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Overview: From hidden genes to new chemistry

The Laboratory of Genetically Encoded Small Molecules
The Rockefeller University and Howard Hughes Medical Institute

Desert Overview Photo
The lab's research interests center on both the discovery and the functional characterization of new small molecules from previously inaccessible genetic sources. We are particularly interested in the use of both functional and sequence-based strategies to access bioactive small molecules from both uncultured bacteria and the genomes of sequenced bacterial pathogens. Gaining functional access to previously inaccessible natural product biosynthetic pathways should significantly increase the number and diversity of natural products that are available for use in the development of small molecule therapeutics as well as provide a better understanding of how these metabolites are used by bacterial pathogens. Our research program is multidisciplinary, relying on techniques from the fields of molecular biology, analytic chemistry, microbiology and genomics. A background in any of these fields is welcome in the lab.

We are always looking for well-qualified postdocs and graduate students with backgrounds in microbiology, analytical chemistry, molecular biology, synthetic biology or bioinformatics and an interest in natural product chemistry. To apply for a postdoctoral position in the lab please send a CV and cover letter directly to Sean. The Rockefeller University has two graduate programs that may interest potential graduate students. We have a general graduate program ( and a chemical biology program ( both of which are dynamic world-class graduate programs.

Sean F. Brady
Howard Hughes Medical Institute
Tri-Institutional Associate Professor
Head, Laboratory of Genetically Encoded Small Molecules
The Rockefeller University
1230 York Avenue, Box 273
New York, NY 10065

Tel: 212 327-8280
Fax: 212 327-8281