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Current Member Publications

Postdoctoral Fellows and Associates


Nazario Bosco Publications:
N. Bosco and T. de Lange (2012) A TRF1-controlled common fragile site containing interstitial telomeric sequences. Chromosoma 121: 465

Pelliccia F*, Bosco N*, Rocchi A (2010) Breakages at common fragile sites set boundaries of amplified regions in two leukemia cell lines K562 � Molecular characterization of FRA2H and localization of a new CFS FRA2S. Cancer Lett, 299(1): 37-44. (*co-first authors)

Bosco N, Pelliccia F, Rocchi A (2010) Characterization of FRA7B, a human common fragile site mapped at the 7p chromosome terminal region. Cancer Genet Cytogenet, 202(1): 47-52.

Pelliccia F, Bosco N, Curatolo A, Rocchi A (2008) Replication timing of two human common fragile sites: FRA1H and FRA2G. Cytogenet Genome Res, 121(3-4):196-200.

Pelliccia F, Curatolo A, Limongi MZ, Bosco N, Rocchi A (2007) Transcriptional profiling of genes at the human common fragile site FRA1H in tumor-derived cell lines. Cancer Genetics and Cytogenetics,178: 144-150.

Ylli Doksani Publications:
Y. Doksani, J.W. Yu, T. de Lange, X. Zhuang (2013) Super-Resolution Fluorescence Imaging of Telomeres Reveals TRF2-Dependent T-Loop Formation. Cell 155: 345-356.

R Bermejo, T Capra, R Jossen, A Colosio, C Frattini, W Carotenuto, A Cocito, Y Doksani, H Klein, B Gomez-Gonzalez, A Aguilera, Y Katou, K Shirahige, and M Foiani, (2011) The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores. Cell 146: 233-246

Y Doksani, R Bermejo, S Fiorani, JE Haber, M Foiani (2009) Replicon dynamics, dormant origin firing, and terminal fork integrity after double-strand break formation. Cell 137: 247-258.

R Bermejo, Y Doksani, T Capra, YM Katou, H Tanaka, K Shirahige, M Foiani (2007) Top1- and Top2-mediated topological transitions at replication forks ensure fork progression and stability and prevent DNA damage checkpoint activation. Genes Dev 21:1921-1936.

C Cotta-Ramusino, D Fachinetti, C Lucca, Y Doksani, M Lopes, J Sogo, M Foiani (2005) Exo1 processes stalled replication forks and counteracts fork reversal in checkpoint-defective cells. Mol Cell 17:15315-15319.


David Frescas Publications:
D. Frescas, and T. de Lange (2014). TRF2-Tethered TIN2 Can Mediate Telomere Protection by TPP1/POT1. Mol Cell Biol 34: 1349-1362.

D. Frescas and T. de Lange (2014)A TIN2 dyskeratosis congenita mutation causes telomerase-independent telomere shortening in mice. Genes and Development 28: 153-166.

K. Takai, T. Kibe, J. Donigian, D. Frescas and T. de Lange (2011) Telomere Protection by TPP1/POT1 Requires Tethering to TIN2. Mol. Cell, 44: 647-659.

D Frescas, D Guardavaccaro, SM Kuchay , H Kato, A Poleshko, V Basrur, KS Elenitoba-Johnson, RA Katz, M Pagano (2008) KDM2A represses transcription of centromeric satellite repeats and maintains the heterochromatic state. Cell Cycle 7: 1-9.

F Bassermann, D Frescas, D Guardavaccaro, L Busino, A Peschiaroli, M Pagano (2008) The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA damage response checkpoint. Cell, 134:256-267.

D Frescas, M Pagano (2008) Deregulated proteolysis by the F-box proteins Skp2 and �-TRCP. Nature Reviews Cancer 8: 438-449.

D Guardavaccaro, D Frescas, NV Dorrello, A Peschiaroli, A Multani, T Cardozo, A Lasorella, A Lavarone, S Chang, E Hernando, M Pagano (2008) Control of chromosome stability by the �-TRCP-REST-MAD2 axis. Nature 452: 365-369.

D Frescas, D Guardavaccaro, F Bassermann, R Koyama-Nasu, M Pagano (2007) JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes. Nature 450: 309-313.

D Frescas, M Mavrakis, H Lorenz, R DeLotto, J Lippincott-Schwartz (2006) The secretory membrane system in the Drosophila syncytial blastoderm embryo exists as functionally compartmentalized units around individual nuclei. J Cell Biol 173: 219-230.

D Frescas, L Valenti L, D Accili (2005) Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes. J Biol Chem 280: 20589-20595.

EL Snapp, T Lida, D Frescas, J Lippincott-Schwartz, MA Lilly (2004) The Fusome Mediates Intercellular ER Connectivity in Drosophila Ovarian Cysts. Mol Cell Biol 15: 4512-4521.


Yi Gong Publications:

Y. Gong and T. de Lange (2010) A Shld1-controlled POT1a provides support for repression of ATR signaling at telomeres through RPA exclusion. Mol. Cell 40: 377-387.

Y Gong, JN Lee, PC Lee, Jl Goldstein, MS Brown, J Ye (2006) Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake. Cell Metabolism 3:15-24.

Y Gong, JN Lee, MS Brown, Jl Goldstein, J Ye (2006) Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis. Proc Nat Acad Sci 103: 6154-6159.

JN Lee, Y Gong, X Zhang, J Ye (2006) Proteasomal degradation of ubiquitinated Insig proteins is determined by serine residues flanking ubiquitinated lysines. Proc Nat Acad Sci 103: 4958-4963.

T Yang, PJ Espenshade, ME Wright, D Yabe, Y Gong, R Aebersold, Jl Goldstein, MS Brown (2002) Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER. Cell 110: 489-500.

G Zhou, H Li, Y Gong, Y Zhao, J Cheng, P Lee, Y Zhao (2005) Proteomic analysis of global alteration of protein expression in squamous cell carcinoma of the esophagus. Proteomics 5: 3814-3821.

G Zhou, H Li, D DeCamp, S Chen, H Shu, Y Gong, M Flaig, JW Gillespie, N Hu, PR Taylor, LA Liotta, MR Emmert-Buck, EF Petricoin III, Y Zhao (2002) 2D differential in-gel electrophoresis for the identification of esophageal squamous cell cancer-specific protein markers. Mol Cell Proteomics 1: 117-124.

DW Yu, T Yang, T Sonoda, Y Gong, Q Cao, K Gaffney, PJ Jensen, IM Freedberg, RM Lavker, TT Sun (2001) Osteopontin gene is expressed in the dermal papilla of pelage follicles in a hair-cycle-dependent manner. J Invest Dermatology 117: 1554-1558.

Y Gong, KD Liu, G Zhou, Q Xie, SL Chen, ZY Tang (1998) Tumor radioimmunoimaging of chimeric antibody in nude mice with hepatoma xenograft. World J Gastroenterology 4: 7-9.


Tatsuya Kibe Publications:
K. Takai, T. Kibe, J. Donigian, D. Frescas and T. de Lange (2011) Telomere Protection by TPP1/POT1 Requires Tethering to TIN2. Mol. Cell, 44: 647-659.

T. Kibe, G.A. Osawa, C.E. Keegan, T. de Lange (2010) Telomere protection by TPP1 is mediated by POT1a and POT1b. Mol. Cell. Biol. 30: 1059-1066.

W. Palm, D. Hockemeyer, T. Kibe, T. de Lange (2008) Functional dissection of human and mouse POT1 proteins. Mol Cell Biol.29:471-82.

T Kibe, Y Ono, K Sato, M Ueno (2007) Fission yeast Taz1 and RPA are synergistically required to prevent rapid telomere loss. Mol Biol Cell 18: 2378-2387

K Tomita, T Kibe, HY Kang, YS Seo, M Uritani, T Ushimaru, M Ueno (2004) Fission yeast Dna2 is required for generation of the telomeric single-strand overhang. Mol Cell Biol 24: 9557-9567


Katja Kratz Publications:
C. Dittrich, K. Kratz, A. Sendoel, Y. Gruenbaum, J. Jiricny, and M.O. Hengartner. (2012). LEM-3 - a novel endonuclease involved in the DNA damage response. PLoS One 7(2):e24555

K. Kratz, B. Schopf, S. Kaden, A. Sendoel, R. Eberhard, C. Lademann, E. Cannavo, AA Sartori, MO Hengartner, J. Jiricny. (2010). Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents. Cell 142, 77-88.

K. Yoshikiyo, K. Kratz, K. Hirota, I. Nishihara, M. Takata, H. Kurumizaka, S. Horimoto, S. Takeda, J. Jiricny. (2010). KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents. PNAS 107, 21553-21557.


Francisca Alessandra Lottersberger Publications:
M. Zimmermann, F. Lottersberger, S. Buonomo, A. Sfeir, T. de Lange (2013) 53BP1 regulates DSB repair using Rif1 to control 5’ end resection. Science 6120: 700-704.

F. Lottersberger**, A. Bothmer**, D.F. Robbiani, M. Nussenzweig*, T. de Lange* (2013) Role of 53BP1 oligomerization in regulating DSB repair. Proc. Natl. Acad. Sci. USA, 110: 2146-2151. **equal contribution. *corresponding author.

F Lottersberger , A Panza, G Lucchini, MP Longhese (2007) Functional and physical interactions between yeast 14-3-3, acetyltransferase and deacetylase proteins in response to DNA replication stress. Mol Cell Biol 27: 3266-3281.

F Lottersberger , A Panza, S Piatti, G Lucchini, MP Longhese (2006) The Saccharomyces cerevisiae 14-3-3 Proteins Are Required for the G1/S Transition, Actin Cytoskeleton Organization and Cell Wall Integrity. Genetics 173 : 661-675.

M Clerici, V Baldo, D Mantiero, F Lottersberger , G Lucchini, MP Longhese (2004) A Tel1/MRX-dependent checkpoint inhibits the metaphase-to-anaphase transition after UV irradiation in the absence of Mec1. Mol Cell Biol 24: 10126-10144.

F Lottersberger , F Rubert, V Baldo, G Lucchini, and MP Longhese (2003) Functions of Saccharomyces cerevisiae 14-3-3 proteins in response to DNA damage and to DNA replication stress. Genetics 165 :1717-1732.


Courtney Lovejoy Publications:
C.A. Lovejoy, W. Li, S. Reisenweber, S. Thongthip, J. Bruno, T. de Lange*, S. De, J.H.J. Petrini, P.A. Sung, M. Jasin, J. Rosenbluh, Y. Zwang, B.A. Weir, C. Hatton, E. Ivanova, L. Macconaill, M. Hanna, W.C. Hahn, N.F. Lue, R.R. Reddel, Y. Jiao, K. Kinzler, B. Vogelstein, N. Papadopoulos, A.K. Meeker. For the ALT Starr Cancer Consortium. (2012) Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the Alternative Lengthening of Telomeres pathway. PLoS Genetics 8:e1002772 * corresponding author.

T Wiltshire, CA Lovejoy, T Wang, F Xia, MJ O'Connor, and D Cortez, (2010) Sensitivity to poly(ADP-ribose) polymerase (PARP) inhibition identifies ubiquitin-specific peptidase 11 (USP11) as a regulator of DNA double-strand break repair. J Biol Chem 285: 14565-14571

CA Lovejoy, X Xu, CE Bansbach, GG Glick, R Zhao, F Ye, BM Sirbu, LC Titus, Y Shyr, D Cortez (2009) Functional genomic screens identify CINP as a genome maintenance protein. Proc Nat Acad Sci 106: 19304-19309.

CE Bansbach, R B�tous, CA Lovejoy, GG Glick, D Cortez (2009) The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks. Genes Dev 23: 2405-2414.

CA Lovejoy, D Cortez (2009) Common mechanisms of PIKK regulation. DNA Repair (Amst) 8: 1004-1008.

CA Lovejoy, K Lock, A Yenamandra, D Cortez (2006) DDB1 maintains genome integrity through regulation of Cdt1. Mol Cell Biol 21: 7977-90.

AJ Danielsen, TA Christensen, CA Lovejoy, MA Adelsman, DC Connolly, NJ Maihle (2004) Membrane localization of v-ErbB is required but not sufficient for ligand-independent transformation. Exp Cell Res 2: 285-293.

JL Boerner, AJ Danielsen, CA Lovejoy, Z Wang, SC Juneja, JM Faupel-Badger, JR Darce, NJ Maihle (2003) Grb2 regulation of the actin-based cytoskeleton is required for ligand-independent EGF receptor-mediated oncogenesis. Oncogene 22: 6679-6689.



John Maciejowski's Publications:
V. Rodriguez-Bravo, J. Maciejowski, J. Corona, H.K. Buch, P. Collin, M.T. Kanemaki, J.V. Shah, and P.V. Jallepalli (2014). Nuclear pores protect genome integrity by assembling a premitotic and mad1-dependent anaphase inhibitor. Cell 156: 1017-1031.

Randall-Paschal C, Maciejowski J, Jallepalli PV. (2012) A stringent requirement for Plk1 T210 phosphorylation during K-fiber assembly and chromosome congression. Chromosoma 121: 565-572

Maciejowski J, George KA, Terret ME, Zhang C, Shokat KM, Jallepalli PV (2010)  Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling. J Cell Biol. 190: 89-100

McGovern M, Voutev R, Maciejowski J, Corsi AK, Hubbard EJ (2009) A “latent niche” mechanism for tumor initiation. Proc Natl Acad Sci USA. 106: 11617-22

Burkard ME, Maciejowski J, Rodriguez-Bravo V, Repka M, Lowery DM, Clauser KR, Zhang C, Shokat KM, Carr SA, Yaffe MB, Jallepalli PV (2009) Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells. PLoS Biol. 7: e10000111

Maciejowski J, Ugel N, Mishra B, Isopi M, Hubbard EJ (2006) Quantitative analysis of germline mitosis in adult C. elegans. Dev Biol. 292: 142-51

Maciejowski J, Ahn JH, Cipriani PG, Killian DJ, Chaudhary AL, Lee JI, Voutev R, Johnsen RC, Baillie DL, Gunsalus KC, Fitch DH, Hubbard EJ (2005) Autosomal genes of autosomal/X-linked duplicated gene pairs and germ-line proliferation in Caenorhabditis elegans. Genetics 169: 1997-2011

Isabelle Schmutz Publications:
I. Schmutz, J. A. Ripperger, S. Baeriswyl-Aebischer and U. Albrecht (2010): �The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors�. Genes Dev 24(4): 345-357.� PMCID: PMC2816734

F. Stadler, I. Schmutz, B. Schwaller, and U. Albrecht (2010): �Lack of calbindin-D28K alters response of the murine circadian clock to light�. Chronobiol. Int, 27(1): 68-82

M. Darna, I. Schmutz, K. Richter, S.V. Yelamanchili, G. Pendyala, M. H�ltje, U. Albrecht, G. Ahnert-Hilger (2009): �Time of Day-dependent Sorting of the Vesicular Glutamate Transporter to the Plasma Membrane�. J Biol Chem 284(7): 4300-4307

G. Hampp, J.A. Ripperger, T. Houben, I. Schmutz, C. Blex, S. Perreau-Lenz, I. Brunk, R. Spanagel, G. Ahnert-Hilger, J.H. Meijer, U. Albrecht (2008): �Regulation of monoamine oxidase A by circadian-clock components implies clock influence on mood.� Curr Biol 18(9): 678-683

MA Farr�-Castany, B Schwaller, P Gregory, J Barski, C Mariethoz, JL Eriksson, IV Tetko. D Wolfer, MR Celio, I Schmutz, U Albrecht, AE Villa (2007): �Differences in locomotor behavior revealed in mice deficient for the calcium-binding proteins parvalbulin, calbindin D-28k or both. Behav Brain Res 178 (2): 250-261

C Jud, I Schmutz, G Hampp, H Oster, U Albrecht (2005): �A guideline for analyzing circadian wheel-running behavior in rodents under different lighting conditions�. Biol Proced Online 7: 101-116


Hiro Takai Publications:

E.A. Ahmed, A. Sfeir, H. Takai, and H. Scherthan (2013). Ku70 and non-homologous end joining protect testicular cells from DNA damage. J Cell Sci 126: 3095-3104.

P. Wu, H. Takai and T. de Lange (2012) Telomeric 3' Overhangs Derive from Resection by Exo1 and Apollo and Fill-In by POT1b-Associated CST. Cell 150: 39-52.

Z. Horejsi, H. Takai, S. Collins, H. Flynn, S. Maslen, J.M. Skehel, T. de Lange, and S. Boulton (2010) CK2 phospho-dependent binding of R2TP complex to Tel2 is essential for mTOR and SMG1 stability. Mol. Cell, 39:839-850.

H. Takai, Y. Xiey*, T. de Lange** and N.P. Pavletich** (2010) Tel2 is a helical repeat protein that mediates Hsp90-dependent maturation of mTOR and ATR complexes. Genes Dev. 24: 2019-2030.

H. Takai, R. Wang, K. Takai, H. Yang, and T. de Lange (2007) Tel2 regulates the stability of PI3K-related protein kinases. Cell 131: 1248-1259.

D. Hockemeyer, J.-P. Daniels, H. Takai, and T. de Lange (2006) Recent expansion of the telomeric complex in rodents: two distinct POT1 proteins protect mouse telomeres. Cell 126: 63-77.

L Cao, S Kim, C Xiao, R Wang, X Coumoul, X Wang, WM Li, X XuL, JA De Soto, H Takai, S Mai, SJ Elledge, N Motoyama, CX Deng. (2006) ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency. EMBO J 25: 2167-77.

J. Silverman, H. Takai, S.B.C. Buonomo, F. Eisenhaber, and T. de Lange (2004) Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. Genes and Development 18: 2108-2119.

MT Jack, RA Woo, N Motoyama, H Takai, Lee PW. (2004) DNA-dependent protein kinase and checkpoint kinase 2 synergistically activate a latent population of p53 upon DNA damage. J Biol Chem 279: 15269-15273.

H. Takai, A. Smogorzewska, and T. de Lange (2003) DNA damage foci at dysfunctional telomeres. Curr. Biol. 13: 1549-1556.

J. Karlseder, L. Kachatrian, H. Takai, K. Mercer, S. Hingorani, T. Jacks, and T. de Lange (2003) Targeted deletion reveals an essential function for the telomere length regulator Trf1. Mol. Cell. Biol., 23: 6533-6541.

H Takai, K Naka, M Watanabe, Y Okada, H Sawa, M Nakanishi, H Suzuki, K Nagashima, K Ikeda, N Motoyama. (2002) Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription.  EMBO J  21: 5195-5205

K Kobayashi, M Watanabe, Y Okada, H Takai, H Sawa, M Nakanishi, H Suzuki, K Nagashima, K Ikeda, N Motoyama. (2002) Hydrocephalus and male infertility in DNA polymerase alpha-deficient mice. Mol Cell Biol 22: 2769-2776

T Sasaki, S Kamimura, H Takai, A Watanabe, K Onitake (2002) The activity for the induction of the sperm acrosome reaction localizes in the outer layers and exists in the high-molecular-weight components of the egg-jelly of the newt, Cynops pyrrhogaster. Zygote 10: 1-9

H Takai, K Tominaga, N Motoyama, YA Minamishima, H Nagahama, T Tsukiyama, K Ikeda, K Nakayama, M Nakanishi, K Nakayma K. (2000) Aberrant cell cycle checkpoint function and early embryonic death in Chk1-/- mice. Genes Dev 14: 1439-1447

M Kanematsu, T Sato, H Takai, K Watanabe, K Ikeda, Y Yamada. (2000) PGE2 induces expression of RANKL on pre-B cells: implications for accelerated osteoclastogenesis in estrogen deficiency.  J Bone Miner Res 15: 1321-1329

K Onitake, H Takai, M Ukita, JI Mizuno, T Sasaki, A Watanabe. (2000) Significance of egg-jelly substances in the internal fertilization of the newt, Cynops pyrrhogaster. Comp Biochem Physiol B Biochem Mol Biol 126: 121-128

H Mohri, K Inaba, M Kubo-Irie, H Takai, Y Yano-Toyoshima. (1999) Characterization of outer arm dynein in sea anemone, Anthopleira midori. Cell Motil Cytoskeleton 44: 202-208

H Takai, M Kanematsu, K Yano, E Tsuda, K Higashio, K Ikeda, K Watanabe, Y Yamada. (1998) TGF-β stimulates the production of Osteoprotegerin/Osteoclastogenesis Inhibitory Factor by bone marrow stromal cells.  J Biol Chem 273: 27091-27096

M Kanematsu, H Takai, Y Yamada. (1998) Actions of nitric oxide in the regulation of osteoclasts and osteoblasts. Curr Opinion Orthopedics 9: 11-16

Y Yamada, A Miyauti, J Goto, Y Takagi, H Okuizumi, M Kanematsu, M Hase, H Takai, A Harada, K Ikeda. (1998) Association of a polymorphism of the Transforming Growth Factor β-1 gene with genetic susceptibility to osteoporosis in postmenopausal Japanese women. J Bone Miner Res 13: 1569-1576

T Kameda, H Mano, Y Yamada, H Takai, N Amizuka, M Kobori, N Izumi, H Kawasima, H Ozawa, K Ikeda, A Kameda, Y Hakeda, M Kumegawa (1998) Calcium-sensing receptor in mature osteoclasts, which are bone resorbing cells.  Biochem Biophys Res Commun 245: 419-422.

K Ogawa, H Takai, A Ogiwara, E Yokota, T ShimizuT, K Inaba, H Mohri. (1996) Is outer arm dynein intermediate chain 1 multifunctional? Mol Biol Cell 7: 1895-1907

H Shimizu, T Majima, H Takai, K Inaba, T Tomie (1995) Morphological changes of wrasse sperm axoneme after their motility initiation observed with use of atomic force microscopy. SPIE 2384: 45-51.

H Takai and M Morisawa (1995) Change in intracellular K+ concentration caused by external osmolality change regulates sperm motility of marine and freshwater teleosts.  J Cell Sci 108: 1175-1181


Michal Zimmerman's Publications:
M. Zimmermann, F. Lottersberger, S. Buonomo, A. Sfeir, T. de Lange (2013) 53BP1 regulates DSB repair using Rif1 to control 5’ end resection. Science 6120: 700-704.

M. Zimmermann, and T. de Lange (2013). 53BP1: pro choice in DNA repair. Trends Cell Biol 24: 108-117.

F. Hobor, R. Pergoli, K. Kubicek, D. Hrossova, V. Bacikova, M. Zimmermann, J. Pasulka, C. Hofr, S. Vanacova, and R. Stefl (2011). Recognition of transcription termination signal by the nuclear polyadenylated RNA-binding (NAB) 3 protein. J Biol Chem 286: 3645-3657.

R. Stefl, F.C. Oberstrass, J.L. Hood, M. Jourdan, M. Zimmermann, L. Skrisovska, C. Maris, L. Peng, C. Hofr, R.B. Emeson, and F.H. Allain (2010). The solution structure of the ADAR2 dsRBM-RNA complex reveals a sequence-specific readout of the minor groove. Cell 143: 225-237.

M. Varecha, M. Zimmermann, J. Amrichova, V. Ulman, P. Matula, and M. Kozubek (2009). Prediction of localization and interactions of apoptotic proteins. J Biomed Sci 16: 59.

C. Hofr, P. Sultesova, M. Zimmermann, I. Mozgova, P. Prochazkova Schrumpfova, M. Wimmerova, and J. Fajkus (2009). Single-Myb-histone proteins from Arabidopsis thaliana: a quantitative study of telomere-binding specificity and kinetics. Biochem J 419: 221-8, 2 p following 228.

M. Varecha, J. Amrichova, M. Zimmermann, V. Ulman, E. Lukasova, and M. Kozubek (2007). Bioinformatic and image analyses of the cellular localization of the apoptotic proteins endonuclease G, AIF, and AMID during apoptosis in human cells. Apoptosis 12: 1155-1171.


Graduate Students

Shaheen Kabir Publications:
S. Kabir, A. Sfeir, and T. de Lange (2010) Taking apart Rap1: an adaptor protein with telomeric and non-telomeric functions. Cell Cycle 20: 4061-4067.

A. Sfeir, S. Kabir, M. van Overbeek, G.B. Celli, T. de Lange (2010) Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal. Science 327: 1657-1661.

BQ Vuong, M Lee, S Kabir, C Irimia, S Macchiarulo, GS McKnight, J Chaudhuri (2009) Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination. Nat Immunol 10: 420-426


Roos Anna Karssemeijer Publications:
S.K. Dougan, J. Ashour, R.A. Karssemeijer, M.W. Popp, A.M. Avalos, M. Barisa, A.F. Altenburg, J.R. Ingram, J.J. Cragnolini, C. Guo, F.W. Alt, R. Jaenisch, and H.L. Ploegh (2013). Antigen-specific B-cell receptor sensitizes B cells to infection by influenza virus. Nature ePub ahead of print

H.A. Schreiber, J. Loschko, R.A. Karssemeijer, A. Escolano, M.M. Meredith, D. Mucida, P. Guermonprez, and M.C. Nussenzweig (2013). Intestinal monocytes and macrophages are required for T cell polarization in response to Citrobacter rodentium. J. Exp. Med. 210: 2025-2039.

M.W. Popp, R.A. Karssemeijer, and H.L. Ploegh (2012). Chemoenzymatic site-specific labeling of influenza glycoproteins as a tool to observe virus budding in real time. PLoS Pathog. 8: e1002604.

J.S. Yount, R.A. Karssemeijer, and H.C. Hang (2012). S-palmitoylation and ubiquitination differentially regulate interferon-induced transmembrane protein 3 (IFITM3)-mediated resistance to influenza virus. J. Biol. Chem. 287: 19631-19641.

C.E. van der Poel, R.A. Karssemeijer, P. Boross, J.A. van der Linden, M. Blokland, J.G. van de Winkel, and J.H. Leusen (2010). Cytokine-induced immune complex binding to the high-affinity IgG receptor, FcgammaRI, in the presence of monomeric IgG. Blood 116: 5327-5333.



Research Assistants

Kaori Takai Publications:
K. Takai, T. Kibe, J. Donigian, D. Frescas and T. de Lange (2011) Telomere Protection by TPP1/POT1 Requires Tethering to TIN2. Mol. Cell, 44: 647-659.

K. Takai, S. Hooper, S. Blackwood, T. de Lange (2010) In Vivo stoichiometry of shelterin complex. J. Biol. Chem. 285: 1457-1467.

H. Takai, R. Wang, K. Takai, H. Yang, and T. de Lange (2007) Tel2 regulates the stability of PI3K-related protein kinases. Cell 131: 1248-1259.

D. Hockemeyer, W. Palm, T. Else, J.-P. Daniels, K. Takai, J. Z.-S. Ye, T. de Lange, and G. Hammer (2007) Telomere protection by mammalian POT1 requires interaction with TPP1. Nature Structural and Molecular Biology 8:754-61.

E Itakura, K Takai, K Umeda, M Kimura, M Ohsumi, K Tamai, and A Matsuura, (2004) Amino-terminal domain of ATRIP contributes to intranuclear relocation of the ATR-ATRIP complex following DNA damage. FEBS Lett 577: 289-293

C Kitazawa, K Takai, Y Nakajima, H Fujisawa, S Amemiya, (2004) LiCl inhibits the establishment of left-right asymmetry in larvae of the direct-developing echinoid Peronella japonica. J Exp Zool A Comp Exp Biol FEBS Lett Cell Struct Funct Hepatology 301: 707-17

K Takai, S Hattori, and S Irie, (2001) Type V collagen distribution in liver is reconstructed in coculture system of hepatocytes and stellate cells; the possible functions of type V collagen in liver under normal and pathological conditions. Cell Struct Funct 26: 289-302

C Tateno, K Takai-Kajihara, C Yamasaki, H Sato, and K Yoshizato, (2000) Heterogeneity of growth potential of adult rat hepatocytes in vitro. Hepatology 31: 65-74