Immunohistochemical study of Nova-1 expression. Nova is expressed exclusively in the central nervous system. Within the spinal cord, Nova-1 is expressed primarily in the ventral spinal cord (vsc; from (link to: Buckanovich RJ, Posner JB, Darnell RB Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system. Neuron. 1993;11:657-672 ); see also (link to following two articles: Buckanovich RJ, Darnell RB The neuronal RNA binding protein Nova-1 recognizes specific RNA targets in vitro and in vivo. MOL CELL BIOL 1997 JUN;17(6):3194-3201 and Yang YYL, Yin GL, Darnell RB The neuronal RNA-binding protein Nova-2 is implicated as the autoantigen targeted in POMA patients with dementia. PROC NAT ACAD SCI USA 1998 OCT;95(22):13254-13259).