P. Daniels, K. Takai, J. Z.-S. Ye, T. de Lange, and G. Hammer (2007) Telomere protection by mammalian POT1 requires interaction with TPP1. NatureStructural and Molecular Biology, 8:754-61.

D. Hockemeyer, J.-P. Daniels, H. Takai, and T. de Lange (2006) Recent expansion of the telomeric complex in rodents: two distinct POT1 proteins protect mouse telomeres. Cell 126: 63-77.

D. Hockemeyer, A. J. Sfeir, J.W. Shay, W.E. Wright, and T. de Lange (2005) POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end. EMBO J. 24: 2667-2678.

J. Z.-S. Ye, D. Hockemeyer, A. Krutchinsky, D. Loayza, S. Hooper, B. Chait, and T. de Lange
(2004) POT1 Interacting Protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. Genes and Development 18: 1649-1654.

 

 

Kristina Hoke's Publications:
D. Loayza*, H. Parsons*, J. Donigian, K. Hoke, and T. de Lange (2004) DNA binding features of human POT1: A nonamer 5'-TAGGGTTAG-3' minimal binding site, sequence specificity, and internal binding to multimeric sites. J Biol Chem 279: 13241-13248.

J. Karlseder, K. Hoke, O. Mirzoeva, C. Bakkenist, M. Kastan, J.H.J. Petrini, and T. de Lange (2004) The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. PLoS Biology 2: 1150-1157.

 

 

Dirk Hockemeyer's Publications:
D. Hockemeyer, W. Palm, R. Wang, S. Couto, and T. de Lange (2008) Engineered telomere degradation models dyskeratosis congenita. Genes Dev. 22:1773-1785.

H. Takai, R. Wang, K. Takai, H. Yang, and T. de Lange (2007) Tel2 regulates the stability of PI3K-related protein kinases. Cell 131: 1248-1259.

R. Wang, A. Smogorzewska, and T. de Lange (2004) Homologous recombination generates t-loop sized deletions at human telomeres. Cell 119: 355-368.

X. Dong, M.A. Michelis, J. Wang, R. Bose, T. de Lange, W.H. Reeves (1998) Autoantibodies to DEK oncoprotein in a patient with systemic lupus erythematosus and sarcoidosis. Arthritis Rheum. 41:1505-1510.

 

 

Richard Wang's Publications
D. Hockemeyer, W. Palm, R. Wang, S. Couto, and T. de Lange (2008) Engineered telomere degradation models dyskeratosis congenita. Genes Dev. 22:1773-1785.

H. Takai, R. Wang, K. Takai, H. Yang, and T. de Lange (2007) Tel2 regulates the stability of PI3K-related protein kinases. Cell 131: 1248-1259.

R. Wang, A. Smogorzewska, and T. de Lange (2004) Homologous recombination generates t-loop sized deletions at human telomeres. Cell 119: 355-368.

X. Dong, M.A. Michelis, J. Wang, R. Bose, T. de Lange, W.H. Reeves (1998) Autoantibodies to DEK oncoprotein in a patient with systemic lupus erythematosus and sarcoidosis. Arthritis Rheum. 41:1505-1510.

 

 

Joshua Silverman's Publications:
J. Silverman, H. Takai, S.B.C. Buonomo, F. Eisenhaber, and T. de Lange (2004) Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. Genes and Development 18: 2108-2119.

 

 

Agata Smogorzewska's Publications:
A. Smogorzewska and T. de Lange (2004) Regulation of telomerase by telomeric proteins. Ann Rev Biochem 73: 177-208.

R. Wang, A. Smogorzewska, and T. de Lange (2004) Homologous recombination generates t-loop sized deletions at human telomeres. Cell 119: 355-368.

H. Takai, A. Smogorzewska, and T. de Lange (2003) DNA damage foci at dysfunctional telomeres. Curr Biol 13: 1549-1556.

J. Karlseder, A. Smogorzewska, and T. de Lange (2002) Senescence induced by altered telomere state, not telomere loss. Science 295: 2446-2449.

A. Smogorzewska and T. de Lange (2002) Different telomere damage signaling pathways in human and mouse cells. EMBO J 21: 4338-4348.

A. Smogorzewska, J. Karlseder, A. Jauch, and T. de Lange (2002) DNA ligase IV dependent NHEJ of deprotected human telomeres in G1 and G2. Curr Biol 12: 1634-1644.

A. Smogorzewska, B. van Steensel, A. Bianchi, G. Schnapp, M. R. Schaefer, S. Oelmann, T. de Lange (2000) Control of human telomere length by TRF1 and TRF2.  Mol. Cell Biol. 20: 1659-1668.

B. van Steensel, A. Smogorzewska, T. de Lange (1998) TRF2 protects human telomeres from end-to-end fusions. Cell 92: 401-413.

D. Broccoli, A. Smogorzewska, L. Chong, T. de Lange (1997) Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nature Genetics 17: 231-235.

 

 

Alessandro Bianchi's Publications:
A. Smogorzewska, B. van Steensel, A. Bianchi, G. Schnapp, M. R. Schaefer, S. Oelmann, T. de Lange (2000) Control of human telomere length by TRF1 and TRF2. Mol Cell Biol 20: 1659-1668.

J. D. Griffith, L. Comeau, S. Rosenfield, R. Stansel, A. Bianchi, H. Moss, T. de Lange. (1999) Mammalian telomeres end in a large duplex loop. Cell 97: 503-514.

A. Bianchi and T. de Lange (1999) Ku binds telomeric DNA in vitro. J Biol Chem 274: 21223-21227.

A. Bianchi, R. M. Stansel, L. Fairall, J. D. Griffith, D. Rhodes, T. de Lange (1999) TRF1 binds a bipartite telomeric site with extreme spatial flexibility. EMBO J 18: 5735-5744.

J. Griffith, A. Bianchi, T. de Lange (1998) TRF1 promotes parallel pairing of telomeric DNA in vitro. J Mol Biol 278: 79-88.

A. Bianchi, S. Smith, L. Chong, P. Elias, T. de Lange (1997) TRF1 is a dimer and bends telomeric DNA. EMBO J 7: 1785-1794.

M.E. Cardenas, A. Bianchi, T. de Lange (1993) A Xenopus egg factor with DNA-binding properties characteristic of terminus-specific telomeric proteins. Genes & Dev 7: 883-894.

 

 

Henrik Tommerup's Publications:
H. Tommerup, A. Dousmanis, T. de Lange (1994) Unusual chromatin in human telomeres. Mol Cell Biol 14: 5777-5785.


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